Gastrointestinal manifestations of food allergy in children: oral allergic syndrome
https://doi.org/10.31146/1682-8658-ecg-197-1-120-129
Abstract
Oral allergic syndrome is a manifestation of an acute allergic reaction from the mucous membrane of the oropharynx in the form, itching and tingling on the oral mucosa, dysphonia, itching in the auricles, some patients may experience classic manifestations of hay fever in the form of rhinoconjunctival syndrome. Diagnostics of this disease includes collection of allergic anamnesis, allergy examination. The only pathogenetic method of therapy is carrying out specific immunotherapy with causally significant allergens.
About the Authors
I. M. Gaiduk
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
I. V. Koltuntseva
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
V. P. Novikova
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
M. O. Revnova
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
E. Yu. Lapina
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
A. I. Khavkin
Research Clinical Institute of Childhood of the Moscow Region; Belgorod State Research University
Russian Federation
Russian Federation
References
1. Namazova-Baranova L. S. Allergies in children: from theory to practice. Moscow. Union of Pediatricians of Russia Publ. 2010-2011. 668 P. (in Russ.)@@ Намазова-Баранова Л. С. Аллергия у детей: от теории к практике. М.: Союз педиатров России. 2010-2011. 668 с.
2. Muraro A., Werfel T., Hoffmann-Sommergruber K., et al. EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. Allergy. 2014;69(8):1008-1025. doi:10.1111/all.12429
3. Baranov A.A., Namazova-Baranova L.S., Borovik T. E., Makarova S. G., et al. Food allergy. Diseases of childhood from A to Z. Moscow. Pediatr Publ., 2013. (in Russ.)@@ Баранов А. А., Намазова-Баранова Л.С., Боровик Т. Э., Макарова С. Г., и соавт. Под редакцией: Баранова А. А., Намазовой-Барановой Л.С., Боровик Т. Э., Макаровой С. Г. Пищевая аллергия. М.: Педиатръ, 2013. Сер. Болезни детского возраста от А до Я.
4. Clinical guidelines “Food Allergy”. 2018, 50 p. (in Russ.)@@ Клинические рекомендации «Пищевая аллергия», 2018, 50 с.
5. Matalygina O. A. This multifaceted allergy. Preschool pedagogy. 2015; 7: 4-10. (in Russ.)@@ Маталыгина О. А. Эта многоликая аллергия, Дошкольная педагогика. 2015; 7: 4-10.
6. Zamyatina Yu.E., Novikova V. P., Melnikova I. Yu. Atopic dermatitis and diseases of the gastrointestinal tract. Medicine: theory and practice. 2020; 5. (1): 40-49. (in Russ.)@@ Замятина Ю. Е., Новикова В. П., Мельникова И. Ю. Атопический дерматит и заболевания желудочно-кишечного тракта. Медицина: теория и практика. 2020; 5. (1): 40-49.
7. Gurina O.P., Blinov A. E., Varlamova O. N., Dementyeva E. A., Stepanova A. A., Blinov G. A. Immunity and atopy. Features in children. Medicine: theory and practice. 2019; 4 (1): 233-240. (in Russ.)@@ Гурина О. П., Блинов А. Е., Варламова О. Н., Дементьева Е. А., Степанова А. А., Блинов Г. А. Иммунитет и атопия. Особенности у детей. Медицина: теория и практика. 2019; 4 (1): 233-240.
8. Nasidze I., Li J., Quinque D., Tang K., Stoneking M. Global diversity in the human salivary microbiome. Genome Res. 2009;19(4):636-643. doi:10.1101/gr.084616.108
9. Nowak-Wegrzyn A., Muraro A. Food protein-induced enterocolitis syndrome. Curr Opin Allergy Clin Immunol. 2009;9(4):371-377. doi:10.1097/ACI.0b013e32832d6315
10. Breiteneder H., Ebner C. Molecular and biochemical classification of plant-derived food allergens. J Allergy Clin Immunol. 2000;106(1 Pt 1):27-36. doi:10.1067/mai.2000.106929
11. Tuft L., Blumstein G. I. Studies in food allergy: II. Sensitization to fresh fruits: clinical and experimental observations. J Allergy. 1942; 13(6):574-82.
12. Amlot P.L., Kemeny D. M., Zachary C., Parkes P., Lessof M. H. Oral allergy syndrome (OAS): symptoms of IgE-mediated hypersensitivity to foods. Clin Allergy. 1987;17(1):33-42. doi:10.1111/j.1365-2222.1987.tb02317.x
13. Ortolani C, Ispano M, Pastorello E, Bigi A, Ansaloni R. The oral allergy syndrome. Ann Allergy. 1988;61(6 Pt 2):47-52.
