PREVALENCE AND PECULIARITY OF CORPUS ATROPHIC GASTRITIS IN POPULATION WITH HIGH LEVEL OF HELICOBACTER PYLORI INFECTION

Background: Corpus atrophic gastritis (СAG) may be the outcome of Helicobacter pylori (H.pylori) - infection or autoimmune damage of the parietal system, affecting the risk of gastric cancer and requiring different approaches in the treatment and observation. Aim: To study the prevalence and peculiarity of CAG in population with high prevalence of H.pylori infection. Materials and methods: Prevalence of CAG was studied in the representative group of Novosibirsk citizens (246 subjects aged 45-69, 117 males and 129 females) using serology for noninvasive testing of gastritis phenotype GastroPanel. Pepsinogen I (PgI) level < 30 µg/l and/or PgI/PgII ratio < 3.0 were interpreted as sever atrophy. In addition, a clinical group with serologically proven corpus atrophy was studied: 39 females and 8 males aged 38-79. Upper endoscopy and morphological examination was performed in 38 patients. As a pilot project, in 19 patients with suspicion on autoimmune gastritis (AIG) (low PgI + high Gastrin-17) parietal cells antibodies (PCA) and vitamin B12 level were determined. Conclusion: In Novosibirsk population prevalence of both H.pylori infection and CAG (10.2%) is high. AIG is often associated with H.pylori infection (in 47.4% of cases); however, its role demands a further evaluation. Autoimmune phenotype of gastritis which was found using noninvasive diagnostic was confirmed with the presence of PCA. In all cases of AIG atrophy was confirmed morphologically with the presence of intestinal metaplasia in 52.6% and dysplasia in 10.5% of cases.

corpus atrophic gastritis, autoimmune gastritis, pepsinogens, gastrin-17, antibodies to parietal cells, antibodies to H.pylori

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