Eradication therapy of helicobacteriosis with probiotics, problems, and prospects
https://doi.org/10.31146/1682-8658-ecg-193-9-60-72
Abstract
Currently, there is an urgent question of optimizing the treatment of stomach diseases associated with Helicobacter pylori, due to the increasing resistance of the pathogen to antibiotics and the presence of side effects of standard therapy. To optimize it, it is proposed to use probiotics as an additional or monotherapy. The review presents the results of studies of anti-helicobacter activity by in vitro and in vivo systems, as well as an assessment of the clinical effectiveness of various probiotic strains of microorganisms in eradication therapy. Several mechanisms of action of probiotics in the treatment of HP-related diseases are discussed. The problems and prospects of using personalized therapy of helicobacteriosis with probiotics and autoprobiotics, based on strains obtained from the gastrointestinal tract, are indicated.
About the Authors
E. I. Ermolenko
Institute of Experimental Medicine
Russian Federation
Russian Federation
Elena I. Ermolenko - PhD, MD (Medicine), Head, Laboratory of Biomedical Microecology; Professor, Faculty of Medical microbiology, Department of Medical Microbiology, , ResearcherID: E-1420–2014, Scopus Author ID: 13004322500.
12, Academic Pavlov street, Saint- Petersburg, 197376r
A. S. Molostova
Institute of Experimental Medicine
Russian Federation
Russian Federation
Anastasiia S. Molostova – Gastroenterologist.
12, Academic Pavlov street, Saint- Petersburg, 197376r
N. S. Gladyshev
Saint Petersburg Pasteur Institute; Saint Petersburg State University
Russian Federation
Russian Federation
Nikita S. Gladyshev - Research Associate, Laboratory of Pathogen Identifi cation; student of the educational program “General Medicine”, Faculty of Medicine.
14, str. Mira, 197101, Saint- Petersburg; 7–9 Universitetskaya Emb., St Petersburg 199034
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Ermolenko E.I., Molostova A.S., Gladyshev N.S. Eradication therapy of helicobacteriosis with probiotics, problems, and prospects. Experimental and Clinical Gastroenterology. 2021;(9):60-72. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-193-9-60-72
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