Functional state of the glands of the gastric mucosa in chronic Hp-associated gastritis in children
https://doi.org/10.31146/1682-8658-ecg-201-5-23-26
Abstract
Introduction. Studies of the gastric mucosa using biomarkers of its functional state in children are isolated, and there is also no normative base for their assessment.
The aim of the work was to establish the reference values of the levels of gastrin-17, pepsinogens I and II in the blood serum of children and the nature of their changes in chronic Hp-associated gastritis.
Material and methods. 112 children aged 7–15 years with chronic gastritis associated with Hp were examined. The examination program included esophagogastroduodenoscopy, morphological examination of gastrobioptates and determination of serum concentrations of gastrin-17, pepsinogens I and II, class G antibodies to Hp.
Results. A regulatory framework has been developed to assess serum concentrations of gastrin and pepsinogens in childhood. It was found that as infl ammation progresses in chronic Hp-associated gastritis in children, an increase in the level of biomarkers, as well as the titer of class G antibodies to Hp, is observed. Changes in the content of biomarkers in the blood serum of children are uninformative in relation to the diagnosis of atrophic gastritis.
Conclusion. These studies of serum levels of gastrin-17, I and II and class G antibodies to Hp pepsinogens can be used as an additional non-morphological criterions for the severity of the infl ammatory process in the gastric mucosa during dynamic monitoring of children with chronic gastritis.
About the Authors
E. M. Spivak
Yaroslavl State Medical University
Russian Federation
Russian Federation
Evgeny M. Spivak, MD, professor of Pediatric department № 1
150000, Yaroslavl, Revolutionary Str., build. 5
A. I. Khavkin
Scientific Research Clinical Institution of Childhood of the Ministry of Health of the Moscow Region; Belgorod State Research University
Russian Federation
Russian Federation
Anatoly I. Khavkin, MD, PhD, Dr Sci, Professor, Head of the Moscow Regional Center for Pediatric Gastroenterology, Hepatology and Abdominal Surgery; Professor of the Department of Pediatrics with a course of pediatric surgical diseases at the Medical Institute
115093, Moscow, str. Bolshaya Serpukhovskaya, build. 62
308015, Belgorod region, Belgorod, st. Pobedy, build.85
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Review
For citations:
Spivak E.M., Khavkin A.I. Functional state of the glands of the gastric mucosa in chronic Hp-associated gastritis in children. Experimental and Clinical Gastroenterology. 2022;(5):23-26. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-201-5-23-26
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