Conservatism and divergence in the semiotics cholelithiasis
https://doi.org/10.31146/1682-8658-ecg-204-8-63-69
Abstract
The aim of the study was to analyze the patterns associated with the risk of developing gallstone disease. Material and methods. The selection of signs of metabolic syndrome among patients of the hospital contingent with cholelithiasis, depending on gender and age, was carried out. There are 271 patients in the general population, of which 227 are women and 49 are men. Statistical processing of research results using the Statistica 8.0 applied software package. Results. Differences in etiology and pathogenesis lead to divergence of the phenotype of patients with cholelithiasis. At the same time, the conservatism of significant risk factors for the development of the disease remains. These include ethnic and sexual dimorphism: Caucasians are twice as likely to suffer from gallstone disease than the Khakass (7.3 and 3.4%, respectively). The incidence of gallstones in women is 8.6% (Caucasians - 10.9%; Khakaski - 6.2%). The indicators for women are 4.6 times higher than for men - 1.9% (Caucasians - 2.5%; Khakass - 1.3%). Older age: after 60 years, the number of patients increases exponentially, gender differences decrease. In the rating of comorbidities, the following are most often recorded: abdominal obesity (92.3% of patients), excess body weight (87.8%); violation of carbohydrate metabolism (86.4%), hypertension (81.7%), atherogenic dyslipidemia (50.6%) and NAFLD (23.6%). Conclusion. Together with conservative factors of susceptibility to gallstones that cannot be modified (age increase, female sex, heredity), a pathological phenotype known as metabolic syndrome is often formed. An increase in the frequency of gallstones is associated with variable combinations of metabolic syndrome components. Early detection of these signs can be used to predict and prevent the disease, since they are all modified to one degree or another. In addition, along with the conventional criteria for metabolic syndrome, the expression of gallstone disease has been established, which makes it possible to consider it a full-fledged sign.
About the Authors
O. V. Shtygasheva
Katanov Khakass State University
Russian Federation
Russian Federation
E. S. Ageeva
V. I. Vernadsky Crimean Federal University
Russian Federation
Russian Federation
S. V. Chmykhalo
Katanov Khakass State University
Russian Federation
Russian Federation
References
1. Tsukanov V.V., Shtygasheva O. V., Prevalence of cholelithiasis in the south of Eastern Siberia: materials of the Falk Symposium. New directions in hepatology. 1996; 92: 414. (In Russ.)@@ Цуканов, В.В., Штыгашева О. В., Распространенность холелитиаза на юге Восточной Сибири: материалы Фальк Симпозиума. Новые направления в гепатологии. 1996; 92: 414.
2. Tsukanov V.V., Shtygasheva O. V., Gorkovskaya I. A., Tonkich D. L. Cholelithiasis epidemiology in Siberia population. Abstracts of 11 World Congress of gastr. Digestion. 1998; 59(3): 560.
3. Shtygasheva O. V. On regional features of the prevalence of cholelithiasis in the world and in the south of Eastern Siberia. Bulletin of KhSU named after N. F. Katanov. Episode 4, Biology, Medicine, Chemistry. 1997; 4: 107-108. (In Russ.)@@ Штыгашева О. В. О региональных особенностях распространенности холелитиаза в мире и на юге Восточной Сибири. Вестник ХГУ им. Н. Ф. Катанова. Серия 4, Биология, медицина, химия. 1997; 4: 107-108.
4. International Diabetes Federation (IDF): Consensus on Metabolic Syndrome Criteria. World medicine news. 2005;2:47-49. (In Russ.)@@ Международная Федерация диабета (IDF): консенсус по критериям метаболического синдрома. Новости мировой медицины. 2005;2:47-49.
5. All-Russian Scientific Society of Cardiology. Recommendations of experts from the All-Russian Scientific Society of Cardiology for the diagnosis and treatment of metabolic syndrome. Second revision. Practical medicine. 2010;44(5):81-101. (In Russ.)@@ Рекомендации экспертов Всероссийского научного общества кардиологов по диагностике и лечению метаболического синдрома. Второй пересмотр. Практическая медицина. 2010;44(5):81-101.
6. NCEP-ATP III. The Journal of the American Medical Association. 2001;285:2486-2497.
7. Trifonova E. V. Cholelithiasis and blood lipid spectrum. Diary of Kazan Medical School. 2013;1:33-36. (In Russ.)@@ Трифонова Э. В. Желчекаменная болезнь и липидный спектр крови. Дневник казанской медицинской школы. 2013;1:33-36.
8. Algorithms for specialized medical care for patients with diabetes mellitus; edited by I. I. Dedova, M. V. Shestakova, A. Yu. Mayorov. M, 2019. 216 с. (In Russ.)@@ Алгоритмы специализированной медицинской помощи больным сахарным диабетом; под редакцией И. И. Дедова, М. В. Шестаковой, А. Ю. Майорова. М, 2019. 216 с.
9. Malyukova V.E., Zharikova T. S. Criteria for the formation of age groups of patients in medical research. Clinical medicine. 2015;11: 5-11. (In Russ.)@@ Малюкова В. Е., Жарикова Т. С. Критерии формирования возрастных групп пациентов в медицинских исследованиях. Клиническая медицина. 2015;11: 5-11.
10. Oshchepkova S. Yu., Zyazeva I. P., Bozhinskaya E. S. The role of risk factors in the mechanism of gallstone formation depending on gender and age modern scientific research. XVII International scientific conference. pp. 171-174 (In Russ.) @@ Ощепкова С. Ю., Зязева И. П., Божинская Е. С. Роль факторов риска в механизме желчного камнеобразования в зависимости от пола и возраста современные научные исследования. XVII International scientific conference. с. 171-174.
