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Экспериментальная и клиническая гастроэнтерология

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Метаболический синдром и беременность. Есть ли гастроэнтерологический след?

https://doi.org/10.31146/1682-8658-ecg-183-11-74-79

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Аннотация

В последние годы в патогенезе метаболического синдрома (МС) большое значение придается неалкогольной жировой болезни печени (НАЖБП) и нарушению микробно-тканевого комплекса кишечника. В настоящем обзоре обобщены современные данные о возможных патофизиологических механизмах, связывающих НАЖБП, нарушение микробно-тканевого комплекса кишечника и беременность. Анализируются клинические последствия влияния НАЖБП на беременность, развитие акушерских осложнений и неблагоприятных перинатальных исходов.

Об авторах

Е. С. Иванюк
ФГБВОУ ВО «Военно-медицинская академия им. С. М. Кирова» МО РФ
Россия

Иванюк Елена Сергеевна, к. м. н., преподаватель 2 кафедры (терапии усовершенствования врачей)

194044, Санкт-Петербург, улица Академика Лебедева, дом 6



С. П. Саликова
ФГБВОУ ВО «Военно-медицинская академия им. С. М. Кирова» МО РФ
Россия

Саликова Светлана Петровна, д. м. н., доцент, доцент 2 кафедры (терапии усовершенствования врачей)

194044, Санкт-Петербург, улица Академика Лебедева, дом 6



Г. Ю. Иванюк
Государственное бюджетное учреждение здравоохранения Пермского края «Ордена «Знак Почёта» Пермская краевая клиническая больница
Россия

Иванюк Галина Юрьевна, заведующая женской консультацией Пермского краевого перинатального центра, врачакушер-гинеколог высшей квалификационной категории

614990, г. Пермь, ул. Пушкина, д. 85



Список литературы

1. Saklayen MG. The Global Epidemic of the Metabolic Syndrome. Curr Hypertens Rep. 2018; 20(2):12.

2. Lee C, Tsenkova VK, Boylan JM, et al. Gender differences in the pathways from childhood disadvantage to metabolic syndrome in adulthood: An examination of health lifestyles. SSM Popul Health. 2018;4: 216–224.

3. Ramos RG, Olden K. The prevalence of metabolic syndrome among US women of childbearing age. Am J Public Health. 2008; 98(6):1122–1127.

4. Szostak-Węgierek D, Waśkiewicz A, Piotrowski W, et al. Metabolic syndrome and its components in Polish women of childbearing age: a nationwide study [published correction appears in BMC Public Health. 2017 Sep 22;17 (1):736]. BMC Public Health. 2017;18(1):15.

5. Tavares HP, Arantes MA, Tavares SB, et al. Metabolic Syndrome and Pregnancy, Its Prevalence, Obstetrical and Newborns Complications. Open Journal of Obstetrics and Gynecology 2015; 5(11) 618–625.

6. Dorobantu M, Onciul S, Tautu OF, et al. Hypertension and Ischemic Heart Disease in Women. Curr Pharm Des. 2016; 22(25):3885–3892.

7. Саликова С. П. Аритмии у беременных: клиника, диагностика, лечение: автореферат дис. … кандидата медицинских наук. – Оренбург, 1996. – 15 с.

8. Mendrick DL, Diehl AM, Topor LS, et al. Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic. Toxicol Sci. 2018;162(1):36–42.

9. Santangeli L, Sattar N, Huda SS. Impact of maternal obesity on perinatal and childhood outcomes. Best Pract Res Clin Obstet Gynaecol. 2015; 29(3):438–448.

10. Kautzky-Willer A, Harreiter J, Winhofer-Stöckl Y, et al. Gestations diabetes (GDM) (Update 2019). Wien Klin Wochenschr. 2019;131(Suppl 1):91–102.

11. Grieger JA, Bianco-Miotto T, Grzeskowiak LE, et al. Metabolic syndrome in pregnancy and risk for adverse pregnancy outcomes: A prospective cohort of nulliparous women. PLoS Med. 2018;15(12): e1002710.

