Preview

Experimental and Clinical Gastroenterology

Advanced search

Differential diagnostic value of serum leptin level and polymorphism of the leptin receptor gene Gln223Arg in metabolic fatty and alcoholic liver diseases

https://doi.org/10.31146/1682-8658-ecg-230-10-155-161

Abstract

The aim of the investigation is the study of the serum leptin content and polymorphism of the leptin receptor gene glutamine 223 arginine (LEPRGln223Arg) as additional criteria for the differential diagnosis of metabolic and alcoholic liver diseases. The subject of the study: serum leptin content and polymorphism of the leptin receptor gene LEPRGln223Arg in patients with metabolic fatty liver disease and alcoholic liver disease. The investigation methods. A comparative analysis of the serum leptin level and polymorphism of the leptin receptor gene LEPRGln223Arg was carried out in 108 patients with metabolic fatty liver disease and in 80 patients with alcoholic liver disease with an assessment of body mass index, lipid metabolism, and gender differences. Results. Reliable differences in serum leptin content and the frequency of genotypes of the leptin receptor gene LEPRGln223Arg were revealed in patients with metabolic fatty liver disease and alcoholic liver disease. The results obtained can serve as additional differential diagnostic criteria between metabolic fatty liver disease and alcoholic liver disease in the early stages. Conclusion. The results obtained confirm hyperleptinemia in patients with metabolic fatty liver disease exceeding that in patients with alcoholic liver disease. Leptin resistance in men and women with metabolic fatty liver disease is associated with different genotypes of the leptin receptor gene LEPRGln223Arg. No similar association of the genotypes of the leptin receptor gene LEPRGln223Arg was found in patients with alcoholic liver disease.

About the Authors

O. A. Morozova
Novokuznetsk State Institute for Further Training of Physicians
Russian Federation


A. V. Morozova
Novokuznetsk State Institute for Further Training of Physicians
Russian Federation


References

1. European Association for the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for Study of Obesity (EASO). EASL-EASD-EASO Clinical Practice Guidelines for management of non-alcoholic fatty liver disease. J Hepatol. 2016;64(6):1388-402. doi: 10.1016/j.hep.2015/11/004.

2. Mc Cullough A.J. The epidemiology and risk factors of NASH. Hepatology. 2013;58(5):1644-54.

3. Ivashkin V.T., Mayevskaya M.V., Pavlov Ch.S. et al. Clinical guidelines for the diagnosis and treatment of non - alcoholic fatty liver disease of the Russian Society for the Study of the Liver and the Russian Gastroenterological Association.Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2016;26(2):24-42. (in Russ.) doi: 22416/1382-4376-2016-26-2-24-42.@@ Ивашкин В.Т., Маевская М.В., Павлов Ч.С. и др. Клинические рекомендации по диагностике и лечению неалкогольной жировой болезни печени Российского общества по изучению печени и Российской гастроэнтерологической ассоциации. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2016;26(2):24-42. doi: 22416/1382-4376-2016-26-2-24-42.

4. Obika M., Noguchi H. Diagnosis and evaluation of nonalcoholic fatty liver disease. Exp Diabetes Res. 2012;2012:145754. doi: 10.1155/2012/145754.

5. Ong J.P., Younossi Z.M. Epidemiology and natural of NAFLD and NASH. Clin Liver Dis. 2007;11:1. doi: 10.1016/j.cld.2007.02.009.

6. Kleiner D.E., Makhlouf H.R. Histology of Nonalcoholic Fatty Liver Disease and Nonalc oholic Steatohepatitis in Adults and Children. Clin Liver Dis. 2016;20(2):293-312. doi: 10.1016/j.cid.2015.10.011.

7. Lazebnik L.B., Golovanova E.V., Eremina E. Yu. et al. Clinical recommendations: alcoholic liver disease in adult. Thearapy. 2020;6(4-38):10-35. (in Russ.) doi: 10.18565/therapy.2020.4/10-35.@@ Лазебник Л.Б., Голованова Е.В., Еремина Е.Ю. и др. Клинические рекомендации: алкогольная болезнь печени у взрослых. Терапия. 2020. Т 6. № 4 (38). С. 10-35.

8. Fang Y.L., Chen H., Wang C.L., Liang L. Pathogenesis of non- alcoholic fatty liver disease in children and adolescence: from «two hit theory» to «multiple hit model». World J Gastroenterol. 2018;24:2974-83. doi: 10.3748/wjg.v24.i27.2974.

9. Gerok V., Blum Kh.E. [Diseases of the liver and biliary system]. Moscow. MEDpress-inform, 2009. (in Russ.)@@ Герок В., Блюм Х.Е. Заболевания печени и желчевыделительной системы. М.: МЕДпресс - информ, 2009.

