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Experimental and Clinical Gastroenterology

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Celiac disease and obesity: the possibility of comboridity of pathology in children

https://doi.org/10.31146/1682-8658-ecg-188-4-124-128

Abstract

The article presents an analytical review of scientific research on celiac disease in children in different countries of the world. The prevalence of atypical manifestations of celiac disease has increased over the past two decades. A number of studies in children with celiac disease show that overweight / obesity at the onset of the disease is not uncommon. In addition, there is a tendency to develop overweight / obesity in patients with celiac disease who strictly adhere to a gluten-free diet. It has been shown that among obese children, the prevalence of celiac disease is comparable to the general population frequency. Thus, the diagnosis of celiac disease should be considered even in children with overweight / obesity, when this diagnosis can be easily missed.

About the Authors

V. P. Novikova
St. Petersbur State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation

Valeriya P. Novikova, MD, PhD, DSc, professor, head of the department of introduction to paediatric diseases with the course of baby care, head of the laboratory of medico- social problems in paediatrics

194100, Saint Petersburg, Litovskaya str., g, 2



V. L. Gritsinskaya
St. Petersbur State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation

Vera L. Gritsinskaya, MD, PhD, DSc, leading researcher of the laboratory of medical and social problems in pediatrics

194100, Saint Petersburg, Litovskaya str., g, 2



A. I. Khavkin
N. I. Pirogov Russian National Research Medical University
Russian Federation

Anatoly I. Khavkin, MD, PhD, DSc, professor, head of the department of gastroenterology, Academician Yu. E. Veltishchev Research and Clinical Institute of Pediatrics

125412, Moscow, Taldomskaya str, 2



References

1. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease. J Pediatr Gastroenterol Nutr., 2012 Jan; 54 (1): 136–60. doi: 10.1097/MPG.0b013e31821a23d0

2. Petrarca L., Nenna R. Coeliac Disease and Obesity in Children. J Pediatr Gastroenterol Nutr. 2015 Jul; 61 (1): e4. doi: 10.1097/MPG.0000000000000824

3. Klimov L. Ia., Stoian M. V., Kur’ianinova V.A. et. al. Anthropometric measures of children in the period of clinical manifestation of celiac disease. Eksp Klin Gastroenterol, 2013, 1:55–59. (In Russ.) PMID: 23951900.

4. Bavykina A. B., Zvyagin A. A., Nastausheva T. L., Gusev KYU. et al. Th e state of physical development in children with gluten intolerance. .Applied information aspects of medicine 2017; 20(3): 159–164. (In Russ.)

5. Sorokman T. V., Popelyuk N. O., Kolesnik D. I., Sokolnyk І. S. Indicators of physical development of children with celiac disease. Child health, 2020; 15 (1): 1–5. doi: 10.22141/2224–0551.15.1.2020.196750

6. van der Pals M, Myléus A, Norström F, Hammarroth S., et al. Body mass index is not a reliable tool in predicting celiac disease in children. BMC Pediatr. 2014 Jun 30;14:165. doi: 10.1186/1471–2431–14–165

7. Brambilla P, Picca M, Dilillo D, Meneghin F., et al. Changes of body mass index in celiac children on a gluten-free diet. Metab Cardiovasc Dis. 2013 Mar;23(3):177– 82. doi: 10.1016/j.numecd.2011.10.002

8. Nenna R, Mosca A, Mennini M, Papa RE., et al. Coeliac disease screening among a large cohort of overweight/ obese children. J Pediatr Gastroenterol Nutr. 2015 Mar;60(3):405–7. doi: 10.1097/MPG.0000000000000656

9. Shahraki T, Shahraki M, Hill ID. Frequency of overweight /obesity among a group of children with celiac disease in Iran. Prz Gastroenterol. 2018;13(2):127–131. doi: 10.5114/pg.2018.73347

10. Singh I, Agnihotri A, Sharma A, Verma AK., et al. Patients with celiac disease may have normal weight or may even be overweight. Indian J Gastroenterol. 2016 Jan;35(1):20–4. doi: 10.1007/s12664–016–0620–9

11. Parada A, Aguirre C, Pérez- Bravo F. Overweight and obesity in celiac disease: expression of the interleukin profile Th 17. Nutr Hosp. 2018 Aug 2;35(4):957–961. doi: 10.20960/nh.1554

12. Nwosu BU, Snook RI, Maranda L. The relationship between adiposity and stature in prepubertal children with celiac disease. J Pediatr Endocrinol Metab. 2013;26(9– 10):819–24. doi: 10.1515/jpem-2012–0312

13. Real Delor RE, López Esquivel NG, Real Aparicio NE. Silent celiac disease in an obese patient with alopecia areata. Rev Fac Cien Med Univ Nac Cordoba. 2020 Mar 13; 77(1):49–51. doi: 10.31053/1853.0605.v77.n1.25193

14. Cemeroglu AP, Eng DS, Most LA, Stalsonburg CM., et al. Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation syndrome and celiac disease in a 13-year-old girl: further evidence for autoimmunity? J Pediatr Endocrinol Metab. 2016 Jan;29(1):97–101. doi: 10.1515/jpem-2015–0129

15. Calcaterra V, Regalbuto C, Madè A, Magistrali M., et al. Coexistence of Excessive Weight Gain and Celiac Disease in Children: An Unusual Familial Condition. Pediatr Gastroenterol Hepatol Nutr. 2019 Jul;22(4):407–412. doi: 10.5223/pghn.2019.22.4.407