12. Хромылев А. В. Метаболический синдром и беременность. Ожирение и метаболизм. 2014;(2): 3–7.

13. Хромылев А. В., Макацария А. Д. Патогенетические механизмы тромбоэмболических осложнений метаболического синдрома у беременных. Акушерство, гинекология и репродукция. 2014;1:68–73.

14. Napso T, Yong HEJ, Lopez-Tello J, et al. The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation. Front Physiol. 2018; 9:1091.

15. Шварц В. Я. Воспаление жировой ткани (часть 5). Взаимосвязь с физиологической инсулинорезистентностью. Проблемы эндокринологии. 2011;6, 64–70.

16. Cheng C, Wei H, Yu H, et al. Metabolic Syndrome During Perinatal Period in Sows and the Link With Gut Microbiota and Metabolites. Front Microbiol. 2018;9:1989.

17. Kong XF, Ji YJ, Li HW, et al. Colonic luminal microbiota and bacterial metabolite composition in pregnant Huanjiang mini-pigs: effects of food composition at different times of pregnancy. Sci Rep. 2016;6:37224.

18. Salzer L, Tenenbaum-Gavish K, Hod M. Metabolic disorder of pregnancy (understanding pathophysiology of diabetes and preeclampsia). Best Pract Res Clin Obstet Gynaecol. 2015;29(3):328–338.

19. Chassaing B, Gewirtz AT. Gut microbiota, low-grade infl ammation, and metabolic syndrome. Toxicologic Pathology. 2014; 42:49–53.

20. Collado MC, Isolauri E, Laitinen K, et al. Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women. American Journal of Clinical Nutrition. 2008; 88:894–899.

21. Santacruz A, Collado MC, Garcia-Valdes L, et al. Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women. The British Journal of Nutrition. 2010; 104:83–92.

22. Cani PD, Osto M, Geurts L, et al. Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity. Gut microbes. 2012; 3:279–288.

23. Edwards SM, Cunningham SA, Dunlop AL, Corwin EJ. The Maternal Gut Microbiome During Pregnancy. MCN Am J Matern Child Nurs. 2017;42(6):310–317.

24. Hershman M, Mei R, Kushner T. Implications of nonalcoholic fatty liver disease on pregnancy and maternal and child outcomes. Gastroenterol Hepatol (NY). 2019; 15:221–8.

25. Younossi ZM, Koenig AB, Abdelatif D, et al. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64:73–84.

26. Yki-Jarvinen H. Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome. Lancet Diabetes Endocrinol. 2014; 2:901–10.

27. Azzaroli F, Mazzella G, Marchesini G, et al. Fatty liver in pregnancy: a narrative review of two distinct conditions. Expert Rev Gastroenterol Hepatol. 2020;14(2):127–135.

28. Westbrook RH, Dusheiko G, Williamson C. Pregnancy and liver disease. J Hepatol. 2016;64:933–45.

29. Garcia-Romero CS, Guzman C, Cervantes A, et al. Liver disease in pregnancy: Medical aspects and their implications for mother and child. Ann Hepatol. 2019; 18:553–62.

30. Stupin JH, Arabin B. Overweight and Obesity before, during and after Pregnancy: Part 1: Pathophysiology, Molecular Biology and Epigenetic Consequences. Geburtshilfe Frauenheilkd. 2014;74(7):639–645.

31. Reynolds RM, Allan KM, Raja EA et al. Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult off spring: follow-up of 1323275 person years. BMJ 2013; 347: f4539.

32. Salem SY, Kessous R, Pariente G et al. Obesity in pregnancy: whats next? Long-term cardiovascular morbidity in a follow-up period of more than a decade. Am J Obstet Gynecol 2014; 210 (1. Suppl.): S45, S68.

33. Herath RP, Siriwardana SR, Ekanayake CD, et al. Nonalcoholic fatty liver disease and pregnancy complications among Sri Lankan women: A cross sectional analytical study. PLoS One. 2019;14(4): e0215326.

34. Martino J, Sebert S, Segura MT, et al. Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes. J Clin Endocrinol Metab. 2016;101(1):59–68.

