Экспериментальная и клиническая гастроэнтерология

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Objectives. New and effective drugs to improve liver function and fibrosis are urgently needed for patients with nonalcoholic steatohepatitis (NASH). This study examines the effectiveness of treatment of patients with NASH with the registered hepatoprotector, Ropren®. Methods. This observational study used Ropren® in a post-registration setting to treat 20 females (38-56 years) with chronic NASH unresponsive to standard treatment. Ropren® is a biopolymer made up of polyprenols (analogue of dolichol) isolated from the green verdure of spruce (Picea abies (L) Karst). Ropren® was given orally, three times a day (54 mg/day). Measurements before and after treatment included symptoms and blood biochemistry (triglycerides, high-density lipoproteins, low-density lipoproteins, alanine transaminase, aspartate transaminase, alkaline phosphatase and gamma-glutamyl-transpeptidase). Liver fibrosis was measured with indirect ultrasound elastometry. Results. After 12 weeks of Ropren® treatment, improvements were found for blood lipids and clinical and biochemical signs, including reductions in total cholesterol and triglycerides (p < 0.05). Ropren® also significantly decreased the liver fibrosis index (p < 0.05). No side effects were observed. Conclusions. Ropren® treatment increased the elasticity of the liver and might be useful to reduce the risk of cirrhosis. Although the sample size in this study was small, the results demonstrated that a randomised-controlled trial of Ropren® for NASH is warranted.

Об авторах

Е. В. Голованова
Московский государственный медико-стоматологический университет им. А.И. Евдокимова

Н. А. Шапошникова
Государственное бюджетное учреждение города Москвы Московский клинический научный центр Департамента Здравоохранения города Москвы

Е. С. Мелькина
Государственное бюджетное учреждение города Москвы Московский клинический научный центр Департамента Здравоохранения города Москвы

В. С. Султанов
Федеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный лесотехнический университет имени С.М. Кирова»; Пренолика Лимитед, Биотехнологическая компания

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Для цитирования:

Голованова Е.В., Шапошникова Н.А., Мелькина Е.С., Султанов В.С. ГЕПАТОПРОТЕКТОР РОПРЕН ДЛЯ ЛЕЧЕНИЯ БОЛЬНЫХ С НЕАЛКОГОЛЬНЫМ СТЕАТОГЕПАТИТОМ: ОБСЕРВАЦИОННОЕ ПРОГРЕССИВНОЕ ИССЛЕДОВАНИЕ. Экспериментальная и клиническая гастроэнтерология. 2016;(9):71-76.

For citation:

Golovanova E.V., Shaposhnikova N.A., Melkina E.S., Soultanov V.S. THE HEPATOPROTECTOR ROPREN FOR THE TREATMENT OF PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS: A PROSPECTIVE OBSERVATIONAL STUDY. Experimental and Clinical Gastroenterology. 2016;(9):71-76. (In Russ.)

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