Features of the course of the new coronavirus infection COVID-19 in chronic kidney disease
https://doi.org/10.31146/1682-8658-ecg-227-7-29-36
Abstract
Purpose of the study. Study of the characteristics of the course of the new coronavirus infection COVID-19 in chronic kidney disease (CKD). Materials and methods. A total of 182 patients who were in the State Budgetary Institution “Emergency Medical Care Hospital” (Cheboksary) with a confirmed diagnosis of COVID-19 were examined. Results. A high incidence of CKD in hospitalized patients is shown. In CKD, there is a high mortality from COVID-19, statistically significant for CKD stage 3, but not for CKD stages 1-2. A number of clinical and laboratory parameters associated with an increased risk of adverse outcome have been identified. CKD is an independent risk factor that increases the risk of death when combined with these parameters. The positive effect of Janus kinase inhibitors is reflected when they are prescribed in the group under 65 years of age and in the first days of patient admission. Conclusion. The results of the study indicate the necessity of studying kidney function in patients with a new coronavirus infection. Patients with chronic kidney disease stages 3-4 require close dynamic monitoring as a risk group for severe disease, affecting survival.
About the Authors
A. S. Abyzov
Chuvash State University n. b. I. N. Ulyanov
Russian Federation
Russian Federation
V. A. Kichigin
Chuvash State University n. b. I. N. Ulyanov
Russian Federation
Russian Federation
L. V. Tarasova
Chuvash State University n. b. I. N. Ulyanov
Russian Federation
Russian Federation
References
1. Berlin D.A., Gulick R. M., Martinez F. J. Severe Covid-19. N Engl J Med. 2020 Dec 17;383(25):2451-2460. doi: 10.1056/NEJMcp2009575.
2. Hu B., Guo H., Zhou P. et al. Characteristics of SARS-CoV-2 and COVID-19. Nat Rev Microbiol. 2021;19(3):141-154. doi: 10.1038/s41579-020-00459-7.
3. Fisun A. Ya., Cherkashin D. V., Tyrenko V. V. et al. The role of the renin-angiotensin-aldosterone system in the interaction with the SARS-CoV-2 coronavirus and in the development of strategies for the prevention and treatment of new coronavirus infection (COVID-19). Arterial hypertension. 2020;26(3):248-262. (In Russ.) doi: 10.18705/1607-419X-2020-26-3-248-262.@@ Фисун А. Я., Черкашин Д. В., Тыренко В. В. с соавт. Роль ренин-ангиотензин-альдостероновой системы во взаимодействии с коронавирусом SARS-CoV-2 и в развитии стратегий профилактики и лечения новой коронавирусной инфекции (COVID-19). Артериальная гипертензия. 2020;26(3):248-262. doi: 10.18705/1607-419X-2020-26-3-248-262.
4. Cheburkin Yu. V., Sonin D. L., Polozov A. S. et al. The role of membrane and circulating forms of ACE 2 in the development of various pathological processes against the background of COVID -19. Arterial hypertension. 2021;27(6):608-616. (In Russ.) doi: 10.18705/1607-419X-2021-27-6-608-616.@@ Чебуркин Ю. В., Сонин Д. Л., Полозов А. С. c cоавт. Роль мембранной и циркулирующей форм ACE 2 в развитии различных патологических процессов на фоне COVID-19. Артериальная гипертензия. 2021;27(6):608-616. doi: 10.18705/1607-419X-2021-27-6-608-616.
5. Huang C., Wang Y., Li X. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5.
6. Feng S., Wang F., Wu W. et al. Analysis of multiple organ function damage in patients with severe COVID-19 pneumonia. J Med Biochem. 2023 Aug 25;42(3):444-453. doi: 10.5937/jomb0-41502.
7. Nalbandian A., Sehgal K., Gupta A. et al. Post-acute COVID-19 syndrome. Nat Med. 2021 Apr;27(4):601-615. doi: 10.1038/s41591-021-01283-z.
8. Zsichla L., Müller V. Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors. Viruses. 2023 Jan 7;15(1):175. doi: 10.3390/v15010175.
9. Li J., He X., Yuan Yuan. et al. Meta-analysis investigating the relationship between clinical features, outcomes, and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. Am J Infect Control. 2021 Jan;49(1):82-89. doi: 10.1016/j.ajic.2020.06.008.
10. Li Z., Ming Wu., Jiwei Yao. et al. Caution on kidney dysfunctions of COVID-19 patients. medRxiv. 2020.;1:1-25. doi: 10.1101/2020.02.08.20021212.
11. Yang Q., Yang X. Incidence and risk factors of kidney impairment on patients with COVID-19: A meta-analysis of 10180 patients. PLoS One. 2020 Nov 16;15(11): e0241953. doi: 10.1371/journal.pone.0241953.
12. Ahmadian E., Hosseiniyan Khatibi S. M., Razi Soofiyani S. et al. Covid-19 and kidney injury: Pathophysiology and molecular mechanisms. Rev Med Virol. 2021 May;31(3): e2176.doi: 10.1002/rmv.2176.
