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Comparative pathomorphological picture of various experimental models of gastric ulcer disease

https://doi.org/10.31146/1682-8658-ecg-231-11-113-118

Abstract

The aim of the study was to evaluate the pathomorphological picture of experimental models of gastric ulcer obtained by intragastric administration of ethanol of various concentrations, wormwood bitter herb tincture, as well as prednisone. Materials and methods. The experiment was conducted on 5 experimental groups of 5 stock Wistar rats. Gastric ulcer was modeled by a single injection of 96% and 70% ethanol, wormwood bitter herb tincture made with 70% ethanol, as well as 4- and 7-day administration of prednisone. Ulcerogenic agents were administered intragastrically, ethanol and wormwood bitter herb tincture at a dose of 5 ml / kg, prednisolone at a dose of 20 mg / kg. A pathomorphological study of the stomachs of experimental rats was performed at the macro- and microscopic level. Results. With intragastric administration of 96% and 70% ethanol, as well as wormwood bitter herb tincture, there is a pronounced formation of erosions with an average depth of 358.5 ± 29.7, 199.9 ±22.0 and 307.8 ± 7.5 microns, respectively, the development of foci of thrombosis and diapedetic hemorrhages, as well as necrotic-dystrophic lesions, most pronounced with the introduction of 96% ethanol. Against the background of 7-day intragastric administration of prednisolone, a significant ulcer with an average erosion depth of 164.8 ± 10.8 microns is formed in the absence of pathological changes with 4-day administration. Conclusion. The pathomorphological picture of gastric ulcer with the introduction of 70% ethanol is characterized by significant erosion with less pronounced tissue necrosis compared with 96% ethanol. The introduction of wormwood bitter herb tincture is characterized by a tendency to form erosion of coolant of greater depth than against the background of the introduction of 70% ethanol. Intragastric administration of prednisone for 7 days makes it possible to reliably obtain erosive damage to the stomach.

About the Authors

A. Yu. Zharikov
Altai State Medical University
Russian Federation


O. N. Mazko
Altai State Medical University
Russian Federation


I. P. Bobrov
Altai State Medical University
Russian Federation


A. S. Kalnitsky
Altai State Medical University
Russian Federation


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Review

For citations:


Zharikov A.Yu., Mazko O.N., Bobrov I.P., Kalnitsky A.S. Comparative pathomorphological picture of various experimental models of gastric ulcer disease. Experimental and Clinical Gastroenterology. 2024;(11):113-118. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-231-11-113-118

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