TOWARD THE OPTIMAL SNP RESEARCH PANEL IN IRRITABLE BOWEL SYNDROME
Abstract
The genetic component of multifactorial diseases which include irritable bowel syndrome (IBS) is provided by single nucleotide polymorphisms (SNP) as usual. It is essential to detect the associations of polymorphisms with various pathologies, even if they are not causative factors. It can be used for diagnostic purposes and the development of drug therapies. Analyses of individual polymorphisms have not found their unique relationship with susceptibility to IBS. Possibly, several genetic risk factors, together with the influence of the environment cause a synergistic effect leading to the appearance of IBS certain phenotype. This paper presents a research panel of five SNP, which are hereditary factors for violations processes of innate immunity: CD14-159 C> T (rs2569190); TNF-α -308 G> A (rs1800629); IL17A -197 G> A (rs2275913); TLR2 Arg753Gln G> A (rs5743708); TLR4 Asp299Gly A> G (rs4986790). Results indicate genetically determined predisposition to IBS as the number of "rare" alleles in the test regions of genes CD14, TNF-α and TLR4. Carriage heterozygous genotype GA polymorphism IL17A -197 G>A is also a risk factor for IBS in the population studied. On the contrary, carriage of "rare" allele polymorphism Arg753Gln G>A TLR2 gene has to be protective, but normal - predictive properties in the context of the development of IBS.
About the Authors
E. V. Semenova
SFBI “Petersburg Nuclear Physics Institute”
Russian Federation
Russian Federation
A. V. Ivanov
University Hospital of Saint-Petersburg State University
Russian Federation
Russian Federation
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For citations:
Semenova E.V., Ivanov A.V. TOWARD THE OPTIMAL SNP RESEARCH PANEL IN IRRITABLE BOWEL SYNDROME. Experimental and Clinical Gastroenterology. 2016;(8):30-39. (In Russ.)
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