16. Ribaldone DG, Saracco GM, Pellicano R. Prevalence of Micronutrient Deficiency in Patients with Morbid Obesity Before Bariatric Surgery: What About Celiac Disease? Obes Surg. 2018 Feb;28(2):550–551. doi: 10.1007/s11695–017–3027–5

17. Lojou M, Sahakian N, Dutour A, Vanbiervliet G., et al. Celiac Disease and Obesity: Is Bariatric Surgery an Option? Obes Surg. 2020 Apr 21. doi: 10.1007/s11695–020–04607-z

18. Capriati T, Francavilla R, Ferretti F, Castellaneta S., et al. The overweight: a rare presentation of celiac disease. Eur J Clin Nutr. 2016 Feb;70(2):282–4. doi: 10.1038/ejcn.2015.169

19. Ghiselli A, Bizzarri B, Gaiani F, Semeraro F., et al. Growth changes after gluteen free diet in pediatric celiac patients: a literature- review. Acta Biomed. 2018 Dec 17;89(9-S):5–10. doi: 10.23750/abm.v89i9-S.7871

20. Diamanti A, Capriati T, Basso MS, Panetta F., et al. Celiac disease and overweight in children: an update. Nutrients. 2014 Jan 2;6(1):207–20. doi: 10.3390/nu6010207

21. Agarwal A, Singh A, Mehtab W, Gupta V., et al. Patients with celiac disease are at high risk of developing metabolic syndrome and fatty liver. Intest Res. 2020 Apr 22. doi: 10.5217/ir.2019.00136

22. Więch P, Chmiel Z, Bazaliński D, Sałacińska I., et al. The Relationship between Body Composition and a Gluten Free Diet in Children with Celiac Disease. Nutrients. 2018 Nov 21;10(11). pii: E1817. doi: 10.3390/nu10111817

23. Barera G, Mora S, Brambilla P, Ricotti A., et al. Body composition in children with celiac disease and the effects of a gluten-free diet: a prospective case-control study. Am J Clin Nutr. 2000 Jul; 72(1):71–5. doi: 10.1093/ajcn/72.1.71. PMID: 10871563

24. Amirikian K, Sansotta N, Guandalini S, Jericho H. Effects of the Gluten-free Diet on Body Mass Indexes in Pediatric Celiac Patients. J Pediatr Gastroenterol Nutr. 2019 Mar; 68(3):360–363. doi: 10.1097/MPG.0000000000002190

25. Reilly NR, Aguilar K, Hassid BG, Cheng J., et al. Celiac disease in normal- weight and overweight children: clinical features and growth outcomes following a gluten-free diet. Pediatr Gastroenterol Nutr. 2011 Nov;53(5):528–31. doi: 10.1097/MPG.0b013e3182276d5e

26. Kabbani TA, Goldberg A, Kelly CP, Pallav K., et al. Body mass index and the risk of obesity in coeliac disease treated with the gluten-free diet. Aliment Pharmacol Ther. 2012 Mar;35(6):723–9. doi: 10.1111/j.1365–2036.2012.05001.x

27. Parfenov A. I., Maev I. V., Baranov A. A. et al. Th e Russian consensus on diagnosis and treatment of coeliac disease in children and adults. Almanac of Clinical Medicine. 2016; 44(6): 661–688. (In Russ.) doi: 10.18786/2072–0505–2016–44–6–661–688

28. Bel’mer S.V., Razumovskii A. Yu., Khavkin A. I., et al. Bowel disease in children. Vol. 1. Moscow. “MEDPRAKTIKA-M” Publ., 2018. (In Russ.)

29. Parfenov A.I., Maev I. G., Baranov A. A. et al. All- Russian Consensus on the Diagnosis and Treatment of Celiac Disease in Children and Adults * Adopted at the 42nd scientific session of the Central Scientific Research Institute of Geology (March 2–3, 2016). Pediatrics. Supplement to the Consilium Medicum magazine, 2016; 1:6–19. (In Russ.)

30. Bel’mer S.V., Havkin A. I. Gluten intolerance and indications for a gluten-free diet. Doctor. 2011; 5: 17–21. (In Russ.)

31. Shapovalova N.S., Novikova V. P., Revnova M. O., et al. Seronegative coeliac disease in the light of the guidelines by the European Society for the Study of Coeliac Disease (ESsCD) 2019. Vopr. det. dietol. 2019; 17(6): 14– 22. (In Russ.) Doi: 10.20953/1727–5784–2019–6–14–22

32. Komarova O.N., Khavkin A. I. Peculiarities of the actual nutrition and nutritional status in children with celiac disease. Pediatria. 2018; 97 (6): 99–103. (In Russ.) Doi: 10.24110/0031–403X-2018–97–6–99–103

33. Shapovalova N. S., Novikova V. P., Revnova M. O., et al. Th e role of HLA-DQ2.2 genotype for patients with celiacia. Experimental and Clinical Gastroenterology. 2018; 159(11): 19–23. (In Russ.) Doi: 10.31146/1682–8658-ecg-159–11–19–23


Review

For citations:


Novikova V.P., Gritsinskaya V.L., Khavkin A.I. Celiac disease and obesity: the possibility of comboridity of pathology in children. Experimental and Clinical Gastroenterology. 2021;(4):124-128. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-188-4-124-128

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