Пробиотики, постбиотики и парапробиотики
https://doi.org/10.31146/1682-8658-ecg-205-9-240-250
Аннотация
В последние годы в связи с широким внедрением молекулярно-генетических методов исследования кишечного микробиома и доказательства его роли в развитии многих социально-значимых заболеваний, стратегии воздействия на здоровье человека путем коррекции микробиоты и ее функций стали особенно востребованы. С этой целью обычно используют пробиотики, которые представляют собой живые микроорганизмы, которые улучшают здоровье хозяина. У них есть определенные показания и, в целом, хорошая переносимость. Но крайне редко их прием может осложняться развитием бактериемии, особенно у иммунокомпромиссных пациентов. Условие сохранения живых функционально активных бактерий не всегда достижимо. Это побуждает к поиску возможностей использования неживых бактериальных клеток, получивших название парапробиотиков, или компонентов микробных клеток и их метаболитов - постбиотиков. Исследования показывают, что парапробиотики по воздействию на иммунную систему и кишечный барьер не уступают эффекту пробиотиков, но отличаются лучшей сохранностью и безопасностью. Постбиотики также приближаются по многим параметрам к действию пробиотиков и отличаются большей стабильностью. Однако оптимальные технологии производства парапробиотиков и постбиотиков, а также показания к ним пока четко не разработаны. Это требует дальнейших исследований.
Об авторе
Елена Александровна Корниенко
ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства Здравоохранения Российской Федерации
Россия
Россия
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Рецензия
Для цитирования:
Корниенко Е.А. Пробиотики, постбиотики и парапробиотики. Экспериментальная и клиническая гастроэнтерология. 2022;(9):240-250. https://doi.org/10.31146/1682-8658-ecg-205-9-240-250
For citation:
Kornienko E.A. Probiotics, postbiotics and paraprobiotics. Experimental and Clinical Gastroenterology. 2022;(9):240-250. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-205-9-240-250
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