Assessment of the role of adipocytokines in patients with psoriatic arthritis combined with non-alcoholic fatty liver disease
https://doi.org/10.31146/1682-8658-ecg-224-4-50-53
Abstract
The article presents the results of a clinical observation assessing the role of adipocytokines in patients with psoriatic arthritis (PsA) combined with non-alcoholic fatty liver disease. 50 patients with PsA and 70 patients with PsA and NAFLD were comprehensively examined. When psoriatic arthritis was combined with non-alcoholic fatty liver disease, pronounced skin-articular syndrome, high activity, progression of radiological changes and low effectiveness of standard treatment were observed. In patients with psoriatic arthritis with non-alcoholic fatty liver disease, adiponectin levels were found to decrease by 1.6 times and leptin concentrations to increase by 1.4 times compared to control values. The identified changes in the level of adipocytokines may have contributed to the progression of the disease and functional joint failure.
About the Authors
Kh. T. Mirakhmedova
Tashkent Medical Academy
Russian Federation
Russian Federation
M. T. Rustamova
Tashkent Medical Academy
Russian Federation
Russian Federation
N. R. Mukhsimova
Tashkent Medical Academy
Russian Federation
Russian Federation
S. S. Khairullaeva
Tashkent Medical Academy
Russian Federation
Russian Federation
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Review
For citations:
Mirakhmedova Kh.T., Rustamova M.T., Mukhsimova N.R., Khairullaeva S.S. Assessment of the role of adipocytokines in patients with psoriatic arthritis combined with non-alcoholic fatty liver disease. Experimental and Clinical Gastroenterology. 2024;(4):50-53. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-224-4-50-53
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