Probiotic strain Bifidobacterium longum BB536 - a nutraceutical of a wide profile
https://doi.org/10.31146/1682-8658-ecg-198-2-77-85
Abstract
Bifidobacterium B.longum BB536 is a safe multifunctional probiotic with proven clinical efficacy. By modulating the composition of the intestinal microbiome, the BB536 strain exhibits anti-inflammatory, antiallergic, antiviral, antibacterial, fungicidal properties, shown in experimental and clinical studies. The effectiveness of the use of strain BB536 in the treatment of intestinal pathology (for stool normalization, in the treatment of ulcerative colitis, irritable bowel syndrome, etc.), as well as for normalizing the lipid profile of blood and fat metabolism, has been shown.
About the Authors
O. A. Gromova
Federal Research Center “Informatics and Control” RAS (FRC IU RAS)
Russian Federation
Russian Federation
I. Yu. Torshin
Federal Research Center “Informatics and Control” RAS (FRC IU RAS)
Russian Federation
Russian Federation
References
1. O.A., Torshin I. Yu., Tetruashvili N. K., Serov V. N. Systematic analysis of the clinical efficacy of the strain-specific effects of probiotics with docosahexaenoic acid for use during pregnancy and lactation. Questions of gynecology, obstetrics and perinatology. 2019; 18 (3): 52-63. (in Russ.) doi: 10.20953/1726-1678-2019-3-52-63@@ Громова О. А., Торшин И. Ю., Тетруашвили Н. К., Серов В. Н. Систематический анализ клинической эффективности штамм-специфичных эффектов пробиотиков с докозагексаеновой кислотой для использования во время беременности и кормления. Вопросы гинекологии, акушерства и перинатологии. 2019; 18(3): 52-63. doi: 10.20953/1726-1678-2019-3-52-63.
2. Torshin I. Yu., Gromova O. A., Maksimov V. A., Zakharova I. N., Malyavskaya S. I. Analysis of the strain-specific effects of L. casei DG lactobacilli (L. paracasei CNCM I-1572) and the possibility of their application in clinical practice. Experimental and clinical gastroenterology. 2019; 162 (2): 151-158. (in Russ.) doi: 10.31146/1682-8658-ecg-162-2-151-158@@ Торшин И. Ю., Громова О. А., Максимов В. А., Захарова И. Н., Малявская С. И. Анализ штамм-специфичных эффектов лактобацилл L. casei DG (L. paracasei CNCM I-1572) и возможность их применения в клинической практике. Экспериментальная и клиническая гастроэнтерология. 2019;162(2): 151-158. doi: 10.31146/1682-8658-ecg-162-2-151-158
3. Wong C., Odamaki T., Xiao J. Beneficial effects of Bifidobacterium longum subsp. longum BB536 on human health. Journal of Functional Foods. 2019, 54:506-519.
4. Abe F., Muto M., Yaeshima T., et al. Safety evaluation of probiotic bifidobacteria by analysis of mucin degradation activity and translocation ability. Anaerobe. 2010;16(2), 131-136. doi: 10.1016/j.anaerobe.2009.07.006.
5. Grill J., Schneider F., Crociani J., Ballongue J. Purification and Characterization of Conjugated Bile Salt Hydrolase from Bifidobacterium longum BB536. Appl Environ Microbiol. 1995 Jul;61(7):2577-82. doi: 10.1128/aem.61.7.2577-2582.1995. PMID: 16535071
6. Falony G., Vlachou A., Verbrugghe K., De Vuyst L. Cross-feeding between Bifidobacterium longum BB536 and acetate-converting, butyrate-producing colon bacteria during growth on oligofructose. Appl Environ Microbiol. 2006 Dec;72(12):7835-41. doi: 10.1128/AEM.01296-06
7. Sugahara H., Odamaki T., Fukuda S., Kato T., Xiao J. Z., Abe F., Kikuchi J., Ohno H. Probiotic Bifidobacterium longum alters gut luminal metabolism through modification of the gut microbial community. Sci Rep. 2015 Aug 28;5:13548. doi: 10.1038/srep13548
8. Wu B. B., Yang Y., Xu X., Wang W. P. Effects of Bifidobacterium supplementation on intestinal microbiota composition and the immune response in healthy infants. World J Pediatr. 2016 May;12(2):177-82. doi: 10.1007/s12519-015-0025-3
9. Toscano M., De Grandi R., Stronati L, De Vecchi E., Drago L. Effect of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 on the healthy gut microbiota composition at phyla and species level: A preliminary study. World J Gastroenterol. 2017 Apr 21;23(15):2696-2704. doi: 10.3748/wjg.v23.i15.2696