14. Pastorello E.A., Ortolani C., Farioli L., et al. Allergenic cross-reactivity among peach, apricot, plum, and cherry in patients with oral allergy syndrome: an in vivo and in vitro study. J Allergy Clin Immunol. 1994;94(4):699-707. doi:10.1016/0091-6749(94)90177-5
15. Tuano K.T.S., Davis C. M. Oral allergy syndrome in shrimp and house dust mite allergies. J Allergy Clin Immunol Pract. 2018;6(6):2163-2164. doi:10.1016/j.jaip.2018.04.035
16. Valenta R., Kraft D. Type 1 allergic reactions to plant-derived food: a consequence of primary sensitization to pollen allergens. J Allergy Clin Immunol. 1996;97(4):893-895. doi:10.1016/s0091-6749(96)80062-5
17. Webber C.M., England R. W. Oral allergy syndrome: a clinical, diagnostic, and therapeutic challenge. Ann Allergy Asthma Immunol. 2010;104(2):101-117. doi:10.1016/j.anai.2009.11.007
18. Bedolla-Barajas M., Kestler-Gramajo A., Alcalá-Padilla G., Morales-Romero J. Prevalence of oral allergy syndrome in children with allergic diseases. Allergol Immunopathol (Madr). 2017;45(2):127-133. doi:10.1016/j.aller.2016.04.017
19. Chang Y., Kim J., Song W., et al. Oral allergy syndrome in birch pollen sensitized patients in Korea: results of a retrospectice chart review. J Allergy Clin Immunol. 2018; 141(2): AB63. doi: 10.1016/j.jaci.2017.12.202
20. Cascone N., Shankar T., Petrov A., Fajt M. Seasonal allergies, how they relate to oral allergy syndrome (OAS). J Allergy Clin Immunol. 2016; 137(2):83. doi:10.1016/j.jaci.2015.12.400
21. Letner D., Farris A., Khalili H., Garber J. Pollen-food allergy syndrome is a common allergic comorbidity in adults with eosinophilic esophagitis. Dis Esophagus. 2018;31(2):10.1093/dote/dox122. doi:10.1093/dote/dox122
22. Leigh L.Y., Spergel J. M. An in-depth characterization of a large cohort of adult patients with eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2019;122(1):65-72.e1. doi:10.1016/j.anai.2018.09.452
23. Letner D., Farris A., Khalili H., Garber J. Pollen-food allergy syndrome is a common allergic comorbidity in adults with eosinophilic esophagitis. Dis Esophagus. 2018;31(2):10.1093/dote/dox122. doi:10.1093/dote/dox122
24. Azamar-Jácome A., Borjas-Aguilar K., Mendoza-Hernández D. P281 Pollen-food syndrome in a pediatric population attending an allergy clinic in Mexico City. Ann Allergy Asthma Immunol. 2016; 117(5):105. doi: 10.1016/j.anai.2016.09.294
25. Dondi A., Tripodi S., Panetta V., et al. Pollen-induced allergic rhinitis in 1360 Italian children: comorbidities and determinants of severity. Pediatr Allergy Immunol. 2013;24(8):742-751. doi:10.1111/pai.12136
26. Ivković-Jureković I. Oral allergy syndrome in children.Int Dent J. 2015;65(3):164-168. doi:10.1111/idj.12164
27. Bedolla-Barajas M., Morales-Romero J., Ortiz-Miramontes L.R., Jáuregui-Franco R. O. Frequency and clinical features of the oral allergy syndrome in Mexican adults with nasal pollinosis. Rev Alerg Mex. 2013;60(1):17-25.
28. Morfín-Maciel B.M., Flores I., Rosas-Alvarado A., Bautista M., López-López J. R. Sensibilización a pólenes de la familia Oleaceae en un grupo de pacientes de la Ciudad de México [Sensitization to pollens of Oleaceae family in a group of patients from Mexico City]. Rev Alerg Mex. 2009;56(6):198-203.
