Nonalcoholic fatty liver disease and chronic kidney disease: random connections or two manifestations of metabolic syndrome?
https://doi.org/10.31146/1682-8658-ecg-228-8-123-130
Abstract
Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) are two global public health problems that affect almost 30% and up to ~10-15%, respectively, of the general adult population in many parts of the world. It is quite obvious that NAFLD is a “multisystem disease” associated not only with impaired liver function and the development of hepatocellular carcinoma, but also with an increasing risk of developing cardiovascular diseases (the main cause of death in such patients), chronic kidney disease (CKD). However, the mechanisms underlying this association remain largely unknown. The aim of this review is to report on the epidemiology and pathophysiology of the relationship between NAFLD and CKD and to describe the different methods of kidney function assessment in patients with NAFLD as well as to discuss the potential for promising pharmacotherapy with simultaneous benefit for the outcomes of both diseases.
About the Authors
O. V. Khlynova
Perm State Medical University named after E. A. Wagner
Russian Federation
Russian Federation
N. S. Karpunina
Perm State Medical University named after E. A. Wagner
Russian Federation
Russian Federation
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For citations:
Khlynova O.V., Karpunina N.S. Nonalcoholic fatty liver disease and chronic kidney disease: random connections or two manifestations of metabolic syndrome? Experimental and Clinical Gastroenterology. 2024;(8):123-130. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-228-8-123-130
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