13. Pei G., Zhang Z., Peng J. et al. Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia. J Am Soc Nephrol. 2020 Jun;31(6):1157-1165. doi: 10.1681/ASN.2020030276.
14. Kunutsor S.K., Laukkanen J. A. Renal complications in COVID-19: a systematic review and meta-analysis. Ann Med. 2020 Nov;52(7):345-353. doi: 10.1080/07853890.2020.1790643.
15. Adapa S., Chenna A., Balla M. et al. COVID-19 Pandemic Causing Acute Kidney Injury and Impact on Patients With Chronic Kidney Disease and Renal Transplantation. J Clin Med Res. 2020 Jun;12(6):352-361. doi: 10.14740/jocmr4200.
16. Chung E.Y.M., Palmer S. C., Natale P. et al. Incidence and Outcomes of COVID-19 in People With CKD: A Systematic Review and Meta-analysis. Am J Kidney Dis. 2021 Dec;78(6):804-815. doi: 10.1053/j.ajkd.2021.07.003.
17. Henry B.M., Lippi G. Chronic kidney disease is associated with severe coronavirus disease 2019 (COVID-19) infection.Int Urol Nephrol. 2020 Jun;52(6):1193-1194. doi: 10.1007/s11255-020-02451-9.
18. Shahid Z., Kalayanamitra R., McClafferty B. et al. COVID-19 and Older Adults: What We Know. J Am Geriatr Soc. 2020 May;68(5):926-929. doi: 10.1111/jgs.16472.
19. Oyelade T., Alqahtani J., Canciani G. Prognosis of COVID-19 in Patients with Liver and Kidney Diseases: An Early Systematic Review and Meta-Analysis. Trop Med Infect Dis. 2020 May 15;5(2):80. doi: 10.3390/tropicalmed5020080.
20. Jdiaa S.S., Mansour R., El Alayli A. et al. COVID-19 and chronic kidney disease: an updated overview of reviews. J Nephrol. 2022 Jan;35(1):69-85. doi: 10.1007/s40620-021-01206-8.
21. Holman N., Knighton P., Kar P. et al. Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study. Lancet Diabetes Endocrinol. 2020 Oct;8(10):823-833. doi: 10.1016/S2213-8587(20)30271-0.
22. Williamson E.J., Walker A. J., Bhaskaran K. et al. Factors associated with COVID-19-related death using OpenSAFELY. Nature. 2020 Aug;584(7821):430-436. doi: 10.1038/s41586-020-2521-4.
23. Prevention, diagnosis and treatment of novel coronavirus infection (COVID-19): Interim guidelines. Version 14 (December 27, 2021). Ministry of Healthcare of Russia. (In Russ.) Available at: https://static-minzdrav.gov.ru/system/attachments/attaches/000/059/041/original/ВМР_COVID-19_V14_27-12-2021.pdf (date of access - 01.09.2023)@@ Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19): временные методические рекомендации. Версия 14 (27.12.2021). Минздрав России. Доступ: https://static-minzdrav.gov.ru/system/attachments/attaches/000/059/041/original/ВМР_COVID-19_V14_27-12-2021.pdf (дата обращения - 01.09.2023).
24. Kellum J.A., Lameire N., Aspelin P. et al. Kidney disease: Improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury. Kidney International Supplements, 2(1), 1-138. doi: 10.1038/kisup.2012.1.
25. Batyushin M.M., Gavrilov D. V., Gusev A. V. et al. The prevalence of chronic kidney disease according to the retrospective cohort study «Epidemiology of CKD» (Kirov city). Nefrologiya i dializ = Nephrology and Dialysis. 2021; 23(2): 192-203 (In Russ.). doi: 10.28996/2618-9801-2021-2-192-202.@@ Батюшин М. М., Гаврилов Д. В., Гусев А. В. с соавт. Распространенность хронической болезни почек по данным ретроспективного когортного исследования. «Эпидемиология ХБП» (город Киров). Нефрология и диализ. 2021; 23(2): 192-203. doi: 10.28996/2618-9801-2021-2-192-202.
26. Batyushin M.M., Trubnikova M. A., Tarlovskaya E. I. et al. The effect of kidney damage on the course and prognosis of COVID-19 infection according to the international registry «Analysis of the dynamics of comorbid diseases in patients who have been infected with SARS-CoV-2». Arkhiv vnutrenney meditsiny = The Russian Archives of Internal Medicine. 2023; 13(2): 116-128 (In Russ.) doi: 10.20514/2226-6704-2023-13-2-116-128.@@ Батюшин М. М., Трубникова М. А., Тарловская Е. И. с соавт. Влияние поражения почек на течение и прогноз при инфекции COVID- 19 по данным международного регистра «Анализ динамики коморбидных заболеваний у пациентов, перенесших инфицирование SARS-CoV-2». Архивъ внутренней медицины. 2023; 13(2): 116-128. doi: 10.20514/2226-6704-2023-13-2-116-128.
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For citations:
Abyzov A.S., Kichigin V.A., Tarasova L.V. Features of the course of the new coronavirus infection COVID-19 in chronic kidney disease. Experimental and Clinical Gastroenterology. 2024;(7):29-36. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-227-7-29-36
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