Эволюция представлений о воспалительных заболеваниях кишечника у детей

История изучения воспалительных заболеваний кишечника (ВЗК, IBD) насчитывает не одно столетие. Одно из первых задокументированных описаний воспалительного заболевания кишечника датируется 1859 годом. С тех пор заболевания претерпели значительный патоморфоз. В представленном обзоре проанализированы современные данные о причинно-значимых факторах развития ВЗК. Патогенетические механизмы формирования воспалительных заболеваний кишечника и патоморфоз клинической картины. Особое внимание уделено анализу терапевтической тактики и эффективности противовоспалительной терапии с учетом возраста больного и степени тяжести заболевания. Материал и методы: для выполнения этих задач был произведен поиск результатов рандомизированных исследований, метанализов в современной отечественной и зарубежной литературе глубиной более 5лет. Заключение: согласно данным современной литературы, частота ВЗК неуклонно растет, как у взрослых, так и в детском возрасте. Наблюдается значительное омоложение заболевания. Среди приоритетных методов терапии при болезни Крона выделяют.., ЯК…

inflammatory bowel disease, IBD, IBDU, ulcerative colitis, Crohn’s disease, gut microbiota, biological therapy, children

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