29. Skypala I.J., Bull S., Deegan K., et al. The prevalence of PFS and prevalence and characteristics of reported food allergy; a survey of UK adults aged 18-75 incorporating a validated PFS diagnostic questionnaire. Clin Exp Allergy. 2013;43(8):928-940. doi:10.1111/cea.12104
30. Movsisyan M., Hakobyan A., Gambarov S. Pollen food allergy syndrome (PFAS) among young Armenian adults. J Allergy Clin Immunol. 2019;143(2):433. doi:10.1016/j.jaci.2018.12.981
31. Reinmuth-Selzle K., Kampf C. J., Lucas K., et al. Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants. Environ Sci Technol. 2017;51(8):4119-4141. doi:10.1021/acs.est.6b04908
32. Bublin M., Kostadinova M., Radauer C., et al. IgE cross-reactivity between the major peanut allergen Ara h 2 and the nonhomologous allergens Ara h 1 and Ara h 3. J Allergy Clin Immunol. 2013;132(1):118-124. doi:10.1016/j.jaci.2013.01.022
33. Mattila P., Joenväärä S., Renkonen J., Toppila-Salmi S., Renkonen R. Allergy as an epithelial barrier disease. Clin Transl Allergy. 2011;1(1):5. Published 2011 Jun 10. doi:10.1186/2045-7022-1-5
34. Steelant B., Farré R., Wawrzyniak P., et al. Impaired barrier function in patients with house dust mite-induced allergic rhinitis is accompanied by decreased occludin and zonula occludens-1 expression. J Allergy Clin Immunol. 2016;137(4):1043-1053.e5. doi:10.1016/j.jaci.2015.10.050
35. Sampson H. A. Food allergy. Part 1: immunopathogenesis and clinical disorders. J Allergy Clin Immunol. 1999;103(5 Pt 1):717-728. doi:10.1016/s0091-6749(99)70411-2
36. D’Amato G., Spieksma F. T., Liccardi G., et al. Pollen-related allergy in Europe. Allergy. 1998;53(6):567-578. doi:10.1111/j.1398-9995.1998.tb03932.x
37. Kondo Y., Urisu A. Oral allergy syndrome. Allergol Int. 2009;58(4):485-491. doi:10.2332/allergolint.09-RAI-0136
38. Wensing M., Akkerdaas J. H., van Leeuwen W. A., et al. IgE to Bet v 1 and profilin: cross-reactivity patterns and clinical relevance. J Allergy Clin Immunol. 2002;110(3):435-442. doi:10.1067/mai.2002.126380
39. Konstantinou G.N., Grattan C. E. Food contact hypersensitivity syndrome: the mucosal contact urticaria paradigm. Clin Exp Dermatol. 2008;33(4):383-389. doi:10.1111/j.1365-2230.2008.02893.x
40. Asakura K., Tamamoto T., Shirasaki H., et al. Evaluation of relationships between foods and pollen antigens in peach oral allergy patients-serous specific IgE levels of peach recombinant Antigen [in Japanese]. Arerugi. 2009; 58(2):133-139.
41. Sancho A.I., Rigby N. M., Zuidmeer L., et al. The effect of thermal processing on the IgE reactivity of the non-specific lipid transfer protein from apple, Mal d 3. Allergy. 2005;60(10):1262-1268. doi:10.1111/j.1398-9995.2005.00876.x
42. Asero R., Antonicelli L., Arena A., et al. Causes of food-induced anaphylaxis in Italian adults: a multi-centre study.Int Arch Allergy Immunol. 2009;150(3):271-277. doi:10.1159/000222679
43. Palacín A., Gómez-Casado C., Rivas L. A., et al. Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. PLoS One. 2012;7(12): e50799. doi:10.1371/journal.pone.0050799
44. Schulten V., Nagl B., Scala E., et al. Pru p 3, the nonspecific lipid transfer protein from peach, dominates the immune response to its homolog in hazelnut. Allergy. 2011;66(8):1005-1013. doi:10.1111/j.1398-9995.2011.02567.x
45. Alessandri C., Ferrara R., Bernardi M. L., et al. Molecular approach to a patient’s tailored diagnosis of the oral allergy syndrome. Clin Transl Allergy. 2020;10:22. Published 2020 Jun 17. doi:10.1186/s13601-020-00329-8
46. Santos A.F., Du Toit G., O’Rourke C., et al. Biomarkers of severity and threshold of allergic reactions during oral peanut challenges. J Allergy Clin Immunol. 2020;146(2):344-355. doi:10.1016/j.jaci.2020.03.035
47. Deng S., Yin J. Clinical utility of basophil activation test in diagnosis and predicting severity of mugwort pollen-related peach allergy. World Allergy Organ J. 2019;12(6):100043. Published 2019 Jun 21. doi:10.1016/j.waojou.2019.100043
