Sarcopenia and COVID-19 - a complex pathological duet

March 11, 2020 The World Health Organization has declared the New Coronavirus Infection 2019 (COVID-19) a pandemic. The risk of complications in the acute period of COVID-19 was obvious almost immediately. However, back in 2020, during the onset and height of the pandemic, health professionals began to think about the possible negative long-term and delayed consequences of COVID-19. Until now, the world is facing the long-term consequences of COVID-19 among survivors, who often have multisystem pathological manifestations. The study of the consequences of COVID-19 continues to be an urgent problem of modern medical science. Currently, increased attention is being paid to sarcopenia, which occurred in patients after COVID-19. On the other hand, sarcopenia is a predictor of adverse outcomes in patients with new coronavirus infection. In 2020, a self-isolation regime (lockdown) was introduced in many countries as an effective anti-epidemic strategy. Unfortunately, the self-isolation regime has led to a decrease in physical activity, especially in elderly and senile people. Therefore, physical inactivity against the background of self-isolation itself was a risk factor for sarcopenia. In addition, during self-isolation, many patients experienced an increase in the caloric content of their diet and the development of obesity. Rehabilitation after COVID-19 necessarily includes measures for the prevention and treatment of sarcopenia. Thus, this literature review is devoted to the study of the relationship between sarcopenia and COVID-19.

sarcopenia, COVID-19, Long-COVID, Post-COVID-19 syndrome, chronic inflammation, senescence-associated secretory phenotype, SASP, cytokine storm, obesity, immunosuppression

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