Clinical and Epidemiological Characteristics of Acute Hepatitis B with Delta agent in Kyrgyzstan, 1999-2018
https://doi.org/10.31146/1682-8658-ecg-203-7-81-89
Abstract
Purpose of the research: study of clinical and epidemiological characteristics of Acute Hepatitis B with Delta agent (AHD) in Kyrgyzstan. Materials and Methods: State Reporting Forms No. 1 “Report on infectious and parasitic disease” for 1999-2018 were reviewed. The data of 115 patients with AHD were analyzed, who received inpatient treatment in 2000-2018, Bishkek. The data was processed by Epi Info 3.8.1. Results. In Kyrgyzstan, only AHD 129 cases (0,12 ‰00) were detected for the reviewed period, which was 97,7 times lower than the incidence of Delta free Acute Hepatitis B (AHB). Over the rime, the AHD incidence rate has decreased by 14,6 times with a base rate of decline at the level of 6,8%. The cumulative average AHD incidence in men was 2,4 times higher compared to women (0,17 ‰00 and 0,07 ‰00, men and women, respectively) and 1,4 times higher compared to the general population level. Analysis of clinical and laboratory data of 115 AHD patients indicated that the disease was associated with medical interventions in 61,7% ± 4,5 patients (71/115). The most frequently reported causes of infection were surgical and dental interventions (50,7% ± 5,9 and 35,2% ± 9,5, respectively). Of the analyzed 109 cases in the age group 16+, 60 patients (55%) had AHD as co-infection, and 49 (45%) - as superinfection. 30% of patients (33/109) had a severe course, which was twice as common in patients with superinfection (43%, 21/49). Conclusion: The low incidence of AHD with the still high prevalence of hepatitis B in the country, the presence of AHD “superinfection” in half of the observed patients with HBsAg-positive status does not reflect the true epidemiological situation and indicates the need to examine all patients with AHV for hepatitis D in order to exclude underdiagnoses. The more severe course of AHD superinfection, compared with co-infection, requires increased prevention and clinical surveillance of patients with chronic HB.
About the Authors
Kalys A. Nogoibaeva
Kyrgyz State Medical Institute for Retraining and Advanced Training
Russian Federation
Russian Federation
Saparbu T. Tobokalova
Kyrgyz State Medical Institute for Retraining and Advanced Training
Russian Federation
Russian Federation
Svetlana I. Umarova
Kyrgyz State Medical Institute for Retraining and Advanced Training
Russian Federation
Russian Federation
References
1. Patel E. U. Patel E. U., Thio C. L., et al. Prevalence of hepatitis B and hepatitis D virus infections in the United States, 2011-2016. Clin. Infec. Dis. 2019;69:709-712
2. Do A., Reo N. S. Chronic viral hepatitis: current management and future directions. Gеррat Comm. 2020; 4:329-341
3. Vincent T. L., SavianoA., Schuster C., et al. Targeting the Host for New Therapeutic Perspectives in Hepatitis D. J. Clin. Med. 2020;9:1
4. Tobokalova S. T. Acute hepatitis B and D in children with concomitant pathology. diss. Dr. medical Sciences: 14.00.09. Moscow, 2004. (in Russ.) @@Тобокалова С. Т. Острые гепатиты В и D у детей с сопутствующей патологией: автореф. дис. … д-ра мед. наук: 14.00.09 / - Москва, 2004
5. Suranbaeva G. S. Chronic viral hepatitis B, C, D in the Kyrgyz Republic (clinical and therapeutic aspects). diss. Dr. medical Sciences: 14.01.09. Bishkek. 2012. 212 p. (in Russ.) @@Суранбаева Г. С. Хронические вирусные гепатиты B, C, D в Кыргызской Республике (клинические и терапевтические аспекты): дис. д-ра. мед. наук: 14.01.09 / - Бишкек, 2012. - 212 с
