Preview

Экспериментальная и клиническая гастроэнтерология

Расширенный поиск

СОВРЕМЕННЫЕ ВЗГЛЯДЫ НА МЕХАНИЗМЫ ФОРМИРОВАНИЯ И ПЕРСПЕКТИВЫ КУПИРОВАНИЯ БОЛЕВОГО АБДОМИНАЛЬНОГО СИНДРОМА У ПАЦИЕНТОВ ХРОНИЧЕСКИМ ПАНКРЕАТИТОМ

Полный текст:

Аннотация

Болевой абдоминальный синдром при хроническом панкреатите является одной из самых загадочных и сложных проблем современной гастроэнтерологии. В обзорной статье представлены современные сведения о внутрипанкреатических и центральных механизмах формирования болевого синдрома у пациентов с хроническим панкреатитом. На основании патогенетических механизмов намечены перспективы терапии пациентов хроническим панкреатитом с болевым синдромом.

Об авторах

В. А. Ахмедов
ГБОУ ВПО Омский государственный медицинский университет МЗ РФ
Россия


О. В. Гаус
ГБОУ ВПО Омский государственный медицинский университет МЗ РФ
Россия


Список литературы

1. Shrikhande S. V., Martignoni M. E., Shrikhande M. et al. Comparison of histological features and inflammatory cell reaction in alcoholic, idiopathic and tropical chronic pancreatitis // Br. J. Surg. 2003. - № 90. Р. 1565-1572.

2. Goecke H., Forssmann U., Uguccioni M. et al. Macrophages infiltrating the tissue in chronic pancreatitis express the chemokine receptor CCR5 // Surgery. 2000. - № 128. - Р. 806-814.

3. Nilius B., Owsianik G., Voets T., Peters J. A. Transient receptor potential cation channels in disease // Physiol Rev. 2007. - № 87. - Р. 165-217.

4. Vergnolle N., Cenac N., Altier C. et al. A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation // Br. J. Pharmacol. 2010. - 159. - Р. 1161-1173.

5. Hwang S. W., Cho H., Kwak J. et al. Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances // Proc. Natl. Acad. Sci. USA. - 2000. -№ 97. - Р. 6155-6160.

6. Geppetti P., Bertrand C., Ricciardolo F. L., Nadel J. A. New aspects on the role of kinins in neurogenic inflammation // Can. J. Physiol. Pharmacol. - 1995. - № 73. - Р. 843-847.

7. Xu G. Y., Winston J. H., Shenoy M. et al. Transient receptor potential vanilloid 1 mediates hyperalgesia and is up-regulated in rats with chronic pancreatitis // Gastroenterology. - 2007. - № 133. - Р.1282-1292.

8. Hartel M., di Mola F. F., Selvaggi F et al. Vanilloids in pancreatic cancer: potential for chemotherapy and pain management // Gut. - 2006. - № 55. - Р. 519-528.

9. Ceppa E., Cattaruzza F., Lyo V. et al. Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice // Am. J. Physiol. Gastrointest. Liver. Physiol. - 2010. - № 299. - G 556-G 571.

10. Jordt S. E., Bautista D. M., Chuang H. H. et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1 // Nature. 2004. - № 427. - Р. 260-265.

11. Bautista D. M., Jordt S. E., Nikai T. et al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents // Cell. - 2006. - № 124. - Р. 1269-1282.

12. McNamara C.R., Mandel-Brehm J., Bautista D. M. et al. TRPA1 mediates formalin-induced pain // Proc. Natl. Acad. Sci. USA. - 2007. - № 104. - Р. 13525-13530.

13. Cattaruzza F., Johnson C., Leggit A. Et al. Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice // Am. J. Physiol. Gastrointest. Liver. Physiol. - 2013. - № 304. - G1002-G1012.

14. Pedersen S., Lambert I. H., Thoroed S. M. et al. Hypotonic cell swelling induces translocation of the alpha isoform of cytosolic phospholipase A2 but not the gamma isoform in Ehrlich ascites tumor cells. Eur J Biochem. - 2000. - № 267. - Р. 5531-5539.

