New approach to the treatment of cancer of large duodenal papilla and extrahepatic bile ducts with photodynamic therapy
https://doi.org/10.31146/1682-8658-ecg-201-5-78-85
Abstract
The study is based on the treatment of 79 patients with adenocarcinoma of large duodenal papilla and extrahepatic bile ducts. 29 patients received palliative bile drainage operations with PDT. 50 patients in the group of chronological control only palliative bile drainage operations had been performed. Patients in research group received from 1 to 3 PDT courses in a year. In total 29 patients received 52 PDT courses. Outcomes were assessed by determining the median survival.
The treatment was well-tolerated by the patients. The median survival time was 18 months (11–60 months). In patients who had only one PDT session during the year median survival was 12,5 months; in patients who had two or more PDT sessions median survival was 29 months (15–60 months).
Results of PDT treatment for cancer of this localization are comparable with the results of radical surgeries and overcome palliative surgeries. Decrease of tumor growth rate and longer survival period in patients after PDT are determined by vascular mechanisms produced by PDT (vascular thrombosis and impaired tumor blood supply), these factors provide long-term process stabilization. Repeated PDT courses signifi cantly improve treatment results.
About the Authors
E. P. Stranadko
Skobelkin State Scientific Center of Laser Medicine
Russian Federation
Russian Federation
Eugeniy F. Stranadko, MD, Dг. Sci. (med), professor, head of department of laser oncology and photodynamic therapy
121165, Moscow, Studencheskaya str., Build. 40
A. V. Baranov
Skobelkin State Scientific Center of Laser Medicine
Russian Federation
Russian Federation
Alexey V. Baranov, MD, Dг. Sci. (med), professor, director
121165, Moscow, Studencheskaya str., Build. 40
V. A. Duvansky
Skobelkin State Scientific Center of Laser Medicine
Russian Federation
Russian Federation
Vladimir A. Duvansky, MD, Dг. Sci. (med), professor, head of department of endoscopic surgery
121165, Moscow, Studencheskaya str., Build. 40
A. I. Lobakov
Moscow Regional Research and Clinical Institute “MONIKI”
Russian Federation
Russian Federation
Alexandre I. Lobakov, MD, Dг. Sci. (med), professor
129110, Moscow, Schepkina str., Build. 61/2, 15
V. A. Morokhotov
Moscow Regional Research and Clinical Institute “MONIKI”
Russian Federation
Russian Federation
Vladimir A. Morokhotov, MD, surgeon
129110, Moscow, Schepkina str., Build. 61/2, 15
M. V. Riabov
Skobelkin State Scientific Center of Laser Medicine
Russian Federation
Russian Federation
Mikhail V. Riabov, MD, PhD, senior researcher, department of laser oncology and photodynamic therapy
121165, Moscow, Studencheskaya str., Build. 40
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Review
For citations:
Stranadko E.P., Baranov A.V., Duvansky V.A., Lobakov A.I., Morokhotov V.A., Riabov M.V. New approach to the treatment of cancer of large duodenal papilla and extrahepatic bile ducts with photodynamic therapy. Experimental and Clinical Gastroenterology. 2022;(5):78-85. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-201-5-78-85
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