48. Offermann L.R., Schlachter C. R., Perdue M. L., et al. Structural, Functional, and Immunological Characterization of Profilin Panallergens Amb a 8, Art v 4, and Bet v 2. J Biol Chem. 2016;291(30):15447-15459. doi:10.1074/jbc.M116.733659
49. Bernardi M.L., Giangrieco I., Camardella L., et al. Allergenic lipid transfer proteins from plant-derived foods do not immunologically and clinically behave homogeneously: the kiwifruit LTP as a model. PLoS One. 2011;6(11): e27856. doi:10.1371/journal.pone.0027856
50. Giangrieco I., Alessandri C., Rafaiani C., et al. Structural features, IgE binding and preliminary clinical findings of the 7kDa Lipid Transfer Protein from tomato seeds. Mol Immunol. 2015;66(2):154-163. doi:10.1016/j.molimm.2015.02.025
51. Ferreira F., Hirtenlehner K., Jilek A., et al. Dissection of immunoglobulin E and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: potential use of hypoallergenic isoforms for immunotherapy. J Exp Med. 1996;183(2):599-609. doi:10.1084/jem.183.2.599
52. Jimenez-Lopez J.C., Rodríguez-García M.I., Alché J. D. Analysis of the effects of polymorphism on pollen profilin structural functionality and the generation of conformational, T- and B-cell epitopes [published correction appears in PLoS One. 2014;9(1). doi:10.1371/annotation/3008c3af-753f-4085-b85e-5ae0c34a7889]. PLoS One. 2013;8(10): e76066. Published 2013 Oct 17. doi:10.1371/journal.pone.0076066
53. Ferreira F., Ebner C., Kramer B., et al. Modulation of IgE reactivity of allergens by site-directed mutagenesis: potential use of hypoallergenic variants for immunotherapy. FASEB J. 1998;12(2):231-242. doi:10.1096/fasebj.12.2.231
54. Reinmuth-Selzle K., Kampf C. J., Lucas K., et al. Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants. Environ Sci Technol. 2017;51(8):4119-4141. doi:10.1021/acs.est.6b04908
55. Chimielewska A., Mazur M., Sacha M., et al. Zespół alergii jamy ustnej u pacjentów z alergia pyłkowa [Oral allergy syndrome in patients with pollen allergy]. Przegl Lek. 2013;70(11):885-887.
56. Ebisawa M., Ito K., Fujisawa T.; Committee for Japanese Pediatric Guideline for Food Allergy, The Japanese Society of Pediatric Allergy and Clinical Immunology; Japanese Society of Allergology. Japanese guidelines for food allergy 2020. Allergol Int. 2020;69(3):370-386. doi:10.1016/j.alit.2020.03.004
57. Yudintseva O.S., Penkov D. G., Ulyanicheva E. S. Oral allergic syndrome. Medicine: theory and practice. 2020; 5 (1): 87-94. (in Russ.)@@ Юдинцева О. С., Пеньков Д. Г., Ульяничева Е. С. Оральный аллергический синдром. Медицина: теория и практика. 2020; 5 (1): 87-94.
58. Elkina T.N., Gribanova O. A., Surovikina E. A., Setskova S. Yu. Pollinosis in children: personification of therapy.Russian Bulletin of Perinatology and Pediatrics. 2018; 63 (4): 156-15. (in Russ.) doi:10.21508/1027-4065-congress-2018@@ Елкина Т. Н., Грибанова О. А., Суровикина Е. А., Сецкова С. Ю., Поллиноз у детей: персонификация терапии, Российский вестник перинаталогии и педиатрии. 2018; 63 (4): 156-15. doi: 10.21508/1027-4065-congress-2018
59. Gaiduk I. M. Respiratory allergy in children: epidemiology. A modern approach to therapy and prevention. 2013. 25 P. (in Russ.)@@ Гайдук И. М. Респираторная аллергия у детей: эпидемиология. Современный подход к терапии и профилактике. Автореферат дисс. док., 2013; 25 с.
60. Sergeev AV, Mokronosova MA, Oral allergy syndrome. Medical immunology. 2011; 13 (1): 17-28. (in Russ.)@@ Сергеев А. В., Мокроносова М. А., Синдром оральной аллергии. Медицинская иммунология. 2011; 13 (1): 17-28.
Review
For citations:
Gaiduk I.M., Koltuntseva I.V., Novikova V.P., Revnova M.O., Lapina E.Yu., Khavkin A.I. Gastrointestinal manifestations of food allergy in children: oral allergic syndrome. Experimental and Clinical Gastroenterology. 2022;(1):120-129. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-197-1-120-129
Views:
440
Email this article 