Preview

Experimental and Clinical Gastroenterology

Advanced search

Antimicrobial effect of nitric oxide

https://doi.org/10.31146/1682-8658-ecg-201-5-59-63

Abstract

138 patients who were diagnosed with gastric and duodenal ulcers during EGDS were treated. The inclusion of exogenous nitric oxide in the anti-ulcer treatment of patients contributed to the eradication of Hp, restoration of the membrane component of damaged cells, stabilization of local immune reactions and humoral immunity. NO-therapy accelerated the epithelialization of ulcers by 2 times compared to patients who did not receive nitric oxide in complex therapy.

About the Authors

N. E. Сhernekhovskaya
Russian Medical Academy of Continuing Professional Education
Russian Federation

Natalia E. Chernekhovskaya, MD, Professor of the Department of Endoscopy

125993, Moscow, st. Barrikadnaya, 2/1, build. 1



A. F. Eryashev
“3 Central Military Hospital named after A. A. Vishnevsky” of the Ministry of Defense of the Russian Federation
Russian Federation

Alexander F. Eryashev, doctor of the 5th Department of abdominal Surgery

143420, Moscow region, city district Krasnogorsk, vill. Novy, build.1



A. V. Povalyaev
Russian Medical Academy of Continuing Professional Education
Russian Federation

Alexey V. Povalyaev, MD, Associate Professor of the Department of Endoscopy

125993, Moscow, st. Barrikadnaya, 2/1, build. 1



A. V. Pekshev
Moscow State Technical University named after N. E. Bauman (National Research University
Russian Federation

Alexander V. Pekshev, head of laboratory

105005, Moscow, 2nd Baumanskaya st., build. 5/1



References

1. Vanin A.F. [NO-therapy: theoretical aspects, clinical experience and problems of using exogenous nitric oxide in medicine. Materials of the scientifi c and practical conference December 4–5, 2001]. Moscow. 2001. 190 p. (in Russ.)

2. Bian K., Murad F. Nitric oxide (NO)—biogeneration, regulation, and relevance to human diseases. Front Biosci. 2003;8: d264-d278. Published 2003 Jan 1. doi:10.2741/997

3. Severin E.S., Muizhnek E. L., Severin S. E. [The concept of secondary messengers: from fundamentals to clinical practice]. Moscow. Dimitrea Graph Group Publ., 2005. 336 p. (in Russ.)

4. Tack J., Demedts I., Meulemans A., Schuurkes J., Janssens J. Role of nitric oxide in the gastric accommodation reflex and in meal induced satiety in humans. Gut. 2002;51(2):219–224. doi:10.1136/gut.51.2.219

5. Takeuchi K., Kagawa S., Mimaki H., Aoi M., Kawauchi S. COX and NOS isoforms involved in acid-induced duodenal bicarbonate secretion in rats. Dig Dis Sci. 2002;47(9):2116–2124. doi:10.1023/a:1019601702559

6. Arzamassev A.P., Severina I. S., Grigoriev N. B., Granik V. G. Exogenous donors of nitric oxide and inhibitors of NO-synthesis (chemical aspects). Annals of the Russian Academy of Medical Sciences. 2003;(12):88–95. (in Russ.)

7. Pal’tsev M.A., Ivanov A. A., Severin S. E. [Intercellular interactions]. Moscow. Medicine Publ., 2003. 288 p. (in Russ.)

8. Pokrovsky V.I., Vinogradov N. A. [Nitric oxide, its physiological and pathophysiological properties]. Terapevticheskii arkhiv. 2005;77(1):82–85. (in Russ.)

9. Granik V.G., Grigoriev N. B. [Nitric oxide (NO)]. Moscow. University Book Publ., 2004. 359 p. (in Russ.)

10. Golikov P.P. [Nitric oxide in the clinic of urgent diseases]. Moscow. MEDPRAKTIKA-M. Publ., 2004. 179 p. (in Russ)

11. Chernekhovskaya N.E., Shishlo V. K., Chomaeva A. A. [Endothelium of blood and lymphatic vessels]. Moscow. Institute of Animal Husbandry Publ., 2010. 182 p. (in Russ.)

12. Vinogradov N. A. Antimicrobial properties of nitrogen oxide and regulation of its biosynthesis in macroorganism. Antibiotic. and chemother. 1998;43(2):24–29. (in Russ)

13. Alam M.S., Akaike T., Okamoto S., et al. Role of nitric oxide in host defense in murine salmonellosis as a function of its antibacterial and antiapoptotic activities. Infect Immun. 2002;70(6):3130–3142. doi:10.1128/IAI.70.6.3130–3142.2002

14. Ignarro LJ. Physiology and pathophysiology of nitric oxide. Kidney Int Suppl. 1996;55: S2-S5. PMID:8743501.

15. Vyrenkov Yu.E., Esipov A. V., Musailov V. A., et al. The application of nitrogen oxide. Russian Journal of Physiotherapy, Balneology and Rehabilitation. 2014;(1): 33–40. (in Russ.)

16. Pekshev A.V., Kozlov N. P., Vagapov A. B., et al. [The Plason apparatus – principles of formation of air-plasma and NO-containing gas flows]. Conference [NO-therapy: theoretical aspects, clinical experience and problems of the application of exogenous nitric oxide in medicine]. Moscow. 2001, pp. 60–63. (in Russ.)

17. Aruin L. I., Kapuller L. L., Isakov V. A. [Morphologic diagnosis of diseases of the stomach and intestines]. Moscow. Triada-Kh. Publ., 1998. 496 p. (in Russ.)


Review

For citations:


Сhernekhovskaya N.E., Eryashev A.F., Povalyaev A.V., Pekshev A.V. Antimicrobial effect of nitric oxide. Experimental and Clinical Gastroenterology. 2022;(5):59-63. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-201-5-59-63

Views: 296


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1682-8658 (Print)