The place of statins in the treatment of chronic periodontitis in patients with atherosclerosis of the coronary arteries

Abstract

The purpose of this work was to study the pleiotropic and lipid-lowering effects of statins in patients with chronic ischemic heart disease on the background of moderate periodontitis. Materials and methods: 80 patients with moderate periodontitis on the background of chronic coronary heart disease (HIBS) were examined. The first group included 40 patients with HIBS who underwent a thorough examination and were prescribed basic therapy using double antiplatelet therapy, rosuvastatin at a dose of 10 mg was prescribed on a regular basis, as well as rosuvastatin at a dose of 10 mg in the form of gum applications for 15 minutes for two weeks, then every other day for 3 months. The second group included 40 patients with diagnosed atherosclerosis - corresponding changes on the ECG or after coronary angiography. The following results were obtained: After 6 months of monitoring the indicators of the first and second groups, the differences in them changed even more in favor of the first group, whose patients received rosuvastatin at a dose of 10 mg orally and 10 mg in the form of gum applications under strict control. Almost all blood counts and changes in periodontal tissue once again confirm a decrease in the level of inflammation around the periodontium, a decrease in the level of plaque, the bleeding index, and the depth of the periodontal pocket. The analysis of the obtained data confirms the connection between atherosclerosis of the coronary arteries and chronic periodontitis. Against the background of taking statins, the level of OH, LDL decreases, and the level of HDL increases. Monitoring the intake of statins in elderly patients with moderate periodontitis with its use in the form of applications significantly reduces the level of C-reactive protein, which once again proves the pleiotropic effect of statins in the elderly against the background of chronic periodontitis.