ROLE OF TGFβ-INDUCTION AND GASTROINTESTINAL MYOFIBROBLASTS IN PATHOMORPHOGENESIS OF CHRONIC GASTRITIS IN PATIENTS WITH MARFAN SYNDROME AND MARFAN-LIKE STATES

The aim was to explore the features of epithelial morphogenesis and reparation of gastric mucosa in chronic gastritis in patients with Marfan syndrome and Marfan -like states. Materials and methods. A histological evaluation and immunohistochemical analysis of the expression of antibodies against α-actin smooth muscle (α-SMA), collagen type III and transforming growth factor β (TGFβ) in the gastric mucosa in 50 patients with hereditary disorders of connective tissue between the ages of 17 to 41 years were performed. Results. In patients with Marfan syndrome and marfan-like states chronic gastritis was an unfavorable factor for the progression of the background atrophic and fibrotic processes in the gastric mucosa. It proved a key role disinhibited to TGFβ activity-dependent activation of fibrogenesis of subepithelial myofibroblasts (α-SMA +) with the development of a special morphogenetic variants of early chronic atrophic multifocal gastritis at a young age.

α-актин гладких миоцитов, chronic gastritis, atrophy of the gastric mucosa, Marfan syndrome, marfan-like state, myofibroblasts, transforming growth factor β (TGFβ), α-smooth muscle actin, collagen type III, hereditary disorders of connective tissue

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