Целиакия у взрослых практические рекомендации

Составлены специалистами НОГР на основании национальных рекомендаций по диагностике и лечению целиакии, рекомендаций по диагностике целиакии НОГР, Европейского общества детской гастроэнтерологии, гепатологии и питания (ESPGHAN), Общества детских гастроэнтерологов гепатологов и нутрициологов и данных литературы. Основанием для обновления и пересмотра рекомендаций послужили новые сведения исследований, опубликованных в последние годы в соответствие с научными данными в этой области. Рекомендации применимы в медицинской деятельности в рамках Порядка оказания медицинской помощи населению при заболеваниях гастроэнтерологического профиля. Настоящие рекомендации по диагностике и лечению больных целиакией являются руководством для практических врачей, осуществляющих диагностику целиакии, ведение и лечение таких пациентов.

целиакия, глютензависимые заболевания, тканевая трансглютаминаза

1. Rosenbaum J.T. Celiac Disease and Autoimmunity - The Missing Ingredient. N Engl J Med. 2017 Oct 12;377(15):1489-1490. doi: 10.1056/NEJMcibr1706917.

2. Al-Toma A., Volta U., Auricchio R. et al. European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United European Gastro-enterol J. 2019 Jun;7(5):583-613. doi: 10.1177/2050640619844125.

3. Husby S., Koletzko S., Korponay-Szabó I.R. et al; ESPGHAN Working Group on Coeliac Disease Diag-nosis; ESPGHAN Gastroenterology Committee; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr. 2012 Jan;54(1):136-60. doi: 10.1097/MPG.0b013e31821a23d0.

4. Szaflarska-Popławska A. The Role of the Gluten-Free Diet in the Management of Seronegative Enteropathy. Nutrients. 2021 Nov 11;13(11):4027. doi: 10.3390/nu13114027.

5. Glissen Brown J.R., Singh P. Coeliac disease. Paediatr Int Child Health. 2019 Feb;39(1):23-31. doi: 10.1080/20469047.2018.1504431.

6. Mazzola A.M., Zammarchi I., Valerii M.C., Spisni E., Saracino I.M., Lanzarotto F., Ricci C. Gluten-Free Diet and Other Celiac Disease Therapies: Current Understanding and Emerging Strategies. Nutrients. 2024 Mar 29;16(7):1006. doi: 10.3390/nu16071006.

7. Singh P., Arora A., Strand T.A. et al. Global Prevalence of Ce-liac Disease: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2018 Jun;16(6):823-836.e2. doi: 10.1016/j.cgh.2017.06.037.

8. van Gils T., Nijeboer P., IJssennagger C.E., Sanders D.S., Mulder C.J., Bouma G. Prevalence and Characterization of Self-Reported Gluten Sensitivity in The Netherlands. Nutrients. 2016 Nov 8;8(11):714. doi: 10.3390/nu8110714.

9. Potter M.D.E., Walker M.M., Jones M.P., Koloski N.A., Keely S., Talley N.J. Wheat Intolerance and Chronic Gastrointestinal Symptoms in an Australian Population-based Study: Association Between Wheat Sensitivity, Celiac Disease and Functional Gastrointestinal Disorders. Am J Gastroenterol. 2018 Jul;113(7):1036-1044. doi: 10.1038/s41395-018-0095-7.

10. Potter M., Jones M.P., Walker M.M., Koloski N.A., Keely S., Holtmann G., Talley Ac N.J. Incidence and prevalence of self-reported non-coeliac wheat sensitivity and gluten avoidance in Australia. Med J Aust. 2020 Feb;212(3):126-131. doi: 10.5694/mja2.50458.

11. Araya M., Bascuñán K.A., Alarcón-Sajarópulos D., Cabrera-Chávez F., Oyarzún A., Fernández A., Ontiveros N. Living with Glu-ten and Other Food Intolerances: Self-Reported Diagnoses and Management. Nutrients. 2020 Jun 26;12(6):1892. doi: 10.3390/nu12061892.

12. Ontiveros N., López-Gallardo J.A., Vergara-Jiménez M.J., Cabrera-Chávez F. Self-Reported Prevalence of Symptomatic Ad-verse Reactions to Gluten and Adherence to Gluten-Free Diet in an Adult Mexican Population. Nutrients. 2015 Jul 21;7(7):6000-15. doi: 10.3390/nu7075267.

13. Cabrera-Chávez F., Granda-Restrepo D.M., Arámburo-Gálvez J.G. et al. Self-Reported Prevalence of Gluten-Related Disorders and Adherence to Gluten-Free Diet in Colombian Adult Population. Gastroenterol Res Pract. 2016;2016:4704309. doi: 10.1155/2016/4704309.

14. Sciurti M., Fornaroli F., Gaiani F. et al. Genetic susceptibilty and celiac dis-ease: what role do HLA haplotypes play? Acta Biomed. 2018 Dec 17;89(9-S):17-21. doi: 10.23750/abm.v89i9-S.7953.

15. Espino L., Núñez C. The HLA complex and coeliac disease.Int Rev Cell Mol Biol. 2021;358:47-83. doi: 10.1016/bs.ircmb.2020.09.009.

16. Soderquist C.R., Bhagat G. Cellular and molecular bases of refractory celiac disease.Int Rev Cell Mol Biol. 2021;358:207-240. doi: 10.1016/bs.ircmb.2020.12.001.

17. Skoracka K., Hryhorowicz S., Tovoli F. et al. Genetic, Immunological, Dietary, Gut Microbiota, and Environmental Determinants of Osteoporosis in the Course of Celiac Disease: Which Factor Plays the First Violin in This Orchestra? Calcif Tissue Int. 2024 Feb;114(2):98-109. doi: 10.1007/s00223-023-01155-3.

18. Parfenov A.I. Celiac disease. Gee-Herter-Heubner disease. Moscow, MIA, 2023. (in Russ.)@@ Парфенов А.И. Целиакия. Болезнь Ги-Гертера-Гейбнера, Москва, МИА, 2023.

19. Lee L.W., Shafiani S., Crossley B. et al. Characterisation of T cell receptor repertoires in coeliac disease. J Clin Pathol. 2024 Jan 18;77(2):116-124. doi: 10.1136/jcp-2022-208541.

20. Ozuna C.V., Iehisa J.C., Giménez M.J., Alvarez J.B., Sousa C., Barro F. Diversification of the celiac disease α-gliadin complex in wheat: a 33-mer peptide with six overlapping epitopes, evolved following polyploidization. Plant J. 2015 Jun;82(5):794-805. doi: 10.1111/tpj.12851.

21. Dieli-Crimi R., Cénit M.C., Núñez C. The genetics of celiac disease: A comprehensive review of clinical implications. J Auto-immun. 2015 Nov;64:26-41. doi: 10.1016/j.jaut.2015.07.003.

22. Lebwohl B., Sanders D.S., Green P.H.R. Coeliac disease. Lancet. 2018 Jan 6;391(10115):70-81. doi: 10.1016/S0140-6736(17)31796-8.

23. Brophy K., Ryan A.W., Turner G. et al. Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study. BMC Med Genet. 2010 May 17;11:76. doi: 10.1186/1471-2350-11-76.

24. Wolters V.M., Wijmenga C. Genetic background of celiac disease and its clinical implications. Am J Gastroenterol. 2008 Jan;103(1):190-5. doi: 10.1111/j.1572-0241.2007.01471.x.

25. Vermeulen B.A., Hogen Esch C.E., Yuksel Z. et al. Phenotypic vari-ance in childhood coeliac disease and the HLA-DQ/DR dose effect. Scand J Gastroenterol. 2009;44(1):40-5. doi: 10.1080/00365520802116422.

26. Tye-Din J.A. Review article: Follow-up of coeliac disease. Aliment Pharmacol Ther. 2022 Jul;56 Suppl 1(Suppl 1): S49-S63. doi: 10.1111/apt.16847.

