EVOLUTION OF VIEWS ON THE PATHOGENESIS OF INFL AMMATORY BOWEL DISEASE
Abstract
Based on the literature overview and summarizing of practical experience we provides a current review of data regarding the epidemiology, etiology and pathogenesis of IBD. In this review authors focuse their attention on different links of the immune system, including the components of the innate immune system (macrophages, monocytes, neutrophils, dendritic cells), adaptive or acquired immunity (T and B cells), secreted mediators (cytokines and chemokines), as well as the cells of the intestinal epithelium and congenital limphoid cells, because according to modern concepts, elements of this system are the key factors of understanding the pathogenesis of IBD.
About the Authors
L. P. Sizyakina
Rostov State medical university
Russian Federation
Russian Federation
G. N. Tarasova
Rostov State medical university
Russian Federation
Russian Federation
N. V. Dobaeva
Rostov State medical university
Russian Federation
Russian Federation
References
1. Ott C., Schölmerich J. Extraintestinal manifestations and complications in IBD // Nat Rev Gastroenterol Hepatol. - 2013. - Vol.10, N10. - P. 585-95.
2. Assadsangabi A., Lobo A. J. Diagnosing and managing inflammatory bowel disease // Practitioner. 2013. - Vol. 257. - P. 1763.
3. Ильяшенко М. Г., Тарасова Г. Н., Бурцев Д. В. Клиническая информативность содержания альфа- и бета-дефензинов в биологических средах у больных язвенным колитом // Журнал экспериментальной и клинической гастроэнтерологии. - 2013. - № 9. - С. 29-33.
4. Lennon G., Balfe A., Earley H., et al. Influences of the colonic microbiome on the mucous gel layer in ulcerative colitis // Gut Microbes. - 2014 May-Jun. - Vol. 5, N3. - P. 277-85.
5. Geremia A., Biancheri P., Allan P., et al. Innate and adaptive immunity in inflammatory bowel disease // Autoimmun Rev. - 2014 Jan. - Vol. 13, N1. - P. 3-10.
6. Satokari R., Scand J. Contentious host-microbiota relationship in inflammatory bowel disease - can foes become friends again? // Gastroenterol. -2015. - Vol. 50, N1. - P. 34-42.
7. Gyires K., Tóth É. V., Zádori S. Z., et al. Gut inflammation: current update on pathophysiology, molecular mechanism and pharmacological treatment modalities // Curr Pharm Des. - 2014. - Vol. 20, N7. - P. 1063-81.
8. Hogan S. P., Waddell A., Fulkerson P. C., et al. Eosinophils in infection and intestinal immunity// Curr Opin Gastroenterol. - 2013 Jan. - Vol. 29, N1. - P. 7-14.
9. Cooney R., Jewell D., et al. The genetic basis of inflammatory bowel disease// Dig Dis. - 2009. - Vol. 27, N4. - P. 428-42.
10. Peters C. P., Mjösberg J. M., Bernink J. H., et al. Innate lymphoid cells in inflammatory bowel diseases// Immunol Lett. - 2016 Apr. - Vol. 172. - P. 124-31.
11. Pierdomenico M., Stronati L, Costanzo M, et al. New insights into the pathogenesis of inflammatory bowel disease: transcription factors analysis in bioptic tissues from pediatric patients// J Pediatr Gastroenterol Nutr. - 2011 Mar;52(3):271-9.doi: 10.1097/MPG.0b013e3182034d08.
12. Antoni L., Nuding S., Wehkamp J., et al. Intestinal barrier in inflammatory bowel disease// World J Gastroenterol. - 2014 Feb. - Vol. 20, N5. - P. 1165-79.
13. Gersemann M., Wehkamp J., Stange E. F., et al. Innate immune dysfunction in inflammatory bowel disease // J Intern Med. - 2012. May. - Vol. 271, N5. - P. 421-8.
14. Ostaff M. J. Stange E. F., Wehkamp J., et al. Antimicrobial peptides and gut microbiota in homeostasis and pathology// EMBO Mol Med. -2013 Oct. - Vol. 5, N10. - P. 1465-83.
15. Johansson M. E.V., Phillipson M., Petersson J., et al. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria// Proc Natl Acad Sci U S A. - 2008. - Vol. 105. - P. 15064-9.
16. Siggers R. H., Hackam D. J. The role of innate immune-stimulated epithelial apoptosis during gastrointestinal inflammatory diseases// Cell Mol Life Sci. - 2011. - Vol. 68, N22. - P. 3623-34.
17. JP Jacobs at al. Immune and genetic gardening of the intestinal microbiome// FEBS Lett. 2014 Nov 17;588(22):4102-11. doi: 10.1016/j.febslet.2014.02.052. Epub 2014 Mar 5. Braun J
18. Мамедова Л. Н., Тарасова Г. Н. Новые возможности диагностики язвенного колита. - //Научная мысль Кавказа. - 2013. - № 1. - С. 176-178.
19. Szumilas D., Krysiak R, Okopień B., et al. The role of TLR4 receptor in development of inflammation and carcinogenesis in ulcerative colitis and pharmacotherapy of this disorder // Wiad Lek. - 2013. - Vol. 66, N1. - P. 3-9.
20. Opipari A., Franchi L. Role of inflammasomes in intestinal inflammation and Crohn’s disease// Inflamm Bowel Dis. - 2015. - Vol. 21, N1. - P. 173-81.
21. Shen W., Durum S. K. Synergy of IL-23 and Th17 cytokines: new light on inflammatory bowel disease// Neurochem Res. - 2010. - Vol. 35, N6. - P. 940-6.
22. Davies J. M. Neurath M. F. et al. The innate immune system and inflammatory bowel disease// Scand J Gastroenterol. - 2015. - Vol. 50, N1. - P. 24-33.
23. Mudter J. Il-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance. Inflamm Bowel Dis. - 2007. - Vol. 13, N8. - P. 1016-23.
24. Allocca M., Jovani M., Fiorino G., et al. Anti-IL-6 treatment for inflammatory bowel diseases: next cytokine, next target // Curr Drug Targets. - 2013. - Vol. 14, N12. - P. 1508-21.
Review
For citations:
Sizyakina L.P., Tarasova G.N., Dobaeva N.V. EVOLUTION OF VIEWS ON THE PATHOGENESIS OF INFL AMMATORY BOWEL DISEASE. Experimental and Clinical Gastroenterology. 2016;(8):57-61. (In Russ.)
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