6. Anarbaeva Zh. A. Clinical and epidemiological features of chronic viral hepatitis D in the southern region of the Kyrgyz Republic: diss. cand. medical Sciences. 14.01.09. Bishkek. 2017. 120 p. (in Russ.) @@Анарбаева Ж. А. Клинико - эпидемилогические особенности хронического вирусного гепатита D в южном регионе Кыргызской Республики: дис. канд. мед. наук: 14.01.09 /- Бишкек, 2017. - 120 с
7. “Report on the movement of infectious and parasitic diseases”, state reporting form No. 1 of the Department for Disease Prevention and State Sanitary and Epidemiological Surveillance under the Ministry of Health of the Kyrgyz Republic. Available at: https://dgsen.kg/, http://cez.med.kg/ Access: 05.05.2021. @@«Отчет о движении инфекционных и паразитарных заболеваний», государственная отчетная форма № 1 Департамента профилактики заболеваний и государственного санитарно-эпидемиологического надзора при Министерстве здравоохранения Кыргызской Республики. Доступно по https://dgsen.kg/, http://cez.med.kg/
8. Principles of Epidemiology in Public Health Practice. Atlanta, GA 30333, 1998. Available at: https://www.cdc.gov/csels/dsepd/ss1978/ Access: 05.05.2021. @@Ричард Бикер. Принципы эпидемиологии. Введение в практическую эпидемиологию и биостатистику. Атланта: 1998. https://www.cdc.gov/csels/dsepd/ss1978/
9. Nogoibaeva K.A., Tobokalova S. T. Etiological and Epidemiological Characteristics of Lethality from Acute Viral Hepatitis, Kyrgyzstan, 2009-2018. Zhurnal mikrobiologii, epidemiologii i immunobiologii = Journal of microbiology, epidemiology and immunobiology, Russian journal. 2020; 97(1): 40-46. (In Russ.) doi: 10.36233/0372-9311-2020-97-1-40. @@Ногойбаева К. А., Тобокалова С. Т. Этиологическая и эпидемиологическая характеристика летальности от острого вирусного гепатита в Кыргызстане, 2009-2018 гг. // Журнал микробиологии, эпидемиологии и иммунобиологии. - Москва. -2020. -№ 1. -С.40-46. http://elibrary.ru/item.asp?id=42457674
10. Zairova G.M., Tobokalova S. T., Nogoibaeva K. A., et al. Epidemiological features of familial foci of hepatitis B, C and D. VESTNIK of KSMA named after I.K. AKHUNBAEV. 2015;(4):135-139. (in Russ.) @@Заирова Г.М, Тобокалова С. Т., Ногойбаева К. А., и др. Эпидемиологические особенности семейных очагов гепатита В, С и D // Вестник КГМА. - 2015. - № 4. - С. 135-139
11. Nurmatov Z. Sh. Evaluation of the effectiveness of vaccination of newborns against hepatitis B in Bishkek and Jalalabat, Kyrgyzstan, 2005. Medicine of Kyrgyzstan. 2007;(3):175-181. (in Russ.) @@Нурматов З. Ш. Оценка эффективности вакцинопрофилактики новорожденных против гепатита Ввг. Бишкек и г. Жалалабат, Кыргызстан, 2005 г. //Медицина Кыргызстана. - 2007. - № 3. - С. 175-181
12. Theamboonlers A. Hansurabhanon T., Verachai V., et al. Hepatitis D virus infection in Thailand: HDV genotyping by RT - PCR, RFLP and direct sequencing. Infection. 2002;71:140-144
13. Nisini R., Nisini R., Paroli M., et al. Human CD4+ T-cell response to hepatitis delta virus: identification of multiple epitopes and characterization of T-helper cytokine profiles. J. Virol. 1997;71: 2241-2251
14. Roitberg G.E., Strutynsky A. B.Internal diseases. Liver, biliary tract, pancreas: textbook. Moscow. MEDpress-inform Publ., 2013. 632 P. @@Ройтберг Г. Е., Струтынский А. В. Внутренние болезни. Печень, желчевыводящие пути, поджелудочная железа: учебное пособие - М.: МЕДпресс-информ, 2013. - С. 632
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For citations:
Nogoibaeva K.A., Tobokalova S.T., Umarova S.I. Clinical and Epidemiological Characteristics of Acute Hepatitis B with Delta agent in Kyrgyzstan, 1999-2018. Experimental and Clinical Gastroenterology. 2022;(7):81-89. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-203-7-81-89
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