27. Fernández-Bañares F., Beltrán B., Salas A. et al; CADER study group. Per-sistent Villous Atrophy in De Novo Adult Patients With Celiac Disease and Strict Control of Gluten-Free Diet Adherence: A Multicenter Prospective Study (CADER Study). Am J Gastroenterol. 2021 May 1;116(5):1036-1043. doi: 10.14309/ajg.0000000000001139.

28. Jansson-Knodell C.L., Murray J.A., Rubio-Tapia A. Management of Small Bowel Villous Atrophy in Patients Seronegative for Celiac Disease. Am J Gastroenterol. 2020 Apr;115(4):492-497. doi: 10.14309/ajg.0000000000000575.

29. Sturgeon C., Lan J., Fasano A. Zonulin transgenic mice show altered gut permeability and increased morbidity/mortality in the DSS colitis model. Ann N Y Acad Sci. 2017 Jun;1397(1):130-142. doi: 10.1111/nyas.13343.

30. Pourmohammadi K., Abedi E, Hashemi S.M.B. Gliadin and glutenin genomes and their effects on the technological aspect of wheat-based products. Curr Res Food Sci. 2023 Oct 28;7:100622. doi: 10.1016/j.crfs.2023.100622.

31. Olivares M., Neef A., Castillejo G. et al. The HLA-DQ2 genotype selects for early intestinal microbiota composition in infants at high risk of developing coeliac disease. Gut. 2015 Mar;64(3):406-17. doi: 10.1136/gutjnl-2014-306931.

32. Sitkin S.I., Avalueva E.B., Oreshko L.S., Khavkin A.I.Intestinal microbiota and dysbiosis in celiac disease. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2021;66(2):116-122. (In Russ.) doi: 10.21508/1027-4065-2021-66-2-116-122.@@ Ситкин С.И., Авалуева Е.Б., Орешко Л.С., Хавкин А.И. Микробиота и дисбиоз кишечника при целиакии. Российский вестник перинатологии и педиатрии. 2021;66(2):116-122. doi: 10.21508/1027-4065-2021-66-2-116-122.

33. Sitkin S.I., Vakhitov T. Ya., Tkachenko E.I. et al. Gut microbial and endogenous metabolism alterations in ulcerative colitis and celiac disease: a metabolomics approach to identify candidate biomarkers of chronic intestinal inflammation associated with dysbiosis. Experimental and Clinical Gastroenterology. 2017;(7):4-50. (In Russ.)@@ Ситкин С.И., Вахитов Т.Я., Ткаченко Е.И. и др. Нарушения микробного и эндогенного метаболизма при язвенном колите и целиакии: метаболомный подход к выявлению потенциальных биомаркеров хронического воспаления в кишечнике, связанного с дисбиозом. Экспериментальная и клиническая гастроэнтерология. 2017;(7):4-50.

34. Balakireva A.V., Zamyatnin A.A. Properties of Gluten Intolerance: Gluten Structure, Evolution, Pathogenicity and Detoxifica-tion Capabilities. Nutrients. 2016 Oct 18;8(10):644. doi: 10.3390/nu8100644.

35. Leonard M.M., Karathia H., Pujolassos M. et al.; CD-GEMM Team. Multi-omics analysis reveals the influence of genetic and environmental risk factors on developing gut microbiota in infants at risk of celiac disease. Microbiome. 2020 Sep 11;8(1):130. doi: 10.1186/s40168-020-00906-w.

36. Bascuñán K.A., Araya M., Roncoroni L., Doneda L., Elli L. Dietary Gluten as a Conditioning Factor of the Gut Microbiota in Celiac Disease. Adv Nutr. 2020 Jan 1;11(1):160-174. doi: 10.1093/advances/nmz080.

37. Bakulin I.G., Avalueva E.B., Semenova E.A., Оrеshkо L.S., Serkova M. Yu., Sitkin S.I. Prospects for the treatment of gluten-associated diseases: on our daily bread, celiac disease, gluten proteins and more… Almanac of Clinical Medicine. 2022;50. (in Russ.) doi: 10.18786/2072-0505-2022-50-053.@@ Бакулин И.Г., Авалуева Е.Б., Семенова Е.А., Орешко Л.С., Серкова М.Ю., Ситкин С.И. Перспективы лечения глютен-ассоциированных заболеваний: о хлебе насущном, целиакии, белках глютена и не только… Альманах клинической медицины. 2022;50. doi: 10.18786/2072-0505-2022-50-053.

38. Simón E., Molero-Luis M., Fueyo-Díaz R., Costas-Batlle C., Crespo-Escobar P., Montoro-Huguet M.A. The Gluten-Free Diet for Celiac Disease: Critical Insights to Better Understand Clinical Outcomes. Nutrients. 2023 Sep 16;15(18):4013. doi: 10.3390/nu15184013.

39. Uche-Anya E., Lebwohl B. Celiac disease: clinical update. Curr Opin Gastroenterol. 2021 Nov 1;37(6):619-624. doi: 10.1097/MOG.0000000000000785.

40. Li D., Wang P., Wang P., Hu X., Chen F. The gut microbiota: A treasure for human health. Biotechnol Adv. 2016 Nov 15;34(7):1210-1224. doi: 10.1016/j.biotechadv.2016.08.003.

41. Sitkin S.I., Vakhitov T. Ya., Tkachenko E.I. et al. Dysbiosis in ulcerative colitis and celiac disease and its therapeutic correction by butyric acid plus inulin. Experimental and Clinical Gastroenterology. 2017;(6):77-98. (In Russ.)@@ Ситкин С.И., Вахитов Т.Я., Ткаченко Е.И. и др. Дисбиоз кишечника при язвенном колите и целиакии и его терапевтическая коррекция с помощью масляной кислоты в комбинации с инулином. Экспериментальная и клиническая гастроэнтерология. 2017;(6):77-98.

42. Banaganapalli B., Mansour H., Mohammed A. et al. Exploring celiac disease candidate pathways by global gene expression profiling and gene network clus-ter analysis. Sci Rep. 2020 Oct 1;10(1):16290. doi: 10.1038/s41598-020-73288-6.

43. Oreshko L.S., Bakulin I.G., Avalueva E.B., Semenova E.A., Sitkin S.I. Modern understanding of adult celiac disease. Exper-imental and Clinical Gastroenterology. 2021;(4):84-95. (In Russ.) doi: 10.31146/1682-8658-ecg-188-4-84-95.@@ Орешко Л.С., Бакулин И.Г., Авалуева Е.Б., Семенова Е.А., Ситкин С.И. Современное представление о целиакии взрослых. Экспериментальная и клиническая гастроэнтерология. 2021;(4):84-95. doi: 10.31146/1682-8658-ecg-188-4-84-95.

44. Oreshko L.S., Ledentsova S.S., Seliverstov P.V., Salikova S.P., Ivanyuk E.S. Pathophysiology of anemic syndrome in celiac disease and its therapeutic treatment. Medical alphabet. 2023;(28):13-18. (In Russ.) doi: 10.33667/2078-5631-2023-28-13-18.@@ Орешко Л.С., Леденцова С.С., Селиверстов П.В., Саликова С.П., Иванюк Е.С. Патофизиология анемического синдрома при целиакии и его терапевтическое лечение. Медицинский алфавит. 2023;(28):13-18. doi: 10.33667/2078-5631-2023-28-13-18.

45. Majsiak E., Cichoż-Lach H., Gubska O., Cukrowska B. Celiakia - choroba dzieci i dorosłych: objawy, powikłania, grupy ryzyka i choroby współistniejące [Celiac disease - disease of children and adults: symptoms, disease complications, risk groups and comorbidities]. Pol Merkur Lekarski. 2018 Jan 23;44(259):31-35. Polish. PMID: 29374421.

