Predicting the course and outcome of acute alcoholic-alimentary pancreatitis, taking into account the genetic status of the patient according to the polymorphic loci rs11546155 and rs6119534 of the GGT7 gene
https://doi.org/10.31146/1682-8658-ecg-204-8-35-40
Abstract
The aim of the study was to evaluate the role of the polymorphisms rs11546155 and rs6119534 of the GGT7 gene in predicting the risk of complications and outcome of AAP. The material of the study was DNA samples obtained from 471 patients with acute alcoholic-alimentary pancreatitis and 573 healthy individuals. The disease was diagnosed using clinical guidelines developed by the working group of the Russian Society of Surgeons. Statistical analysis was carried out using the Statistica 10.0 and the SNPStats programs. Results. The study found that for rs6119534 GGT7, the C/T genotype was associated with an increased risk of developing acute alimentary-alcohol pancreatitis (OR=1.94; 95% CI=1.41-2.68; P<0.0001); the T/T rs6119534 GGT7 genotype was over five times more common among patients with severe disease and was associated with an increased risk of infected pancreatic necrosis (OR=7.99; 95%CI 1.35-47.18; P=0.017). For rs11546155 GGT7, allele A was a predictor of an increased risk of developing pancreatic necrosis (OR=1.92; 95%CI 1.22-3.03; P=0.004); carriers of the A/A genotype had the highest level of leukocytes in the blood and a predisposition to the development of arrosive bleeding (OR=20.16; 95% CI 1.82-223.37; P=0.05); genotypes G/A-A/A were associated with an increased risk of infected pancreatic necrosis (OR=1.82; 95%CI 1.06-3.12; P=0.03). Conclusion. SNPs can be used as diagnostic and prognostic markers of AAP.
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For citations:
Samgina T.A. Predicting the course and outcome of acute alcoholic-alimentary pancreatitis, taking into account the genetic status of the patient according to the polymorphic loci rs11546155 and rs6119534 of the GGT7 gene. Experimental and Clinical Gastroenterology. 2022;(8):35-40. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-204-8-35-40
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