COMPARATIVE RESEARCH OF EFFI CACY OF MONOTHERAPY WITH UDCA AND THE COMBINATION OF UDCA GIMEKROMONOM C IN PATIENTS WITH BILIARY SLUDGE2 STAGES

Abstract

Aim of research: Evaluate clinical advantages of combined therapy using Ursodeoxycholic acid (UDCA) with spasmolytic of patients with second stage biliary sludge (BS) - in a form of echo-heterogeneous bile containing clots. Materials and methods: 42 patients with 2nd stage BS were examined. 1st group (21 patients) was treated by UDCA monotherapy, 2nd group (21 patients) received combined therapy: UDCA with Hymecromone for 4 weeks. 4 week later, clinical and echographical assessment of the therapy provided was conducted. Results: patients who received the combined therapy had more expressed decrease of pain syndrome in the right hypochondrium than those who received the monotherapy. During the study of gallbladder contraction function (GCF) any reliable evidence of its change wasn’t found in both groups, thus the combined therapy (UDCA + Hymecromone) does not increase GCF. According to ultrasonography, an improvement of gallbladder content (transition from the 2nd stage BS to the 1st and reduction of an amount and size of clots and suspension) was observed in 81% patients from the 1st group (UDCA), and in 95% patients from the 2nd group (UDCA + Hymecromone). Conclusion: research data show increased effectiveness of treatment of patients with 2nd stage BS while using the combination of UDCA and Hymecromone.