46. Leffler D.A., Schuppan D. Update on serologic testing in celiac disease. Am J Gastroenterol. 2010 Dec;105(12):2520-4. doi: 10.1038/ajg.2010.276.

47. Hadithi M., von Blomberg B.M., Crusius J.B. et al. Accuracy of serologic tests and HLA-DQ typing for diagnosing celiac disease. Ann Intern Med. 2007 Sep 4;147(5):294-302. doi: 10.7326/0003-4819-147-5-200709040-00003.

48. Schiepatti A., Sanders D.S., Zuffada M., Luinetti O., Iraqi A., Biagi F. Overview in the clinical management of patients with ser-onegative villous atrophy. Eur J Gastroenterol Hepatol. 2019 Apr;31(4):409-417. doi: 10.1097/MEG.0000000000001340.

49. Leonard M.M., Lebwohl B., Rubio-Tapia A., Biagi F. AGA Clinical Practice Update on the Evaluation and Management of Seronegative Enteropathies: Expert Review. Gastroenterology. 2021 Jan;160(1):437-444. doi: 10.1053/j.gastro.2020.08.061.

50. Hujoel I.A., Jansson-Knodell C.L., Hujoel P.P., Hujoel M.L.A., Choung R.S., Murray JA., Rubio-Tapia A. Estimating the Impact of Verification Bias on Celiac Disease Testing. J Clin Gastroenterol. 2021 Apr 1;55(4):327-334. doi: 10.1097/MCG.0000000000001361.

51. Arguelles-Grande C., Brar P., Green P.H., Bhagat G. Immunohistochemical and T-cell receptor gene rearrangement analyses as predictors of morbidity and mortality in refractory celiac disease. J Clin Gastroenterol. 2013 Aug;47(7):593-601. doi: 10.1097/MCG.0b013e31828a3c44.

52. Malamut G., Cellier C. Refractory Celiac Disease. Gastroenterol Clin North Am. 2019 Mar;48(1):137-144. doi: 10.1016/j.gtc.2018.09.010.

53. Ilus T., Kaukinen K., Virta L.J. et al. Refractory coeliac disease in a country with a high prevalence of clinically-diagnosed coeliac disease. Aliment Pharmacol Ther. 2014 Feb;39(4):418-25. doi: 10.1111/apt.12606.

54. Branchi F., Wiese J.J., Heldt C. et al. The combination of clinical parameters and immunophenotyping of intraepithelial lymphocytes allows to assess disease severity in refractory celiac disease. Dig Liver Dis. 2022 Dec;54(12):1649-1656. doi: 10.1016/j.dld.2022.06.024.

55. Zanini B., Marullo M., Villanacci V. et al. Persistent Intraepithelial Lymphocytosis in Celiac Patients Adhering to Gluten-Free Diet Is Not Abolished Despite a Gluten Contamination Elimination Diet. Nutrients. 2016 Aug 26;8(9):525. doi: 10.3390/nu8090525.

56. Cheminant M., Bruneau J., Malamut G. et al.; CELAC network°. NKp46 is a diagnostic biomarker and may be a therapeutic target in gastrointestinal T-cell lymphoproliferative diseases: a CELAC study. Gut. 2019 Aug;68(8):1396-1405. doi: 10.1136/gutjnl-2018-317371.

57. Farstad I.N., Johansen F.E., Vlatkovic L. et al. Heterogeneity of intraepithelial lymphocytes in refractory sprue: potential implications of CD30 expression. Gut. 2002 Sep;51(3):372-8. doi: 10.1136/gut.51.3.372.

58. Eigner W., Bashir K., Primas C. et al. Dynamics of occurrence of refractory coeliac disease and associated complications over 25 years. Aliment Pharmacol Ther. 2017 Jan;45(2):364-372. doi: 10.1111/apt.13867.

59. van Gils T., Nijeboer P., van Wanrooij R.L., Bouma G., Mulder C.J. Mechanisms and management of refractory coeliac disease. Nat Rev Gastroenterol Hepatol. 2015 Oct;12(10):572-9. doi: 10.1038/nrgastro.2015.155.

60. Gillett H.R., Arnott I.D., McIntyre M. et al. Successful infliximab treatment for steroid-refractory celiac disease: a case report. Gastroenterology. 2002 Mar;122(3):800-5. doi: 10.1053/gast.2002.31874.

61. Al-Toma A., Goerres M.S., Meijer J.W. et al. Cladribine therapy in refractory celiac disease with aberrant T cells. Clin Gastroenterol Hepatol. 2006 Nov;4(11):1322-7; quiz 1300. doi: 10.1016/j.cgh.2006.07.007.

62. Pelizzaro F., Marsilio I., Fassan M. et al. The Risk of Ma-lignancies in Celiac Disease-A Literature Review. Cancers (Basel). 2021 Oct 21;13(21):5288. doi: 10.3390/cancers13215288.

63. Kalra N., Mukherjee A., Sinha S., Muralidhar V., Serin Y., Tiwari A., Verma A.K. Current data on the association between celiac disease and cancer and on the effect of a gluten-free diet on risk change (review) Int. J. Function.Interior. 2022;3:2. doi: 10.3892/ijfn.2022.25.;

64. Packova B., Kohout P., Dastych M., Prokesova J., Grolich T., Kroupa R. Malignant complications of celiac disease: a case series and review of the literature. J Med Case Rep. 2022 Dec 12;16(1):460. doi: 10.1186/s13256-022-03682-3.

65. Han Y., Chen W., Li P., Ye J. Association Between Coeliac Disease and Risk of Any Malignancy and Gastrointestinal Malig-nancy: A Meta-Analysis. Medicine (Baltimore). 2015 Sep;94(38): e1612. doi: 10.1097/MD.0000000000001612.

66. Rampertab S.D., Forde K.A., Green P.H. Small bowel neoplasia in coeliac disease. Gut. 2003 Aug;52(8):1211-4. doi: 10.1136/gut.52.8.1211.

67. Emilsson L., Semrad C., Lebwohl B., Green P.H.R., Ludvigsson J.F. Risk of Small Bowel Adenocarcinoma, Adenomas, and Car-cinoids in a Nationwide Cohort of Individuals With Celiac Disease. Gastroenterology. 2020 Nov;159(5):1686-1694.e2. doi: 10.1053/j.gastro.2020.07.007.

68. Caio G., Volta U., Ursini F., Manfredini R., De Giorgio R. Small bowel adenocarcinoma as a complication of celiac disease: clinical and diagnostic features. BMC Gastroenterol. 2019 Mar 27;19(1):45. doi: 10.1186/s12876-019-0964-6.

69. Rizzo F., Vanoli A., Sahnane N. et al. Small-bowel carcinomas associated with celiac disease: transcriptomic profiling shows predominance of microsatellite instability-immune and mesenchymal subtypes. Vir-chows Arch. 2020 May;476(5):711-723. doi: 10.1007/s00428-019-02675-w.

70. Lasa J., Rausch A., Bracho L.F. et al. Colorectal Adenoma Risk Is In-creased among Recently Diagnosed Adult Celiac Disease Patients. Gastroenterol Res Pract. 2018 Apr 23;2018:6150145. doi: 10.1155/2018/6150145.

71. Krums L.M., Sabelnikova E.A. Diagnostics and treatment of chronic diseases of the small intestine. Moscow, 2020. 125 P. (in Russ.)@@ Крумс Л.М., Сабельникова Е.А. Диагностика и лечение хронических болезней тонкой кишки. Москва, 2020. С. 125.

72. van der Windt D.A., Jellema P., Mulder C.J., Kneepkens C.M., van der Horst H.E. Diagnostic testing for celiac disease among patients with abdominal symptoms: a systematic review. JAMA. 2010 May 5;303(17):1738-46. doi: 10.1001/jama.2010.549.