15. Schwartz E. S., La J. H., Scheff N. N. et al. TRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitis. J Neurosci. - 2013. - № 33. - P. 5603-5611.

16. Hoogerwerf W. A., Zou L., Shenoy M. et al. The proteinase activated receptor 2 is involved in nociception. J. Neurosci. - 2001. - № 21. - Р. 9036-9042.

17. Hoogerwerf W. A., Gondesen K., Xiao S. Y. et al. The role of mast cells in the pathogenesis of pain in chronic pancreatitis. BMC Gastroenterol. - 2005. - № 5. - Р. 8.

18. Kawabata A., Matsunami M., Tsutsumi M. et al. Suppression of pancreatitis-related allodynia/hyperalgesia by proteinase activated receptor-2 in mice. Br. J. Pharmacol. - 2006. - № 148. - P. 54-60.

19. Toma H., Winston J., Micci M. A. et al. Nerve growth factor expression is up-regulated in the rat model of L-arginine-induced acute pancreatitis. Gastroenterology. - 2000. - № 119. - Р. 1373-1381.

20. Djouhri L., Dawbarn D., Robertson A. et al. Time course and nerve growth factor dependence of inflammation induced alterations in electrophysiological membrane properties in nociceptive primary afferent neurons. J. Neurosci - 2001. - № 21. - Р. 8722-8733.

21. Ceyhan G. O., Bergmann F., Kadihasanoglu M. et al. The neurotrophic factor artemin influences the extent of neural damage and growth in chronic pancreatitis. Gut. 2007. - № 56. - Р. 534-544.

22. Hughes M. S., Shenoy M., Liu L. Et al. Brain-derived neurotrophic factor is upregulated in rats with chronic pancreatitis and mediates pain behavior. Pancreas. 2011. - № 40. - Р. 551-556.

23. Bouwense SA, de Vries M, Schreuder LT. Systematic mechanism-orientated approach to chronic pancreatitis pain. World. J Gastroenterol. - 2015. - № 21. - Р. 47-59.

24. Vardanyan M., Melemedjian O. K., Price T. J. et al. Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain. - 2010. - № 151. - Р. 257-265.

25. Di Sebastiano P., di Mola F. F., Di Febbo C. Et al. Expression of interleukin 8 (IL-8) and substance P in human chronic pancreatitis. Gut. - 2000. - № 47. - Р. 423-428.

26. Ceyhan G. O., Deucker S., Demir I. E. et al. Neural fractalkine expression is closely linked to pain and pancreatic neuritis in human chronic pancreatitis. Lab. Invest. - 2009. - № 89. - Р. 347-361.

27. Michalski C. W., Shi X., Reiser C. Et al. Neurokinin-2 receptor levels correlate with intensity, frequency, and duration of pain in chronic pancreatitis. Ann Surg. - 2007. - № 246. - Р. 786-793.

28. Winston J. H., He Z. J., Shenoy M. et al. Molecular and behavioral changes in nociception in a novel rat model of chronic pancreatitis for the study of pain. Pain. - 2005. - № 117. - Р. 214-222.

29. Friess H., Shrikhande S., Shrikhande M. et al. Neural alterations in surgical stage chronic pancreatitis are independent of the underlying aetiology. Gut. - 2002. - № 50. - Р. 682-686.

30. Ceyhan G. O., Bergmann F., Kadihasanoglu M. et al. Pancreatic neuropathy and neuropathic pain- a comprehensive pathomorphological study of 546 cases. Gastroenterology. - 2009. - № 136. - Р. 177-186.

31. Di Sebastiano P., Fink T., Weihe E. Et al. Immune cell infiltration and growth-associated protein 43 expression correlate with pain in chronic pancreatitis. Gastroenterology. - 1997. - № 112. - Р. 1648-1655.

32. Dimcevski G., Sami S. A., Funch-Jensen P. et al. Pain in chronic pancreatitis: the role of reorganization in the central nervous system. Gastroenterology. - 2007. - № 132. - Р. 1546-1556.

