Celiac disease in children with diabetes: how not to miss it?

The pathogenesis of celiac disease is characterized by its frequent association with autoimmune diseases, in particular, with type 1 diabetes mellitus. Possible causes of the association include the presence of common genetic markers in patients, cross-reaction of autoantibodies and activated T-lymphocytes formed in celiac disease with the body’s own antigens, systemic effects of proinflammatory cytokines, and similar provoking environmental factors. Celiac disease associated with type 1 diabetes mellitus is characterized by a low-symptom or asymptomatic course, which leads to untimely diagnosis, increases the risk of complications of both diseases, reduces the effectiveness of diabetes control, and worsens the quality of life of patients. The only way to timely detect gluten enteropathy is to conduct regular screening for celiac disease among patients with diabetes.

celiac disease, children, gluten, type 1 diabetes mellitus, comorbidity, tissue transglutaminase, major histocompatibility complex genes HLA DQ2/DQ8, non-HLA genes, CD4+ lymphocytes, proinflammatory cytokines, selective IgA deficiency, gluten-free diet

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