73. Plewa M.C., Chatterjee K. Recurrent Aphthous Stomatitis. 2023 Nov 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. PMID: 28613713.

74. Parfenov A.I. [New horizons of gluten sensitivity studies]. Ter Arkh. 2013;85(2):4-7.Russian. PMID: 23653930.

75. Parfenov A.I. Celiac disease. Evolution of ideas on prevalence, clinical manifestations and significance of etiotropic therapy / A.I. Parfenov. Moscow. Anakharis, 2007. 376 P. (in Russ.)

76. Murray J.A., Watson T., Clearman B., Mitros F. Effect of a gluten-free diet on gastrointestinal symptoms in celiac disease. Am J Clin Nutr. 2004 Apr;79(4):669-73. doi: 10.1093/ajcn/79.4.669.

77. Lazebnik L.B., Tkachenko Y.I., Oreshko L.S. et al; Scientific Society of Gastroentorology of Russia. [Guidelines for diagnosis and treatment of celiac disease]. Eksp Klin Gastroenterol. 2015;(5):3-12. (in Russ.) PMID: 26387169.@@ Лазебник Л.Б., Ткаченко Е.И., Орешко Л.С. и др. Рекомендации по диагностике и лечению целиакии взрослых. Экспериментальная и клиническая гастроэнтерология. 2015;(5):3-12.

78. Lucchese A., Di Stasio D., De Stefano S., Nardone M., Carinci F. Beyond the Gut: A Systematic Review of Oral Manifestations in Celiac Disease. J Clin Med. 2023 Jun 6;12(12):3874. doi: 10.3390/jcm12123874.

79. Wieser H., Ciacci C., Gizzi C., Santonicola A. Otorhinolaryngological Manifestations and Esophageal Disorders in Celiac Dis-ease: A Narrative Review. J Clin Med. 2023 Nov 10;12(22):7036. doi: 10.3390/jcm12227036.

80. Vajro P., Paolella G., Maggiore G., Giordano G. Pediatric celiac disease, cryptogenic hypertransaminasemia, and autoimmune hepatitis. J Pediatr Gastroenterol Nutr. 2013 Jun;56(6):663-70. doi: 10.1097/MPG.0b013e31828dc5c5.

81. Barbaro M.R., Cremon C., Wrona D. et al. Non-Celiac Gluten Sensitivity in the Context of Functional Gastrointestinal Disorders. Nutrients. 2020 Dec 4;12(12):3735. doi: 10.3390/nu12123735.

82. Yoosuf S., Singh P., Khaitan A., Strand T.A., Ahuja V., Makharia G.K. Prevalence of Celiac Disease in Patients With Liver Dis-eases: A Systematic Review and Meta-Analyses. Am J Gastroenterol. 2023 May 1;118(5):820-832. doi: 10.14309/ajg.0000000000002123.

83. Vignoli A., Orlandini B., Tenori L. et al. Metabolic Signature of Primary Biliary Cholangitis and Its Comparison with Celiac Disease. J Proteome Res. 2019 Mar 1;18(3):1228-1236. doi: 10.1021/acs.jproteome.8b00849.

84. Wieser H., Ciacci C., Soldaini C., Gizzi C., Santonicola A. Gastrointestinal and Hepatobiliary Manifestations Associated with Untreated Celiac Disease in Adults and Children: A Narrative Overview. J Clin Med. 2024 Aug 5;13(15):4579. doi: 10.3390/jcm13154579.

85. Romeo M., Nardo F.D., Napolitano C., Vaia P., Federico A., Dallio M. Primary biliary cholangitis, Celiac Disease, and MASLD: the triumvirate of steatosis. How should we manage this triple overlap? Dig Liver Dis. 2025 Feb;57(2):651-652. doi: 10.1016/j.dld.2024.11.007.

86. Scapaticci S., Venanzi A., Chiarelli F., Giannini C. MAFLD and Celiac Disease in Children.Int J Mol Sci. 2023 Jan 16;24(2):1764. doi: 10.3390/ijms24021764.

87. Wieser H., Chiacchi K., Soldaini K., Gizzi K., Santonikala A. Gastrointestinal and hepatobili-ary manifestations associated with untreated celiac disease in adults and children: a review article. J Clin Med. 2024. August 5; 13(15): 4579. doi: 10.3390/jcm13154579.

88. Wang H.H., Liu M., Li X., Portincasa P., Wang D.Q. Impaired intestinal cholecystokinin secretion, a fascinating but overlooked link between coeliac disease and cholesterol gallstone disease. Eur J Clin Invest. 2017 Apr;47(4):328-333. doi: 10.1111/eci.12734.

89. Hoffmanová I., Sánchez D., Tučková L., Tlaskalová-Hogenová H. Celiac Disease and Liver Disorders: From Putative Patho-genesis to Clinical Implications. Nutrients. 2018 Jul 12;10(7):892. doi: 10.3390/nu10070892.

90. Das S., Lal S.B., Venkatesh V. et al. Gallbladder motility in children with celiac disease before and after gluten-free diet. Ann Gastroenterol. 2021;34(3):385-391. doi: 10.20524/aog.2021.0593.

91. Poddighe D., Dossybayeva K., Abdukhakimova D., Akhmaltdinova L., Ibrayeva A. Celiac Disease and Gallbladder: Pathophys-iological Aspects and Clinical Issues. Nutrients. 2022 Oct 19;14(20):4379. doi: 10.3390/nu14204379.

92. Voss J., Schneider C.V., Kleinjans M., Bruns T., Trautwein C., Strnad P. Hepatobiliary phenotype of individuals with chronic in-testinal disorders. Sci Rep. 2021 Oct 7;11(1):19954. doi: 10.1038/s41598-021-98843-7.

93. Pezzilli R. Exocrine pancreas involvement in celiac disease: a review. Recent Pat Inflamm Allergy Drug Discov. 2014;8(3):167-72. doi: 10.2174/1872213x08666141122210738.

94. Alkhayyat M., Saleh M.A., Abureesh M. et al. The Risk of Acute and Chronic Pancreatitis in Celiac Disease. Dig Dis Sci. 2021 Aug;66(8):2691-2699. doi: 10.1007/s10620-020-06546-2.;

95. Balaban D.V., Enache I., Ciochina M., Popp A., Jinga M. Pancreatic involvement in celiac disease. World J Gastroenterol. 2022 Jun 28;28(24):2680-2688. doi: 10.3748/wjg.v28.i24.2680.;

96. Jiang C., Barkin J.A., Barkin J.S. Exocrine Pancreatic Insufficiency Is Common in Celiac Disease: A Systematic Review and Meta-Analysis. Dig Dis Sci. 2023 Aug;68(8):3421-3427. doi: 10.1007/s10620-023-07965-7.

97. Dev K., Rahul F., Makheja K. et al. Frequency of Cutaneous Disorders in Patients With Celiac Disease. Cureus. 2021 Sep 21;13(9): e18148. doi: 10.7759/cureus.18148.

98. Rodrigo L., Beteta-Gorriti V., Alvarez N. et al. Cutaneous and Mucosal Manifestations Associated with Celiac Disease. Nutrients. 2018 Jun 21;10(7):800. doi: 10.3390/nu10070800.

99. Lu C.Y., Hsieh M.S., Wei K.C., Ezmerli M., Kuo C.H., Chen W. Gastrointestinal involvement of primary skin diseases. J Eur Acad Dermatol Venereol. 2020 Dec;34(12):2766-2774. doi: 10.1111/jdv.16676.

100. García C., Araya M. Dermatitis herpetiforme y enfermedad celíaca. Del intestino a la piel [Dermatitis herpetiformis and celiac disease]. Rev Med Chil. 2021 Sep;149(9):1330-1338. Spanish. doi: 10.4067/S0034-98872021000901330.

