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Экспериментальная и клиническая гастроэнтерология

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Современные представления о влиянии микробиома кишечника на персистенцию ВИЧ-инфекции

https://doi.org/10.31146/1682-8658-ecg-217-9-195-200

Аннотация

В статье обсуждаются современные представления о влиянии ВИЧ-инфекции на микробиом кишечника, микробную транслокацию, системное хроническое воспаление и активацию иммунитета. В свою очередь, микробиом кишечника участвует в системном воспалении и активации иммунной системы, что способствует персистенции ВИЧ-инфекции. Хотя точный патогенез ВИЧ-инфекции и изменений микробиома кишечника (снижение бактериального разнообразия) пока неясен, нормализация микробиома кишечника при ВИЧ-инфекции может уменьшить воспаление, и тем самым привести к уменьшению возможного резервуара для ВИЧ-инфекции. Авторы статьи представили современные гипотезы о взаимодействии микробиома кишечника с системным воспалением, а также связи кишечного микробиома и персистенции ВИЧ-инфекции. Неспособность современных методов лечения воздействовать на скрытый вирусный резервуар и истощить его является основным препятствием на пути излечения от ВИЧ-инфекции. Обсуждаются предпринимаемые усилия по лечению, направленные на ликвидацию резервуаров ВИЧ-инфекции, с целью достижения стойкой ремиссии и возможности излечения от ВИЧ-инфекции.

Об авторах

А. А. Хрянин
ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России; РОО «Ассоциация акушеров-гинекологов и дерматовенерологов»
Россия


В. К. Бочарова
Первый Санкт-Петербургский государственный медицинский университет им. Павлова
Россия


Е. В. Пушкарев
ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России
Россия


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Рецензия

Для цитирования:


Хрянин А.А., Бочарова В.К., Пушкарев Е.В. Современные представления о влиянии микробиома кишечника на персистенцию ВИЧ-инфекции. Экспериментальная и клиническая гастроэнтерология. 2023;(9):195-200. https://doi.org/10.31146/1682-8658-ecg-217-9-195-200

For citation:


Khryanin A.A., Bocharova V.K., Pushkarev E.V. Modern ideas about the influence of the gut microbiome on the persistence of HIV infection. Experimental and Clinical Gastroenterology. 2023;(9):195-200. https://doi.org/10.31146/1682-8658-ecg-217-9-195-200

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