The role of systemic inflammation in the progression of periodontal diseases, cardiovascular disease and metabolic syndrome
https://doi.org/10.31146/1682-8658-ecg-231-11-150-156
Abstract
Periodontal tissue diseases are among the most common diseases of the oral cavity and, along with dental caries, constitute the main cause of tooth loss. Cardiovascular and metabolic diseases, as the most common causes of mortality throughout the world, are, in turn, considered one of the most socially significant diseases. Common factors that contribute to the development of periodontal disease and cardiovascular and metabolic disease include aging, smoking, alcohol abuse, race/ethnicity, educational level and socioeconomic status, male gender, diabetes mellitus and overweight or obesity, and inflammation. Inflammation is a well-organized protective response to pathogens and involves the recruitment of recruited immune cells to sites of infection. Either the inflammatory process eliminates pathogens and resolves, leading to tissue healing, or remains predominantly unresolved, causing pathological processes in organs. However, failure to shut down the inflammatory cascade after removal of the pathogenic stimulus results in chronic inflammation (i. e., an uncontrolled inflammatory response that can lead to host tissue damage) and is a hallmark of several pathologies associated with inflammatory disorders. Particularly in periodontal disease, the inflammatory response becomes chronic when pathogenic bacteria continue to multiply and cannot be controlled by the acute immune response, resulting in unresolved inflammation, destruction of the periodontium or the supporting tissues of the teeth (gingival tissue, periodontal ligament and alveolar bone). The review article presents data from scientific studies devoted to the study of the systemic inflammatory component in the mutually directed development of diseases of periodontal tissue, the cardiovascular system, and metabolic pathology.
About the Author
A. I. Sabirova
State Educational Institution of Higher Professional Education Kyrgyz-Russian Slavic University named after the first President of the Russian Federation B.N. Yeltsin
Russian Federation
Russian Federation
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For citations:
Sabirova A.I. The role of systemic inflammation in the progression of periodontal diseases, cardiovascular disease and metabolic syndrome. Experimental and Clinical Gastroenterology. 2024;(11):150-156. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-231-11-150-156
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