101. Real-Delor R.E., Aldama-Negrete G., Aldama-Caballero A., Nunes-Tenace D., Aldama-Negrete F., Centurión-Medina I. Silent celiac disease in dermatology. Rev Med Inst Mex Seguro Soc. 2020;58(4):437-443. English. doi: 10.24875/RMIMSS.M20000068.

102. Shahriari M., Honar N., Yousefi A., Javaherizadeh H. Association of potential celiac disease and refractory iron deficiency anemia in children and adolescents. Arq Gastroenterol. 2018 Jan-Mar;55(1):78-81. doi: 10.1590/S0004-2803.201800000-15.

103. Scricciolo A., Elli L., Doneda L. et al. Efficacy of a High-Iron Dietary Intervention in Women with Celiac Disease and Iron Deficiency without Anemia: A Clinical Trial. Nutrients. 2020 Jul 17;12(7):2122. doi: 10.3390/nu12072122.

104. Talarico V., Giancotti L., Mazza G.A., Miniero R., Bertini M. Iron Deficiency Anemia in Celiac Disease. Nutrients. 2021 May 17;13(5):1695. doi: 10.3390/nu13051695.

105. Ben-Ami T., Trotskovsky A., Topf-Olivestone C., Kori M. Iron deficiency without anemia in children with newly diagnosed celiac disease: 1-year follow-up of ferritin levels, with and without iron supplementation. Eur J Pediatr. 2024 Nov;183(11):4705-4710. doi: 10.1007/s00431-024-05721-1.

106. Wu Y.C., Wu Y.H., Wang Y.P., Chang J.Y., Chen H.M., Sun A. Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis. J Formos Med Assoc. 2016 Dec;115(12):1061-1068. doi: 10.1016/j.jfma.2016.10.007.

107. Wiebolt J., Achterbergh R., den Boer A. et al. Clustering of additional autoimmunity behaves differently in Hashimoto’s patients compared with Graves’ patients. Eur J Endocrinol. 2011 May;164(5):789-94. doi: 10.1530/EJE-10-1172.

108. Starchl C., Scherkl M., Amrein K. Celiac Disease and the Thyroid: Highlighting the Roles of Vitamin D and Iron. Nutrients. 2021 May 21;13(6):1755. doi: 10.3390/nu13061755.

109. Ashok T., Patni N., Fatima M., Lamis A., Siddiqui S.W. Celiac Disease and Autoimmune Thyroid Disease: The Two Peas in a Pod. Cureus. 2022 Jun 23;14(6): e26243. doi: 10.7759/cureus.26243.

110. Piticchio T., Frasca F., Malandrino P. et al. Effect of gluten-free di-et on autoimmune thyroiditis progression in patients with no symptoms or histology of celiac disease: a meta-analysis. Front Endocrinol (Lausanne). 2023 Jul 24;14:1200372. doi: 10.3389/fendo.2023.1200372.

111. Rubio-Tapia A., Hill I.D., Semrad C. et al. American College of Gastroenterology Guidelines Update: Diagnosis and Management of Celiac Disease. Am J Gastroenterol. 2023 Jan 1;118(1):59-76. doi: 10.14309/ajg.0000000000002075.

112. Ray S., Gillett P.M., Le Huray V., Bremner G., Paul S.P. Updated European guidelines for coeliac disease in children. Nurs Child Young People. 2023 Jul 6;35(4):16-21. doi: 10.7748/ncyp.2022.e1452.

113. Di Stefano M., Miceli E., Mengoli C., Corazza G.R., Di Sabatino A. The Effect of a Gluten-Free Diet on Vitamin D Metabolism in Celiac Disease: The State of the Art. Metabolites. 2023 Jan 2;13(1):74. doi: 10.3390/metabo13010074.

114. Kondapalli A.V., Walker M.D. Celiac disease and bone. Arch Endocrinol Metab. 2022 Nov 11;66(5):756-764. doi: 10.20945/2359-3997000000561.

115. Ramírez Stieben L.A., Pustilnik E., Néstor Rodolfo F., Bolzán D., Bedini I. Celiac disease and primary hyperparathyroidism. Rev Fac Cien Med Univ Nac Cordoba. 2023 Dec 26;80(4):499-509. doi: 10.31053/1853.0605.v80.n4.42137.

116. Oreshko L.S., Semenova E.A., Alieva G. Ch., Basyul O.V. Reproductive changes in women with celiac disease. Experimental and Clinical Gastroenterology. 2021;(4):144-149. (In Russ.) doi: 10.31146/1682-8658-ecg-188-4-150-154.@@ Орешко Л.С., Семенова Е.А., Алиева Г.Ч., Басюл О.В. Репродуктивные изменения у женщин с целиакией. Экспериментальная и клиническая гастроэнтерология. 2021;(4):144-149. doi: 10.31146/1682-8658-ecg-188-4-150-154.

117. Glimberg I., Haggård L., Lebwohl B., Green P.H.R., Ludvigsson J.F. The prevalence of celiac disease in women with infertility-A systematic review with meta-analysis. Reprod Med Biol. 2021 Mar 22;20(2):224-233. doi: 10.1002/rmb2.12374.

118. Alecsandru D., López-Palacios N., Castaño M., Aparicio P., García-Velasco J.A., Núñez C. Exploring undiagnosed celiac disease in women with recurrent reproductive failure: The gluten-free diet could improve reproductive outcomes. Am J Reprod Im-munol. 2020 Feb;83(2): e13209. doi: 10.1111/aji.13209.

119. Arvanitakis K., Siargkas A., Germanidis G., Dagklis T., Tsakiridis I. Adverse pregnancy outcomes in women with celiac dis-ease: a systematic review and meta-analysis. Ann Gastroenterol. 2023 Jan-Feb;36(1):12-24. doi: 10.20524/aog.2022.0764.

120. Mearns E.S., Taylor A., Thomas Craig K.J. et al. Neurological Manifestations of Neuropathy and Ataxia in Celiac Disease: A Systematic Review. Nutrients. 2019 Feb 12;11(2):380. doi: 10.3390/nu11020380.

121. Fanaeian M.M., Alibeik N., Ganji A., Fakheri H., Ekhlasi G., Shahbazkhani B. Prevalence of migraine in adults with celiac dis-ease: A case control cross-sectional study. PLoS One. 2021 Nov 17;16(11): e0259502. doi: 10.1371/journal.pone.0259502.

122. Gala D., Scharf S., Kudlak M. et al. A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment. Diseases. 2022 Nov 21;10(4):111. doi: 10.3390/diseases10040111.

123. Casciato S., Morano A., Albini M. et al. Cryptogenic focal epilepsy and “hidden” celiac disease in adulthood: a causal or accidental link? Int J Neuro-sci. 2015;125(12):913-7. doi: 10.3109/00207454.2014.983227.

124. Trovato C.M., Raucci U., Valitutti F. et al. Neuropsychiatric manifestations in celiac disease. Epilepsy Behav. 2019 Oct;99:106393. doi: 10.1016/j.yebeh.2019.06.036.

125. Patel S.C., Shreya D., Zamora D.I. et al. Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations. Cureus. 2021 Dec 2;13(12): e20112. doi: 10.7759/cureus.20112.

126. Clappison E., Hadjivassiliou M., Zis P. Psychiatric Manifestations of Coeliac Disease, a Systematic Review and Meta-Analysis. Nutrients. 2020 Jan 4;12(1):142. doi: 10.3390/nu12010142.

127. Barberis N., Quattropani M.C., Cuzzocrea F. Relationship between motivation, adherence to diet, anxiety symptoms, depression symptoms and quality of life in individuals with celiac disease. J Psychosom Res. 2019 Sep;124:109787. doi: 10.1016/j.jpsychores.2019.109787.

