Герпесвирусы и воспалительные заболевания кишечника
https://doi.org/10.31146/1682-8658-ecg-183-11-126-139
Аннотация
Цель. Провести обзор исследований, характеризующих роль герпесвирусных инфекций в патогенезе воспалительных заболеваний кишечника (ВЗК).
Введение. Изучение роли герпесвирусных инфекций в патогенезе ВЗК в настоящее время вызывает значительный интерес исследователей разных стран.
Результат. Приведены результаты исследований о значении вирусов герпеса человека (HHV) при воспалительных заболеваниях кишечника (ВЗК) — язвенном колите (ЯК) и болезни Крона (БК), их влиянии на течение этих заболеваний, рефрактерности к лечению ЯК и БК в присутствии HHV. Показано, что большинство исследователей единодушно приходят к выводу о том, что основное внимание необходимо уделять вирусу Эпштейна-Барр (EBV), цитомегаловирусу (CMV) и вирусу герпеса человека 6 типа (HHV-6), которые обнаруживаются в слизистой оболочке толстой кишки у пациентов с ВЗК и влияют как на течение заболеваний, так и на эффективность лечения. Акцентируется внимание на том, что необходимо дифференцировать колит, обусловленный HHV, и ВЗК, протекающие на фоне реактивации HHV, так как подходы к терапии этих состояний различны.
Заключение. Необходимы целенаправленные исследования на изучение роли герпесвирусов человека в патогенезе ВЗК.
Об авторах
Г. В. Волынец
Российский национальный исследовательский медицинский университет им. Н. И. Пирогова
Россия
Россия
Волынец Галина Васильевна, д. м. н., заведующая отделом гастроэнтерологии, главный научный сотрудник ОСП НИКИ педиатрии им. академика Ю. Е. Вельтищева
125412, Москва, Талдомская улица, дом 2
А. И. Хавкин
Российский национальный исследовательский медицинский университет им. Н. И. Пирогова
Россия
Россия
Хавкин Анатолий Ильич, д. м. н., профессор, главный научный сотрудник отдела гастроэнтерологии ОСП НИКИ педиатрии им. академика Ю. Е. Вельтищева
125412, Москва, Талдомская улица, дом 2
А. В. Никитин
Российский национальный исследовательский медицинский университет им. Н. И. Пирогова
Россия
Россия
Никитин Артём Вячеславович, к. м. н., ведущий научный сотрудник отдела гастроэнтерологии ОСП НИКИ педиатрии им. академика Ю. Е. Вельтищева
125412, Москва, Талдомская улица, дом 2
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Рецензия
Для цитирования:
Волынец Г.В., Хавкин А.И., Никитин А.В. Герпесвирусы и воспалительные заболевания кишечника. Экспериментальная и клиническая гастроэнтерология. 2020;183(11):126-139. https://doi.org/10.31146/1682-8658-ecg-183-11-126-139
For citation:
Volynets G.V., Khavkin A.I., Nikitin A.V. Herpesvirus and inflammatory bowel disease. Experimental and Clinical Gastroenterology. 2020;183(11):126-139. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-183-11-126-139
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