35. Pantham P, Aye IL, Powell TL. Inflammation in maternal obesity and gestational diabetes mellitus. Placenta. 2015;36(7):709–715.

36. Challier JC, Basu S, Bintein T, et al. Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta. 2008;29(3):274–281.

37. Ramsay JE, Ferrell WR, Crawford L, et al. Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways. J Clin Endocrinol Metab. 2002; 87(9):4231–4237.

38. Basu S, Haghiac M, Surace P, et al. Pregravid obesity associates with increased maternal endotoxemia and metabolic infl ammation. Obesity (Silver Spring). 2011;19(3):476–482.

39. Sarkar M, Grab J, Dodge JL, et al. Non-alcoholic fatty liver disease in pregnancy is associated with adverse maternal and perinatal outcomes. J Hepatol. 2020; S0168–8278(20)30215–4.

40. Макаров И.О., Боровкова Е. И., Казаков Р. Распространенность неалкогольной жировой болезни печени у беременных с ожирением «Акушерство, гинекология, репродукция», 2012, т. 6, № 4. с. 18–21

41. Zhou M-S, Schulman IH, Zeng Q. Link between the reninangiotensin system and insulin resistance: implications for cardiovascular disease. Vasc Med 2012;17(5):330–341.

42. Park MJ, Lee DH, Joo BS, et al. Leptin, leptin receptors and hypoxia-induced factor-1α expression in the placental bed of patients with and without preeclampsia during pregnancy. Mol Med Rep. 2018;17(4):5292–5299.

43. Pérez-Pérez A, Toro A, Vilariño-García T, et al. Leptin action in normal and pathological pregnancies. J Cell Mol Med. 2018;22(2):716–727.

44. Th agaard IN, Hedley PL, Holm JC, et al. Leptin and Adiponectin as markers for preeclampsia in obese pregnant women, a cohort study. Pregnancy Hypertens. 2019;15:78–83.

45. Hagström H, Höijer J, Ludvigsson JF, et al. Adverse outcomes of pregnancy in women with non-alcoholic fatty liver disease. Liver Int. 2016;36(2):268–274.

46. You S, Cui AM, Hashmi SF, et al. Dysregulation of bile acids increases the risk for preterm birth in pregnant women. Nat Commun. 2020;11(1):2111.

47. Lavery JA, Friedman AM, Keyes KM, et al. Gestational diabetes in the United States: temporal changes in prevalence rates between 1979 and 2010. BJOG. 2017;124(5):804–813.

48. Law KP, Zhang H. The pathogenesis and pathophysiology of gestational diabetes mellitus: Deductions from a three-part longitudinal metabolomics study in China. Clin Chim Acta. 2017;468:60–70.

49. Lee SM, Kwak SH, Koo JN, et al. Non-alcoholic fatty liver disease in the fi rst trimester and subsequent development of gestational diabetes mellitus. Diabetologia. 2019;62(2):238–248.

50. Ajmera VH, Gunderson EP, VanWagner LB, Lewis CE, Carr JJ, Terrault NA. Gestational diabetes mellitus is strongly associated with non-alcoholic fatty liver disease. Am J Gastroenterol. 2016;111(5):658–664.

51. Bao W, Baecker A, Song Y, Kiely M, Liu S, Zhang C. Adipokine levels during the fi rst or early second trimester of pregnancy and subsequent risk of gestational diabetes mellitus: A systematic review. Metabolism. 2015;64(6):756–764.


Для цитирования:


Иванюк Е.С., Саликова С.П., Иванюк Г.Ю. Метаболический синдром и беременность. Есть ли гастроэнтерологический след? Экспериментальная и клиническая гастроэнтерология. 2020;183(11):74-79. https://doi.org/10.31146/1682-8658-ecg-183-11-74-79

For citation:


Ivanyuk E.S., Salikova S.P., Ivanyuk G.Yu. Metabolic syndrome and pregnancy. Is there a gastroenterological trace? Experimental and Clinical Gastroenterology. 2020;183(11):74-79. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-183-11-74-79

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