Chemomicrobiome analysis of the ornithine molecule
https://doi.org/10.31146/1682-8658-ecg-194-10-126-131
Abstract
Hepatoprotectors and prebiotic molecules that promote the growth of intestinal flora differ significantly in their effects on different representatives of the human microbiome. This work presents the results of a comparative chemomicrobiomic analysis of ornithine and reference molecules (S-ademetionine, ursodeoxycholic acid, lactulose, and fructose). For each of the studied molecules, estimates of the values of the area under the growth curve were obtained for a representative sample of human microbiota, which included 38 commensal bacteria (including bifidobacteria and lactobacilli) and the values of the minimum inhibitory concentrations (MIC) for 152 strains of pathogenic bacteria. It has been shown that ornithine, to a lesser extent than the reference molecules, stimulates the growth of pathogenic bacteria of the genera Aspergillus, Klebsiella, Pseudomonas, Staphylococcus and Candida fungi. Ornithine is also less likely to stimulate the growth of more aggressive bacteria (Biosafety Level 2) and to a greater extent less aggressive bacteria (Biosafety Level 1). By stimulating butyric and other short-chain fatty acid-producing microorganisms, ornithine can improve the profile of gut microbiota.
About the Authors
I. Yu. Torshin
Federal Research Center “Informatics and Control” RAS (FRC IU RAS); Northern State Medical University of the Ministry of Health of Russia
Russian Federation
Russian Federation
Ivan Yu. Torshin - PhD in Chemistry, senior research fellow at the Institute of Pharmacoinformatics.
Vavilova st., 44, building 2, Moscow 119333; 163000, Arkhangelsk, Troitsky pr., 51.
O. A. Gromova
Federal Research Center “Informatics and Control” RAS (FRC IU RAS); Northern State Medical University of the Ministry of Health of Russia
Russian Federation
Russian Federation
Olga A. Gromova - MD, PhD, DSc, professor, leading research fellow, research director of the Institute of Pharmacoinformatics.
Vavilova st., 44, building 2, Moscow 119333; 163000, Arkhangelsk, Troitsky pr., 51.
V. A. Maksimov
Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
Valery A. Maksimov - Doctor of Medical Sciences, Professor of the Department of Dietetics and Nutritionology.
Barrikadnaya st., 2, building 1, Moscow 123995.
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Review
For citations:
Torshin I.Yu., Gromova O.A., Maksimov V.A. Chemomicrobiome analysis of the ornithine molecule. Experimental and Clinical Gastroenterology. 2021;(10):126-131. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-194-10-126-131
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