11. Vakhrushev Ya.M., Khokhlacheva N. A. Cholelithiasis: epidemiology, risk factors, clinical features, prevention. Archives of Internal Medicineю. 2016;3(29): 30-35 (In Russ.) doi: 10.20514/2226-6704-2016-6-3-30-35.@@ Вахрушев Я. М., Хохлачева Н. А. Желчнокаменная болезнь: эпидемиология, факторы риска, особенности клинического течения, профилактика. Архивъ внутренней медицины. 2016;3(29): 30-35 doi: 10.20514/2226-6704-2016-6-3-30-35.
12. Shtygasheva O.V., Ageeva E. S., Kharkov V. N., Stepanov V. A. Genes and diseases of the Khakass. Krasnoyarsk. Polikor, 2010. 296 p. (In Russ.)@@ Штыгашева О. В., Агеева Е. С., Харьков В. Н., Степанов В. А. Гены и болезни хакасов. Красноярск: Поликор, 2010. - 296 с.
13. Kim S. B., Kim K. H., Kim T. N., et al. Sex differences in prevalence and risk factors of asymptomatic cholelithiasis in Korean health screening examinee A retrospective analysis of a multicenter study. Medicine (Baltimore). 2017;96(13): e6477. doi: 10.1097/MD.0000000000006477
14. Siregar D. R., Muhar A. M., Pohan D. P. The role of cholelithiasis risk factors in stone types in cholelithiasis patients at Universitas Sumatera Utara Hospital Bali. Medical Journal (Bali MedJ). 2021;10 (1): 63-65.
15. Coelho J. C.U., Dalledone G. O., Schiel W., Berbardin J.de P., Claus C. M.P., Matias J. E.F., de Freitas A. C. T. Does male gender increase the risk of laparoscopic cholecystectomy? ABCD Arq Bras Cir Dig. 2019;32(2): e1438. doi: 10.1590/0102-672020190001e1438
16. Nikitin Yu.P., Grigorieva I. N. Female sex hormones and some other factors in the pathogenesis of gallstone disease. Therapeutic archive. 2005; 2: 89-92. (In Russ.)@@ Никитин Ю. П., Григорьева И. Н. Женские половые гормоны и некоторые другие факторы в патогенезе желчно-каменной болезни. Терапевтический архив. 2005;2: 89-92.
17. Klein S.L., Flanagan K. L. Sex differences in immune responses. Nature reviews. Immunology. 2016;16(10):626-638.
18. Klabukov I. D., Krasilnikova O. A., Lyundup A. V., Dyuzheva T. G. Immunological causes of gallstone disease (original hypothesis). Experimental and Clinical Gastroenterology. 2018;154(6): 134-142. (In Russ.)@@ Клабуков И. Д., Красильникова О. А., Люндуп А. В., Дюжева Т. Г. Иммунологическая природа желчекаменной болезни (гипотеза). Экспериментальная и клиническая гастроэнтерология. 2018;154(6): 134-142.
19. Sun H., Tang H., Jiang S., et al. Gender and metabolic differences of gallstone diseases. World J Gastroenterol. 2009;15:1886-91.
20. Petukhov V. A. Gallstone disease and indigestion syndrome. Moscow. Vedi, 2003; 125 p. (In Russ.)@@ Петухов В. А. Желчнокаменная болезнь и синдром нарушенного пищеварения. М.: Веди, 2003; 125 с.
21. Klabukov I. D., Lyundup A. V., Dyuzheva T. G., Tyakht A. V. Biliary microbiota and bile duct diseases. Annals of the Russian academy of medical sciences. 2017. vol. 72, no. 3, pp. 172-179 (In Russ.)@@ Клабуков И. Д., Люндуп А. В., Дюжева Т. Г., Тяхт А. В. Билиарная микробиота и заболевания желчных путей. Вестник Российской академии медицинских наук. 2017;72(3):172-179.
22. Ishiguro S., Inoue M., Kurahashi N., Iwasaki M., Sasazuki S., Tsugane S. Risk factors of biliary tract cancer in a large-scale population-based cohort study in Japan (JPHC study); with special focus on cholelithiasis, body mass index, and their effect modification. Cancer Causes Control. 2008;19:33-41.
23. Li L., Qiao X., Wang X., et al. The association between apolipoprotein E and gallstone disease: an updated meta-analysis Li et al. BMC Medical Genetics. (2019) 20:109. Doi: 10.1186/s12881-019-0843-6.
24. Brunquell J., Morris S., Snyder A., Westerheide S. D. Coffee extract and caffeine enhance the heat shock response and promote proteostasis in an HSF-1-dependent manner in Caenorhabditis elegans. Cell stress & chaperones. 2017.1-11.
25. Zhang Y.-P., Li W.-Q., Sun Y.-L., Zhu R.-T., Wang W.-J. Systematic review with meta-analysis: coffee consumpation and the risk of gallstone disease. Alimentary Pharmacology and Therapeutics. 2015. 42: 637-648.
Review
For citations:
Shtygasheva O.V., Ageeva E.S., Chmykhalo S.V. Conservatism and divergence in the semiotics cholelithiasis. Experimental and Clinical Gastroenterology. 2022;(8):63-69. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-204-8-63-69
Views:
247
Email this article 