128. Sainsbury K., Mullan B., Sharpe L. Reduced quality of life in coeliac disease is more strongly associated with depression than gastrointestinal symptoms. J Psychosom Res. 2013 Aug;75(2):135-41. doi: 10.1016/j.jpsychores.2013.05.011.

129. Alkhayyat M., Qapaja T., Aggarwal M. et al. Epi-demiology and risk of psychiatric disorders among patients with celiac disease: A population-based national study. J Gastro-enterol Hepatol. 2021 Aug;36(8):2165-2170. doi: 10.1111/jgh.15437.

130. Skjellerudsveen B.M., Omdal R., Grimstad T. Fatigue in celiac disease: A review of the literature. JGH Open. 2019 Jan 8;3(3):242-248. doi: 10.1002/jgh3.12134.

131. Germone M., Phu T., Slosky C. et al. Anxiety and Depression in Pediatric Patients with Celiac Disease: A Large Cross-Sectional Study. J Pediatr Gastroenterol Nutr. 2022 Aug 1;75(2):181-185. doi: 10.1097/MPG.0000000000003497.

132. Alkhiari R. Psychiatric and Neurological Manifestations of Celiac Disease in Adults. Cureus. 2023 Mar 3;15(3): e35712. doi: 10.7759/cureus.35712.

133. Catassi C., Verdu E.F., Bai J.C., Lionetti E. Coeliac disease. Lancet. 2022 Jun 25;399(10344):2413-2426. doi: 10.1016/S0140-6736(22)00794-2.

134. Owens S.R., Greenson J.K. The pathology of malabsorption: current concepts. Histopathology. 2007 Jan;50(1):64-82. doi: 10.1111/j.1365-2559.2006.02547.x.

135. Ballestero-Fernández C., Varela-Moreiras G., Úbeda N., Alonso-Aperte E. Nutritional Status in Spanish Adults with Celiac Disease Following a Long-Term Gluten-Free Diet Is Similar to Non-Celiac. Nutrients. 2021 May 12;13(5):1626. doi: 10.3390/nu13051626.

136. Ciacci C., Bilancio G., Russo I. et al. Zingone F. 25-Hydroxyvitamin D, 1,25-Dihydroxyvitamin D, and Peripheral Bone Densitometry in Adults with Celiac Disease. Nutrients. 2020 Mar 27;12(4):929. doi: 10.3390/nu12040929.

137. Tavakkoli A., DiGiacomo D., Green P.H., Lebwohl B. Vitamin D status and concomitant autoimmunity in celiac disease. J Clin Gastroenterol. 2013 Jul;47(6):515-9. doi: 10.1097/MCG.0b013e318266f81b.

138. Dima A., Jurcut C., Manolache A., Balaban D.V., Popp A., Jinga M. Hemorrhagic Events in Adult Celiac Disease Patients. Case Report and Review of the Literature. J Gastrointestin Liver Dis. 2018 Mar;27(1):93-99. doi: 10.15403/jgld.2014.1121.271.cld.

139. Soylu A., Öztürk Y., Doğan Y., Özmen D., Yılmaz Ö., Kuyum P., Kavukçu S. Screening of celiac disease in children with Henoch-Schoenlein purpura. Rheumatol Int. 2016 May;36(5):713-7. doi: 10.1007/s00296-016-3425-3.

140. Poddighe D., Romano M., Dossybayeva K., Abdukhakimova D., Galiyeva D., Demirkaya E. Celiac Disease in Juvenile Idio-pathic Arthritis and Other Pediatric Rheumatic Disorders. J Clin Med. 2022 Feb 18;11(4):1089. doi: 10.3390/jcm11041089.

141. Beas R., Altamirano-Farfan E., Izquierdo-Veraza D. et al. Prevalence of celiac disease in systemic lupus erythematosus, sjogren syndrome and systemic sclerosis: A systematic review and meta-analysis. Dig Liver Dis. 2024 Sep;56(9):1475-1482. doi: 10.1016/j.dld.2024.03.015.

142. Rubio-Tapia A., Hill I.D., Kelly C.P., Calderwood A.H., Murray J.A.; American College of Gastroenterology. ACG clinical guide-lines: diagnosis and management of celiac disease. Am J Gastroenterol. 2013 May;108(5):656-76; quiz 677. doi: 10.1038/ajg.2013.79.

143. Documents and orders: Celiac disease. Global practical recommendations of the World Gastroenterology Organization (WGO) 2016. (in Russ.) Available at: https://endoexpert.ru/dokumenty-i-prikazy/tseliakiya-globalnye-prakticheskie-rekomendatsii-vsemirnoy-gastroenterologicheskoy-organizatsii-vgo-/(Accessed: 01.02.2025).@@ Документы и приказы: Целиакия. Глобальные практические рекомендации Всемирной Гастроэнтерологической Организации ВГО (WGO) 2016. https://endoexpert.ru/dokumenty-i-prikazy/tseliakiya-globalnye-prakticheskie-rekomendatsii-vsemirnoy-gastroenterologicheskoy-organizatsii-vgo-/

144. Husby S., Koletzko S., Korponay-Szabó I. et al. European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020. J Pediatr Gastroenterol Nutr. 2020 Jan;70(1):141-156. doi: 10.1097/MPG.0000000000002497.

145. Examination of patients diagnosed with celiac disease Russian guidelines for follow-up care for patients diagnosed with celiac disease. (in Russ.) Available at: https://autoimmun.ru/guide/zabolevaniya-zhkt/obsledovanie-patsientov-s-ustanovlennym-diagnozom-tseliakiya/https://676.su/G2it (Accessed 05.01/2-25).

146. Hoerter N.A., Shannahan S.E., Suarez J., Lewis S.K., Green P.H.R., Leffler D.A., Lebwohl B. Diagnostic Yield of Isolated Deamidated Gliadin Peptide Antibody Elevation for Celiac Disease. Dig Dis Sci. 2017 May;62(5):1272-1276. doi: 10.1007/s10620-017-4474-5.

147. Hoerter N.A., Shannahan S.E., Suarez J. et al. Diagnostic Yield of Isolated Deamidated Gliadin Peptide Antibody Elevation for Celiac Disease. Dig Dis Sci. 2017 May;62(5):1272-1276. doi: 10.1007/s10620-017-4474-5.

148. Hujoel I.A., Jansson-Knodell C.L., Hujoel P.P. et al. Estimating the Impact of Verification Bias on Celiac Disease Testing. J Clin Gastroenterol. 2021 Apr 1;55(4):327-334. doi: 10.1097/MCG.0000000000001361.

149. Magazzù G., Aquilina S., Barbara C. et al. Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project-Global Strategy Protocol. Pediatr Rep. 2022 Jun 10;14(2):293-311. doi: 10.3390/pediatric14020037.

150. Singh P., Arora A., Strand T.A. et al. Diagnostic Accuracy of Point of Care Tests for Diagnosing Celiac Disease: A Systematic Review and Meta-Analysis. J Clin Gastroenterol. 2019 Aug;53(7):535-542. doi: 10.1097/MCG.0000000000001081.

151. Shiha M.G., Nandi N., Oka P. et al. Narrow-band imaging for optical diagnosis of duodenal villous atrophy in patients with suspected coeliac disease: A systematic review and meta-analysis. Dig Liver Dis. 2024 Jun;56(6):971-977. doi: 10.1016/j.dld.2023.08.053.

152. Latorre M., Lagana S.M., Freedberg D.E., Lewis S.K., Lebwohl B., Bhagat G., Green P.H. Endoscopic biopsy technique in the di-agnosis of celiac disease: one bite or two? Gastrointest Endosc. 2015 May;81(5):1228-33. doi: 10.1016/j.gie.2014.10.024.

153. Elli L., Leffler D., Cellier C. et al. Guidelines for best practices in monitoring established coeliac disease in adult patients. Nat Rev Gastroenterol Hepatol. 2024 Mar;21(3):198-215. doi: 10.1038/s41575-023-00872-2.

