Colorectal bradyarrhythmia syndrome as a predictor of metabolic syndrome
https://doi.org/10.31146/1682-8658-ecg-183-11-44-50
Abstract
Evidence is presented for a significantly wider spread of the first two stages (mild and moderate) Colorectal Bradyarrhythmia Syndrome (CBS) compared with the third (severe — constipation) stage of this syndrome. Surveyed more than 2,500 medical professionals by the method of chronoenterographia. It was found that the incidence of mild CBS (about 60% of cases) and moderate stage of this syndrome (about 30% of cases) is almost an order of magnitude higher than the incidence of severe stage (about 10% of cases) of CBS. SCB has been shown to increase the risk of obesity by almost 3 times. It is shown that CBS contributes to a decrease in well-being, activity and mood, as well as a decrease in the quality of life. Screening for CBS and normalizing the circadian bowel rhythm with psyllium (mucofalc) in individuals who consider themselves healthy may contribute to early prevention of the risk of the metabolic syndrome.
About the Authors
K. A. Shemerovskii
Saint Petersburg Medical and Social Institut
Russian Federation
Russian Federation
Konstantin A. Shemerovskii, doctor of medical sciences, Associate Professor of the Department of Internal Diseases
195271, Saint-Petersburg, Kondratyevskiy pr., 72, litera. A
V. N. Fedorets
Saint Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Viktor N. Fedorets, Doctor of Science Associate Professor of internal diseases department named after professor V. A. Valdmana
194100, Saint-Petersburg, Litovskaya st. 2
P. V. Seliverstov
North-Western State Medical University named after I. I. Mechnikov
Russian Federation
Russian Federation
Pavel V. Seliverstov, candidate of medical sciences, Associate Professor of the Department of Internal Diseases, Сlinical Pharmacology and Nephrology
191015, Saint-Petersburg, Kirochnay st., 41
S. R. Bakaeva
North-Western State Medical University named after I. I. Mechnikov
Russian Federation
Russian Federation
Sofia R. Bakaeva, resident physician of the Department of Internal Diseases, Сlinical Pharmacology and Nephrology
191015, Saint-Petersburg, Kirochnay st., 41
References
1. Klimov A. N., Nikulcheva N. G. Lipids, lipoproteins and atherosclerosis, 1995. 304 p., (In Russ.)
2. Lazebnik L. B., Zvenigorodskaya L. A. Metabolic syndrome and digestive organs. – Anacharsis, 2009. 184 p. (In Russ.)
3. Belyakov N. A., Seidova G. B., Chubrieva S. Yu., Glukhov N. V. Metabolic syndrome in women (pathophysiology and clinical picture). SPb .: Publishing house SPbMAPO, 2005. 440 p. (In Russ.)
4. Shemerovskii, K. A. Bulletin of Experimental Biology and Medicine (2002) 133: 506. https://doi.org/10.1023/A:1019834409733.
5. Shemerovskii, K. A. Bulletin of Experimental Biology and Medicine (2002) 134: 565. https://doi.org/10.1023/A:1022965212971
6. Shemerovskii KA, Ovsiannikov VI, Stoliarov ID, Nikiforova IG. Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(2 Pt 2):60–63.
7. Watanabe T, Nakaya N, Kurashima K. Constipation, laxative use and risk of colorectal cancer: The Miyagi Cohort Study. Eur J Cancer 2004 Sep; 40(14):2109–15.
8. Tashiro N, Budhathoki S, Ohnaka K, et al. Constipation and colorectal cancer risk: the Fukuoka Colorectal Cancer Study. Asian Pac J Cancer Prev. 2011; 12(8):2025–30.
9. Guerin A, Mody R, Fok B et al. Risk of developing colorectal cancer and benign colorectal neoplasm in patients with chronic constipation. Alim. Pharm. Ther. 2014 Jul; 40(1):83–92.
10. Averin E. E. Outpatient patient with arterial hypertension: is it important to consider Well-being-ActivityMood? Pharmateca. 2010. no. 10. pp. 56–59. (In Russ.)
11. Honkura K., Tomata Y., Sugiyama K. et al. Defecation frequency and cardiovascular disease mortality in Japan: The Ohsaki cohort study. Atherosclerosis. 2016. No.246, pp. 251–256.
12. Ma W, Li Y, Heianza Y., et al. Associations of Bowel Movement Frequency with Risk of Cardiovascular Disease and Mortality among US Women. Sci Rep. 2016 Sep 6;6: 33005.
13. Kubota Y., Iso H., Tamakoshi A. Bowel Movement Frequency, Laxative Use, and Mortality From Coronary Heart Disease and Stroke Among Japanese Men and Women: The Japan Collaborative Cohort (JACC) Study. J Epidemiol. 2016 May 5; 26(5):242–8.
14. Shemerovsky K. A., Seliverstov P. V., Bochkarev M. V., Shaidullina S. R. Chronophysiological mechanism of regularity of circadian rhythm of evacuation function of the intestine. Experimental and clinical gastroenterology. 2019 b; 165(5): 150–153. DOI: 10.31146/1682–8658ecg-165–5–150–153.
15. Shemerovskii K.A, Shabanov P. D., Ovsiannikov V. I, Mitreikin V. F., Seliverstov P. V., Iurov A. Iu. Colorectal Bradyarrhythmia Syndrome as Predictor of Constipation and Colorectal Cancer. UEG Week-2019, October 19–23, 2019, Barcelona, Spain, P0522.
16. Shemerovskii K.A, Ovsiannikov V. I, Mitreikin V. F. Irregular Bowel Habit Increases Risk of Obesity. United European Gastroenterology Journal, 2015, 3 (5S), A504, 1223 P.
17. Shemerovsky K. A. Indicators of mental health in persons with regular and irregular rhythm of the bowel. Scientific notes of the State medical University named after Acad. I. P. Pavlova, 2013, Vol. 20, No. 3, pp. 68–71.
18. Vander M. A., Shemerovsky K. A. Quality of life of patients with arterial hypertension and the regularity of the enteral rhythm. Actual problems of clinical and experimental medicine. SPb SPbMAPO. 2002, pp. 5–6. (In Russ.)
19. Shemerovsky K. A., Zhukova T. L. Arterial Hypertension, vol. 14, no. 2, 2008, 110 p. (In Russ.)
20. Boytsov S. A., Lazebnik L. B., Levchenko S. V., Komissarenko I. A. Rational pharmacotherapy of the symptomatic uncomplicated colon diverticular disease. Experimental and Clinical Gastroenterology. 2018;(5):86–92. (In Russ.)
21. Levchenko S. V., Komissarenko I. A. Psyllium as a lipid-lowering agent: results of a multicenter study. Doctor 2018. vol. 29, no. 1, pp.16–24. (In Russ.)
22. Komissarenko I. A., Levchenko S. V., Gudkova R. B., Silvestrova S. Yu. Effects of long-term use of psyllium in the treatment of patients with diverticular disease of the colon. KPGG, 2014: 3: 29–36. (In Russ.)
23. Bays H, Stein E. A. Pharmacotherapy for dyslipidaemia – current therapies and future agents. Expert Opin Pharmacother. 2003 Nov;4(11):1901–38.
Review
For citations:
Shemerovskii K.A., Fedorets V.N., Seliverstov P.V., Bakaeva S.R. Colorectal bradyarrhythmia syndrome as a predictor of metabolic syndrome. Experimental and Clinical Gastroenterology. 2020;183(11):44-50. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-183-11-44-50
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