Митохондриальный оксидативный стресс и болезни печени
https://doi.org/10.31146/1682-8658-ecg-228-8-143-157
Аннотация
Печень является важным органом обмена веществ и детоксикации и, следовательно, требует большого количества энергии, которая в основном вырабатывается митохондриями. Митохондриальный оксидативный стресс, который возникает, когда ферментативные и неферментативные антиоксиданты перегружаются активными формами кислорода (АФК), образующимися при различных патологических процессах. Это приводит к гепатоцеллюлярной дисфункции и, в конечном итоге, к фиброзу печени. Данный обзор посвящен современным представлениям патофизиологических основ митохондриального оксидативного стресса и его влиянию на развитие хронических заболеваний печени различной этиологии.
Об авторах
Г. В. Волынец
Федеральное государственное бюджетное образовательное учреждение высшего образования «Российский национальный исследовательский медицинский университет имени Н. И. Пирогова» Министерства здравоохранения Российской Федерации
Россия
Россия
А. И. Хавкин
ГБУЗ МО «Научно-исследовательский клинический институт детства Министерства здравоохранения Московской области»; Белгородский государственный исследовательский университет
Россия
Россия
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Рецензия
Для цитирования:
Волынец Г.В., Хавкин А.И. Митохондриальный оксидативный стресс и болезни печени. Экспериментальная и клиническая гастроэнтерология. 2024;(8):143-157. https://doi.org/10.31146/1682-8658-ecg-228-8-143-157
For citation:
Volynets G.V., Khavkin A.I. Mitochondrial oxidative stress and liver disease. Experimental and Clinical Gastroenterology. 2024;(8):143-157. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-228-8-143-157
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