33. Olesen S. S., Frøkjær JB, Lelic D. et al. Pain associated adaptive cortical reorganisation in chronic pancreatitis. Pancreatology. - 2010. - № 10. - Р. 742-751.

34. de Vries M., Wilder-Smith O.H., Jongsma M. L. et al. Altered resting state EEG in chronic pancreatitis patients: toward a marker for chronic pain. J. Pain. Res. - 2013. - № 6. - Р. 815-824.

35. Frøkjær JB., Olesen S. S., Graversen C. et al. Neuroimaging of the human visceral pain system - a methodological review. Scand. J. Pain. - 2011. - № 2. - Р. 95-104.

36. Frøkjær J. B., Bouwense S. A., Olesen S. S. et al. Reduced cortical thickness of brain areas involved in pain processing in patients with chronic pancreatitis. Clin Gastroenterol Hepatol. - 2012. - № 10. - Р. 434-438.

37. Frøkjær J. B., Andersen L. W., Brock C. et al. Altered brain microstructure assessed by diffusion tensor imaging in patients with diabetes and gastrointestinal symptoms. Diabetes Care. - 2013. - № 36. - Р. 662-668.

38. Zhu Y., Mehta K., Li C. Et al. Systemic administration of anti-NGF increases A-type potassium currents and decreases pancreatic nociceptor excitability in a rat model of chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. - 2012. - № 302 -: G176-G181.

39. Pasricha P. J. Unraveling the mystery of pain in chronic pancreatitis. Nat Rev Gastroenterol Hepatol. 2012. - № 9. - Р. 140-151.

40. Xu C., Shen J., Zhang J. et al. Recombinant interleukin-1 receptor antagonist attenuates the severity of chronic pancreatitis induced by TNBS in rats. Biochem Pharmacol. - 2015. - № 93. - Р. 449-460.

41. Bouwense S. A., Buscher H. C., van Goor H. Et al. S-ketamine modulates hyperalgesia in patients with chronic pancreatitis pain. Reg Anesth Pain Med. - 2011. - № 36. - Р. 303-307.

42. Ilkjaer S., Dirks J., Brennum J. et al. Effect of systemic N-methyl-D-aspartate receptor antagonist (dextromethorphan) on primary and secondary hyperalgesia in humans. Br J Anaesth. - 1997. - № 79. - Р. 600-605.

43. Olesen S. S., Bouwense S. A., Wilder-Smith O.H. et al. Pregabalin reduces pain in patients with chronic pancreatitis in a randomized, controlled trial. Gastroenterology. - 2011. - Vol. 141, № 2. - Р. 536-543.

44. Bouwense S. A., Olesen S. S., Drewes A. M. et al. Effects of pregabalin on central sensitization in patients with chronic pancreatitis in a randomized, controlled trial. PloS One. - 2012. - 7(8). - e42096.

45. Olesen S. S., van Goor H., Bouwense S. A. et al. Reliability of static and dynamic quantitative sensory testing in patients with painful chronic pancreatitis. Reg Anesth Pain Med. - 2012. - Vol. 37, № 5. - Р. 530-536.


Для цитирования:


Ахмедов В.А., Гаус О.В. СОВРЕМЕННЫЕ ВЗГЛЯДЫ НА МЕХАНИЗМЫ ФОРМИРОВАНИЯ И ПЕРСПЕКТИВЫ КУПИРОВАНИЯ БОЛЕВОГО АБДОМИНАЛЬНОГО СИНДРОМА У ПАЦИЕНТОВ ХРОНИЧЕСКИМ ПАНКРЕАТИТОМ. Экспериментальная и клиническая гастроэнтерология. 2016;(10):99-103.

For citation:


Akhmedov V.A., Gaus O.V. MODERN VIEWS ON THE MECHANISMS OF FORMATION AND PROSPECTS OF THERAPY OF THE PAIN ABDOMINAL SYNDROME IN PATIENTS WITH CHRONIC PANCREATITIS. Experimental and Clinical Gastroenterology. 2016;(10):99-103. (In Russ.)

Просмотров: 36


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 1682-8658 (Print)