154. Fang H., King K.S., Larson J.J. et al. Undetectable negative tissue transglutaminase IgA antibodies predict mucosal healing in treated coeliac disease patients. Aliment Pharmacol Ther. 2017 Oct;46(7):681-687. doi: 10.1111/apt.14250.

155. Shiha M.G., Yusuf A., Sanders D.S. Role of endoscopy in the diagnosis of coeliac disease: a narrative review. Transl Gastroen-terol Hepatol. 2024 May 9;9:51. doi: 10.21037/tgh-23-122.

156. McCarty T.R., O’Brien C.R., Gremida A., Ling C., Rustagi T. Efficacy of duodenal bulb biopsy for diagnosis of celiac disease: a systematic review and meta-analysis. Endosc Int Open. 2018 Nov;6(11): E1369-E1378. doi: 10.1055/a-0732-5060.

157. Özakıncı H., Kırmızı A., Tural M., Kiremitçi S., Savaş B., Kuloğlu Z., Kansu A., Ensari A. Duodenal bulb biopsy in the diagnos-tic work-up of coeliac disease. Virchows Arch. 2020 Oct;477(4):507-515. doi: 10.1007/s00428-020-02832-6.

158. Parfenov A.I., Maev I.V., Baranov A.A. et al. The Russian consensus on diagnosis and treatment of coeliac disease in chil-dren and adults. Almanac of Clinical Medicine. 2016;44(6):661-668. (in Russ.) doi: 10.18786/2072-0505-2016-44-6-661-688.@@ Парфенов А.И., Маев И.В., Баранов А.А. и др. Всероссийский консенсус по диагностике и лечению целиакии у детей и взрослых (Принят на 42-й научной сессии Центрального научно-исследовательского института гастроэнтерологии; Москва, 2-3 марта 2016 г.). Альманах клинической медицины. 2016;44(6):661-668. doi:10.18786/2072-0505-2016-44-6-661-688.

159. Rettally C.A., Roy M. Biopsias duodenales: ¿toma de muestra individual o de muestras múltiples? [Duodenal Biopsies: Indi-vidual or Multiple Samples?]. Acta Gastroenterol Latinoam. 2022 Sep 29;52(3):385-387. Spanish. doi: 10.52787/agl.v52i3.213.

160. Rettally C. Duodenal Biopsies: Individual or Multiple Samples? Am J Gastroenterol. 2023 May 1;118(5):911-912. doi: 10.14309/ajg.0000000000002229.

161. Scheppach M.W., Rauber D., Stallhofer J. et al. Detection of duodenal villous atrophy on endoscopic images using a deep learning algorithm. Gastrointest Endosc. 2023 May;97(5):911-916. doi: 10.1016/j.gie.2023.01.006.

162. Villanacci V., Del Sordo R., Casella G., Becheanu G., Oberti A., Belfekih B., Bassotti G., Ravelli A. The correct methodological approach to the diagnosis of celiac disease: the point of view of the pathologist. Gastroenterol Hepatol Bed Bench. 2023;16(2):129-135. doi: 10.22037/ghfbb.v16i2.2704.

163. Marsh M.N. Mucosal pathology in gluten sensitivity / M.N. Marsh // Coeliac disease / ed. M.N. Marsh. - Oxford: Blackwell Scientific, 1992. pp. 136-191.

164. Oberhuber G., Granditsch G., Vogelsang H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol. 1999 Oct;11(10):1185-94. doi: 10.1097/00042737-199910000-00019.

165. Shiha M.G., Nandi N., Hutchinson A.J. et al. Cost-benefits and environmental impact of the no-biopsy approach for the diagnosis of coeliac disease in adults. Frontline Gastroenterol. 2023 Oct 3;15(2):95-98. doi: 10.1136/flgastro-2023-102494.

166. Packova B., Kovalcikova P., Pavlovsky Z. et al. Non-invasive prediction of persistent villous atrophy in celiac disease. World J Gastroenterol. 2020 Jul 14;26(26):3780-3791. doi: 10.3748/wjg.v26.i26.3780.

167. Dmitrieva Yu., Kasatkina E., Roslaytseva E. et al.Distribution of HLA-DR-DQ genotypes in Russian chil-dren with cocliac discase. J Pediatr Gastroenteral Nutr. 2018, April 66(S2):151.

168. Pinto-Sánchez M.I., Causada-Calo N., Bercik P. et al. Safety of Adding Oats to a Gluten-Free Diet for Patients With Celiac Disease: Sys-tematic Review and Meta-analysis of Clinical and Observational Studies. Gastroenterology. 2017 Aug;153(2):395-409.e3. doi: 10.1053/j.gastro.2017.04.009.

169. Dmitrieva Y.A., Roslavtseva E.A., Kuryaninova V.A. et al. Structure of the HLA-DR-DQ-genotype in children with coeliac disease. Meditsinskiy sovet = Medical Council. 2020;(10):74-80. (In Russ.) doi: 10.21518/2079-701X-2020-10-74-80.@@ Дмитриева Ю.А., Рославцева Е.А., Курьянинова В.А. и др. Структура HLA-DR-DQ-генотипа у детей с целиакией. Медицинский Совет. 2020;(10):74-80. doi: 10.21518/2079-701X-2020-10-74-80.

170. Parfenov A.I., Bykova S.V., Sabel’nikova E.A. et al. All-Russian Consensus on Diagnosis and Treatment of Celiac Disease in Children and Adults. Therapeutic Archive. 2017;89(3):94-107. (In Russ.) doi: 10.17116/terarkh201789394-107.@@ Парфенов А.И., Быкова С.В., Сабельникова Е.А. и др. Всероссийский консенсус по диагностике и лечению целиакии у детей и взрослых. Терапевтический архив. 2017;89(3):94-107. doi: 10.17116/terarkh201789394-107.

171. Sainsbury K., Mullan B., Sharpe L. A randomized controlled trial of an online intervention to improve gluten-free diet adher-ence in celiac disease. Am J Gastroenterol. 2013 May;108(5):811-7. doi: 10.1038/ajg.2013.47.

172. Dewar D.H., Donnelly S.C., McLaughlin S.D. et al. Celiac disease: management of persistent symptoms in patients on a gluten-free diet. World J Gastroenterol. 2012;18:1348-56.

173. Rubio-Tapia A., Murray J.A. Classification and management of refractory coeliac disease. Gut. 2010 Apr;59(4):547-57. doi: 10.1136/gut.2009.195131.

174. Barret M., Malamut G., Rahmi G. et al. Diagnostic yield of capsule endoscopy in refractory celiac disease. Am J Gastroenterol. 2012 Oct;107(10):1546-53. doi: 10.1038/ajg.2012.199.

175. Hujoel I.A., Murray J.A. Refractory Celiac Disease. Curr Gastroenterol Rep. 2020 Mar 17;22(4):18. doi: 10.1007/s11894-020-0756-8.

176. Malamut G., Soderquist C.R., Bhagat G., Cerf-Bensussan N. Advances in Nonresponsive and Refractory Celiac Disease. Gastroenterology. 2024 Jun;167(1):132-147. doi: 10.1053/j.gastro.2024.02.048.

177. Welstead L. The Gluten-Free Diet in the 3rd Millennium: Rules, Risks and Opportunities. Diseases. 2015 Jul 13;3(3):136-149. doi: 10.3390/diseases3030136.

178. Taetzsch A., Das S.K., Brown C., Krauss A., Silver R.E., Roberts S.B. Are Gluten-Free Diets More Nutritious? An Evaluation of Self-Selected and Recommended Gluten-Free and Gluten-Containing Dietary Patterns. Nutrients. 2018 Dec 3;10(12):1881. doi: 10.3390/nu10121881.