10. Odamaki T., Sugahara H., Yonezawa S., et al. Effect of the oral intake of yogurt containing Bifidobacterium longum BB536 on the cell numbers of enterotoxigenic Bacteroides fragilis in microbiota. Anaerobe. 2012 Feb;18(1):14-8. doi: 10.1016/j.anaerobe.2011.11.004
11. Iwabuchi N., Takahashi N., Xiao J. Z., Yonezawa S., Yaeshima T., Iwatsuki K., Hachimura S. Suppressive effects of Bifidobacterium longum on the production of Th2-attracting chemokines induced with T cell-antigen-presenting cell interactions. FEMS Immunol Med Microbiol. 2009 Apr;55(3):324-34. doi: 10.1111/j.1574-695X.2008.00510.x
12. Mizuta M., Endo I., Yamamoto S., Inokawa H., et al. Perioperative supplementation with bifidobacteria improves postoperative nutritional recovery, inflammatory response, and fecal microbiota in patients undergoing colorectal surgery: a prospective, randomized clinical trial. Biosci Microbiota Food Health. 2016;35(2):77-87. doi: 10.12938/bmfh.2015-017
13. Xiao J. Z., Kondo S., Yanagisawa N., Miyaji K., Enomoto K., Sakoda T., Iwatsuki K., Enomoto T. Clinical efficacy of probiotic Bifidobacterium longum for the treatment of symptoms of Japanese cedar pollen allergy in subjects evaluated in an environmental exposure unit. Allergol Int. 2007 Mar;56(1):67-75. doi: 10.2332/allergolint.O-06-455
14. Enomoto T., Sowa M., Nishimori K., Shimazu S., et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota.Allergol Int. 2014 Dec;63(4):575-85. doi: 10.2332/allergolint.13-OA-0683
15. Gromova O. A., Torshin I. Yu., Chuchalin A. G., Maksimov V. A. Microbiome, probiotics and COVID-19: promising approaches to support the systems of innate and acquired immunity. Experimental and clinical gastroenterology. 2021; 188 (4): 66-73. (in Russ.) doi: 10.31146/1682-8658-ecg-188-4-66-73@@ Громова О. А., Торшин И. Ю., Чучалин А. Г., Максимов В. А. Микробиом, пробиотики и COVID-19: перспективные подходы к поддержке систем врожденного и приобретённого иммунитета. Экспериментальная и клиническая гастроэнтерология. 2021;188(4): 66-73. doi: 10.31146/1682-8658-ecg-188-4-66-73
16. Iwabuchi N., Xiao J. Z., Yaeshima T., Iwatsuki K. Oral administration of Bifidobacterium longum ameliorates influenza virus infection in mice. Biol Pharm Bull. 2011;34(8):1352-5. doi: 10.1248/bpb.34.1352
17. Lau A. S., Yanagisawa N., Hor Y. Y., Lew L. C., et al. Bifidobacterium longum BB536 alleviated upper respiratory illnesses and modulated gut microbiota profiles in Malaysian pre-school children. Benef Microbes. 2018 Jan 29;9(1):61-70. doi: 10.3920/BM2017.0063
18. Namba K., Hatano M., Yaeshima T., Takase M., Suzuki K. Effects of Bifidobacterium longum BB536 administration on influenza infection, influenza vaccine antibody titer, and cell-mediated immunity in the elderly. Biosci Biotechnol Biochem. 2010;74(5):939-45. doi: 10.1271/bbb.90749
19. Matsumoto T., Ishikawa H., Tateda K., Yaeshima T., Ishibashi N., Yamaguchi K. Oral administration of Bifidobacterium longum prevents gut-derived Pseudomonas aeruginosa sepsis in mice. J Appl Microbiol. 2008 Mar;104(3):672-80. doi: 10.1111/j.1365-2672.2007.03593.x
20. Tomoda T., Nakano Y., Kageyama T.Intestinal Candida overgrowth and Candida infection in patients with leukemia: Effect of Bifidobacterium administration. Bifidobacteria and Microflora. 1988;7(2), 71-74. doi: 10.12938/bifidus1982.7.2_71
21. Inturri R., Trovato L., Volti G. L., Oliveri S., Blandino G. In vitro inhibitory activity of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 alone or in combination against bacterial and Candida reference strains and clinical isolates. Heliyon. 2019 Nov 22;5(11): e02891. doi: 10.1016/j.heliyon.2019.e02891
22. Kageyama T., Tomoda T., Nakano, Y. The effect of Bifidobacterium administration in patients with leukemia. Bifidobacteria and Microflora, 1984;3(1), 29-33. doi: 10.12938/bifidus1982.3.1_29
23. Chitapanarux T., Thongsawat S., Pisespongsa P., Leerapun A., Kijdamrongthum P. Effect of Bifidobacterium longum on PPI-based triple therapy for eradication of Helicobacter pylori: A randomized, double-blind placebo-controlled study. Journal of Functional Foods, 2015;13, 289-294. doi: 10.1016/j.jff.2015.01.003.
