Синдром избыточного бактериального роста с гипераммониемией как причина конгнитивных расстройств

Рост когнитивных нарушений (КН) в клинической практике заставляет проводить поиск их новых патогенетических механизмов, среди которых на сегодняшний день активно изучается влияние на головной мозг кишечной микробиоты. Механизмы взаимодействия оси «мозг - микробиота» окончательно не изучены. Целью данного исследования явилось подтверждение возможного влияния на мозг нейротоксина аммиака, повышающегося в крови вследствие синдрома избыточного бактериального роста (СИБР). Материалы и методы: В статье приводятся данные клинического наблюдения, включающего обследование 70 пациентов гастроцентра г. Перми с синдромом диспепсии, у которых проводилось изучение изменения кишечной микробиоты, уровня аммиака капиллярной крови и нарушений когнитивной сферы, проведен их корреляционный анализ. Результаты: По результатам статистического анализа полученных данных мы не обнаружили достоверных изменений или значимых корреляций между изучаемыми параметрами. Однако, выявленная тенденция в связи «СИБР - гипераммониемия - когнитивные нарушения» позволяет предположить, что наличие СИБР может усугублять тяжесть не только имеющихся гастроэнтерологических проявлений, но и являться фактором риска гипераммониемии, а также вносить свой вклад в формирование нарушений когнитивных функций человека.

кишечная микробиота, головной мозг, когнитивные нарушения, синдром избыточного бактериального роста, аммиак

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