179. Bascuñán K.A., Vespa M.C., Araya M. Celiac disease: understanding the gluten-free diet. Eur J Nutr. 2017 Mar;56(2):449-459. doi: 10.1007/s00394-016-1238-5.

180. Akhmadullina O.V., Sabelnikova E.A., Belostotsky N.I. et al. Enzymatic activity of the small intestinal mucosa in patients with celiac disease following a gluten-free diet. Doctor.Ru. 2017;2 (131):22-25. (in Russ.)@@ Ахмадуллина О.В., Сабельникова Е.А., Белостоцкий Н.И. и др. Ферментативная активность слизистой оболочки тонкой кишки у больных целиакией, соблюдающих аглютеновую диету // Доктор.Ру. 2017;2 (131):22-25.

181. Di Nardo G., Villa M.P., Conti L. et al. Nutritional Deficiencies in Children with Celiac Disease Resulting from a Gluten-Free Diet: A Systematic Review. Nutrients. 2019 Jul 13;11(7):1588. doi: 10.3390/nu11071588.

182. Aljada B., Zohni A., El-Matary W. The Gluten-Free Diet for Celiac Disease and Beyond. Nutrients. 2021 Nov 9;13(11):3993. doi: 10.3390/nu13113993.

183. Stanciu D., Staykov H., Dragomanova S., Tancheva L., Pop R.S., Ielciu I., Crișan G. Gluten Unraveled: Latest Insights on Termi-nology, Diagnosis, Pathophysiology, Dietary Strategies, and Intestinal Microbiota Modulations-A Decade in Review. Nutri-ents. 2024 Oct 25;16(21):3636. doi: 10.3390/nu16213636.

184. Roszkowska A., Pawlicka M., Mroczek A., Bałabuszek K., Nieradko-Iwanicka B. Non-Celiac Gluten Sensitivity: A Review. Medicina (Kaunas). 2019 May 28;55(6):222. doi: 10.3390/medicina55060222.

185. Khabutia M. Sh., Popova T.S., Saltanova A.I. Parenteral and enteral nutrition/ National guidelines. Moscow. GEOTAR-Media, 2014. 800 p. (in Russ.)@@ Хабутия М.Ш., Поповой Т.С., Салтанова А.И. Парентеральное и энтеральное питание/ Национальное руководство. - М.: ГЭОТАР-Медиа, 2014. - 800 с;

186. Luft V.M. Guide to clinical nutrition. St. Petersburg: Art-Express. 2016. 491 p. (in Russ.)@@ Руководство по клиническому питанию/под ред Луфта В.М. // СПб: Арт-Экспресс. 2016. - 491 с;

187. Petrikov S.S., Khabutia M. Sh., Popova T.S. [Parenteral and enteral nutrition]. National guidelines. Gzotar Media. 2023. 168 p. (in Russ.)@@ Парентеральное и энтеральное питание/ Национальное руководство под редакцией Петриков С.С., Хабутия М.Ш., Попова Т.С. Гзотар Медиа. 2023. 168 С.

188. Мinushkin О.N. New drugs (enzymes and probiotics) in clinical practice. Meditsinskiy sovet = Medical Council. 2022;(15):98-103. (In Russ.) doi: 10.21518/2079-701X-2022-16-15-98-103.@@ Минушкин О.Н. Новые препараты (ферменты и пробиотики) в клинической практике. Медицинский Совет. 2022;(15):98-103. doi: 10.21518/2079-701X-2022-16-15-98-103.

189. Yahav S., Berkovich Z., Ostrov I., Reifen R., Shemesh M. Encapsulation of beneficial probiotic bacteria in extracellular matrix from biofilm-forming Bacillus subtilis. Artif Cells Nanomed Biotechnol. 2018;46(sup2):974-982. doi: 10.1080/21691401.2018.1476373.

190. Freedman K.E., Hill J.L., Wei Y. et al. Examining the Gastrointestinal and Immunomodulatory Effects of the Novel Probiotic Bacillus subtilis DE111.Int J Mol Sci. 2021 Feb 28;22(5):2453. doi: 10.3390/ijms22052453.

191. Sitkin S.I., Vakhitov T. Ya., Tkachenko E.I. et al. Gut microbiota in ulcerative colitis and celiac disease. Experimental and Clinical Gastroenterology. 2017;(1):8-30. (In Russ.)@@ Ситкин С.И., Вахитов Т.Я., Ткаченко Е.И. и др. Микробиота кишечника при язвенном колите и целиакии. Экспериментальная и клиническая гастроэнтерология. 2017;(1):8-30.;

192. Hallert C., Svensson M., Tholstrup J., Hultberg B. Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet. Aliment Pharmacol Ther. 2009 Apr 15;29(8):811-6. doi: 10.1111/j.1365-2036.2009.03945.x.

193. Oreshko L.S., Kantemirova R.K., Salikova S.P., Oreshko A.Yu., Sinitsa A.V., Sinitsa A.A. Effectiveness and safety of a combination of Bacillus subtilis metabiotic, a complex of microbial and plant enzymes, and a prebiotic in patients with celiac disease on a long-term gluten-free diet. Experimental and Clinical Gastroenterology. 2025;(3):278-287. (In Russ.) doi: 10.31146/1682-8658-ecg-235-3-278-287.@@ Орешко Л.С., Кантемирова Р.К., Саликова С.П., Орешко А.Ю., Синица А.В., Синица А.А. Эффективность и безопасность применения комбинации метабиотика Bacillus subtilis, комплекса микробных и растительных ферментов и пребиотика у пациентов с целиакией на длительной безглютеновой диете. Экспериментальная и клиническая гастроэнтерология. 2025;(3):278-287. doi: 10.31146/1682-8658-ecg-235-3-278-287.

194. Green P.H.R., Paski S., Ko C.W., Rubio-Tapia A. AGA Clinical Practice Update on Management of Refractory Celiac Disease: Expert Review. Gastroenterology. 2022 Nov;163(5):1461-1469. doi: 10.1053/j.gastro.2022.07.086.

195. Expósito Miranda M., García-Valdés L., Espigares-Rodríguez E., Leno-Durán E., Requena P. Non-celiac gluten sensitivity: Clinical presentation, etiology and differential diagnosis. Gastroenterol Hepatol. 2023 Aug-Sep;46(7):562-571. English, Spanish. doi: 10.1016/j.gastrohep.2022.10.001.

196. Zingone F., Bertin L., Maniero D. et al. Myths and Facts about Food Intol-erance: A Narrative Review. Nutrients. 2023 Nov 30;15(23):4969. doi: 10.3390/nu15234969.

197. Lu Y., Ji H., Chen Y., Li Z., Timira V. A systematic review on the recent advances of wheat allergen detection by mass spec-trometry: future prospects. Crit Rev Food Sci Nutr. 2023 Nov;63(33):12324-12340. doi: 10.1080/10408398.2022.2101091.

198. Pasta A., Formisano E., Calabrese F. et al. Food Intol-erances, Food Allergies and IBS: Lights and Shadows. Nutrients. 2024 Jan 16;16(2):265. doi: 10.3390/nu16020265.

199. Ricci G., Andreozzi L., Cipriani F., Giannetti A., Gallucci M., Caffarelli C. Wheat Allergy in Children: A Comprehensive Up-date. Medicina (Kaunas). 2019 Jul 23;55(7):400. doi: 10.3390/medicina55070400.

200. Anvari S., Miller J., Yeh C.Y., Davis C.M. IgE-Mediated Food Allergy. Clin Rev Allergy Immunol. 2019 Oct;57(2):244-260. doi: 10.1007/s12016-018-8710-3.

201. Taraghikhah N., Ashtari S., Asri N. et al. An updated overview of spectrum of gluten-related disorders: clinical and diagnostic aspects. BMC Gastroenterol. 2020 Aug 6;20(1):258. doi: 10.1186/s12876-020-01390-0.