24. Fornai M., Pellegrini C., Benvenuti L., et al. Protective effects of the combination Bifidobacterium longum plus lactoferrin against NSAID-induced enteropathy. Nutrition. 2020 Feb;70:110583. doi: 10.1016/j.nut.2019.110583
25. Vitellio P., Celano G., Bonfrate L., Gobbetti M., Portincasa P., De Angelis M. Effects of Bifidobacterium longum and Lactobacillus rhamnosus on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019 Apr 19;11(4):886. doi: 10.3390/nu11040886
26. Bonfrate L., Di Palo D. M., Celano G., Albert A., Vitellio P., De Angelis M., Gobbetti M., Portincasa P. Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients. Eur J Clin Invest. 2020 Mar;50(3): e13201. doi: 10.1111/eci.13201
27. Chen J. C., Lee W. J., Tsou J. J., Liu T. P., Tsai P. L. Effect of probiotics on postoperative quality of gastric bypass surgeries: a prospective randomized trial. Surg Obes Relat Dis. 2016 Jan;12(1):57-61. doi: 10.1016/j.soard.2015.07.010
28. Ohara T., Suzutani T.Intake of Bifidobacterium longum and Fructo-oligosaccharides prevents Colorectal Carcinogenesis. Euroasian J Hepatogastroenterol. 2018 Jan-Jun;8(1):11-17. doi: 10.5005/jp-journals-10018-1251
29. Mustafa S. E., Mustafa S., Ismail A., et al. Impact of prebiotics on equol production from soymilk isoflavones by two Bifidobacterium species. Heliyon. 2020 Oct 23;6(10): e05298. doi: 10.1016/j.heliyon.2020.e05298
30. Al-Sheraji S.H., Amin I., Azlan A., Manap M. Y., Hassan F. A. Effects of Bifidobacterium longum BB536 on lipid profile and histopathological changes in hypercholesterolaemic rats. Benef Microbes. 2015;6(5):661-8. doi: 10.3920/BM2014.0032
31. Al-Sheraji S.H., Ismail A., Manap M. Y., Mustafa S., Yusof R. M., Hassan F. A. Hypocholesterolaemic effect of yoghurt containing Bifidobacterium pseudocatenulatum G4 or Bifidobacterium longum BB536. Food Chem. 2012 Nov 15;135(2):356-61. doi: 10.1016/j.foodchem.2012.04.120
32. El-Zahar K.M., Hassan M. F.Y., Al-Qaba S. F. Protective Effect of Fermented Camel Milk Containing Bifidobacterium longum BB536 on Blood Lipid Profile in Hypercholesterolemic Rats. J Nutr Metab. 2021 Oct 29;2021:1557945. doi: 10.1155/2021/1557945
33. Pellegrini M., Ippolito M., Monge T., et al. Gut microbiota composition after diet and probiotics in overweight breast cancer survivors: a randomized open-label pilot intervention trial. Nutrition. 2020 Jun;74:110749. doi: 10.1016/j.nut.2020.110749
34. Inoue T., Kobayashi Y., Mori N., Sakagawa M., Xiao J. Z., Moritani T., Sakane N., Nagai N. Effect of combined bifidobacteria supplementation and resistance training on cognitive function, body composition and bowel habits of healthy elderly subjects. Benef Microbes. 2018 Dec 7;9(6):843-853. doi: 10.3920/BM2017.0193
35. Torshin I. Yu., Gromova O. A. Alternative approaches to correcting hypercholesterolemia: the effects of standardized red rice extracts and its synergists. General Medicine. 2021;(1):89-98. (in Russ.) doi: 10.24412/2071-5315-2021-12283@@ Торшин И. Ю., Громова О. А. Альтернативные подходы к коррекции гиперхолестеринемии: эффекты стандартизированных экстрактов красного риса и его синергистов. Лечебное дело, № 1, 2021, с. 89-98, doi: 10.24412/2071-5315-2021-12283
36. Cicolari S., Pavanello C., Olmastroni E., et al.Interactions of Oxysterols with Atherosclerosis Biomarkers in Subjects with Moderate Hypercholesterolemia and Effects of a Nutraceutical Combination (Bifidobacterium longum BB536, Red Yeast Rice Extract) (Randomized, Double-Blind, Placebo-Controlled Study). Nutrients. 2021 Jan 28;13(2):427. doi: 10.3390/nu13020427
37. Ruscica M., Pavanello C., Gandini S., et al. Nutraceutical approach for the management of cardiovascular risk - a combination containing the probiotic Bifidobacterium longum BB536 and red yeast rice extract: results from a randomized, double-blind, placebo-controlled study. Nutr J. 2019 Feb 22;18(1):13. doi: 10.1186/s12937-019-0438-2
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For citations:
Gromova O.A., Torshin I.Yu. Probiotic strain Bifidobacterium longum BB536 - a nutraceutical of a wide profile. Experimental and Clinical Gastroenterology. 2022;(2):77-85. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-198-2-77-85
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