10. Livzan M.A., Kolbina M.V., Matoshina I.V. et al. [Hormones adipose tissue and non-alcoholic fatty liver disease at metabolic syndrome]. Dnevnik kazanskoy meditsinskoy shkoly. 2014;(1):44-8. (in Russ.)@@ Ливзан М.А., Колбина М.В., Матошина И.В. и др. Гормоны жировой ткани и неалкогольная жировая болезнь печени при метаболическом синдроме // Дневник казанской медицинской школы. 2014. № 1. С. 44-48.

11. Fletcher R., Fletcher S., Wagner E. [Clinical epidemiology. Fundamentals of evidence-based medicine]. Moscow. Media Sphere,1998. (in Russ.)@@ Флетчер Р., Флетчер С., Вагнер Э. Клиническая эпидемиология. Основы доказательной медицины. М. Медиа Сфера, 1998.

12. Zhang C., Guo L., Guo X.Interaction of polymorphisms genes of Leptin receptor gene Gln223Arg, MnSOD9Ala/Val genes and smoking in nonalcoholic fatty liver disease. Wei Sheng Yan Jiu. 2014;43(5):724-31.

13. Vajro P., Lenta S., Socha P., Dhawan A. et al. Diagnosis of nonalcoholic fatty disease in children and adolescents: position paper of the ESPGHAN Hepatology Committee. Pediatr Gastroenterol Nutr. 2012;54:700-713.

14. Friedman J. Leptin at 20: an overview. J Endocrinol. 2014;223:1-8. doi: 10.1530/JOE-14-0405.

15. Kytikova O. Yu., Novgorodtseva T.P., Denisenko Yu.K., Kovalevsky D.A. Metabolic and genetic determinants of lipid metabolism disruption in non-alcoholic fatty liver disease.Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2020;30(2):15-25. (in Russ.) doi: 10.22416/1382-4376-2020-30-2-15-25.@@ Кытикова О.Ю., Новгородцева Т.П., Денисенко Ю.К., Ковалевский Д.А. Метаболические и генетические нарушения липидного обмена при неалкогольной жировой болезни печени. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2020. Т. 30, № 2. С. 15-25. doi: 10.22416/1382-4376-2020-30-2-15-25.

16. Schiff Y.R., Sorrell M.F., Maddray W.S. [Alcoholic, medicinal, genetic and metabolic diseases]. Moscow. GEOTAR-Media, 2011 (In Russ.)@@ Шифф Ю.Р., Соррел М.Ф., Мэддрей У.С. Алкогольные, лекарственные, генетические и метаболические заболевания печени; пер. с англ. М.: ГЕОТАР - Медиа, 2011.

17. Ben A.S., Kallel A., Sediri Y. et al. LEPR p.Q223R Polymorphism influences plasma leptin levels and body mass index in Tunisian obese patients. Arch Med Res. 2009;40(3):186-190. doi: 10 1016/j.arcmed.2009.02.008.

18. Angulo P. at al. Fibrosis, but no Other Histologic Features Associates with Long-tern Outcomes of Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology. 2015 Aug; 149 (2): 389-397.e10. doi: 10.1053/j.gastro.2015.04.0443.

19. Li X.L., Sui J.Q., Lu L.L. et al. Gene polymorphisms associated with non-alcoholic fatty liver disease and coronary artery disease: a concise review. Lipids Health Dis. 2016;15:53. doi: 10.1186/s12944-016-0221-8.

20. Akhmedov V.A., Melikov T.I. Genetic aspects of the formation of non-alcoholic fatty liver disease. The Attending Physician. 2019;8:28-31. (in Russ.)@@ Ахмедов В.А., Меликов Т.И. Генетические аспекты формирования неалкогольной жировой болезни печени. Лечащий врач, 2019;8:28-31.

21. Dongiovanni P., Romeo S., Valenti L. Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis. BioMed Research International. 2015;460190. doi: 10.1155/2015/460190.

22. Glants S. Medico - biological statistics. Moscow. Practice, 1998. (in Russ.)@@ Гланц С. Медико-биологическая статистика. М.: Практика,1998.)

23. Di Maira G., Pastore M., Marra F. Liver fibrosis in the context of nonalcoholic steatohepatitis: the role of adipokines. Minerva Gastroenterol Dietol. 2018;64:39-50. doi: 10.23736/S1121-421X.17.022427-8.


Review

For citations:


Morozova O.A., Morozova A.V. Differential diagnostic value of serum leptin level and polymorphism of the leptin receptor gene Gln223Arg in metabolic fatty and alcoholic liver diseases. Experimental and Clinical Gastroenterology. 2024;(10):155-161. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-230-10-155-161

Views: 3


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1682-8658 (Print)