Tissue hypoxia in Crohn’s disease in children: markers and coping methods
https://doi.org/10.31146/1682-8658-ecg-185-1-106-110
Abstract
Objective: to identify markers of tissue hypoxia in Crohn’s disease in children: markers and methods for overcoming it.
Materials and methods: 27 children with Crohn’s disease (CD) aged from 1 year to 18 years were examined. Histological, histomorphometric and immunohistochemical analysis of biopsy samples of the colon mucosa.
Results: morphological markers of tissue hypoxia in CD were identified: the presence of predominantly immature fibroblasts, infiltration of the muscle plate by neutrophilic granulocytes, necrotizing vasculitis, the phenomenon of the grouping of inactive macrophages with each other with the formation of multinucleated cells, which are the precursors of multinucleated granules according to the Pigorov-Lanhans type
Conclusion: in identifying markers of tissue hypoxia, leading to a worsening prognosis of the course of CD and the development of complications, it is necessary to determine the tactics of accelerated “step-up” therapy using anticytokine drugs and use the method of hyperbaric oxygenation.
About the Authors
E. N. Fedulova
Federal State Budgetary Educational Institution of Higher Education «Privolzhsky Research Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Elvira N. Fedulova, MD, DSc, Chief Researcher of the Department of Rheumatological and Other Systemic Diseases
N. Novgorod, pl. Minin Pozharsky, d10 / 1, 603155, Russia
O. V. Shumilova
Federal State Budgetary Educational Institution of Higher Education «Privolzhsky Research Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Olga V. Shumilova, Ph.D., junior researcher of the department of «Rheumatological and other systemic diseases»
N. Novgorod, pl. Minin Pozharsky, d10 / 1, 603155, Russia
N. Yu. Shirokova
Federal State Budgetary Educational Institution of Higher Education «Privolzhsky Research Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Natalya Yu. Shirokova, Ph.D., Researcher, Laboratory and Diagnostic Department, Morphological Research Group
N. Novgorod, pl. Minin Pozharsky, d10 / 1, 603155, Russia
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Review
For citations:
Fedulova E.N., Shumilova O.V., Shirokova N.Yu. Tissue hypoxia in Crohn’s disease in children: markers and coping methods. Experimental and Clinical Gastroenterology. 2021;1(1):106-110. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-185-1-106-110
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