Tissue hypoxia as a cause of unsuccessful treatment of ulcerative colitis in children: markers and methods of overcoming
https://doi.org/10.31146/1682-8658-ecg-180-8-93-97
Abstract
Objective: to identify markers of tissue hypoxia in ulcerative colitis and methods for overcoming it.
Materials and methods: 77 children with ulcerative colitis (UC) aged 1 year to 18 years were examined. Retrospectively analyzed biopsy samples in patients with verifi ed course of ulcerative colitis, including those operated on, during initial hospitalization.
Histological, histomorphometric and immunohistochemical analysis of biopsy samples of the mucous membrane of the colon and ileum was performed.
Results: morphological markers of tissue hypoxia in UC were revealed: increased fi broplastic activity, small focal lipomases, small intestinal metaplasia in the distal colon, determined by the presence of Paneth cells, changes in the distal ileum in the colon type.
Conclusion: when identifying markers of tissue hypoxia, leading to a worsening prognosis of UC and the ineff ectiveness of therapeutic treatment, it is necessary to use accelerated “step-up” therapy, including the early administration of anticytokine drugs and use the hyperbaric oxygenation method.
About the Authors
E. N. Fedulova
Federal State Budgetary Educational Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Elvira N. Fedulova - Doctor of Medical Sciences, Chief Researcher, Department of Rheumatology and Other Systemic Diseases.
10/1, Minin and Pozharsky Sq., Nizhny Novgorod, 603950
O. A. Tutina
Federal State Budgetary Educational Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Olga A. Tutina - Researcher at the Department of Rheumatology and other Systemic Diseases.
10/1, Minin and Pozharsky Sq., Nizhny Novgorod, 603950
G. V. Medyantseva
Federal State Budgetary Educational Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Galina V. Medyantseva - Pediatrician of the first pediatric department with medical rehabilitation.
10/1, Minin and Pozharsky Sq., Nizhny Novgorod, 603950
References
1. Baranov A. A., Potapov A. S., Tsimbalova E. G. Modern technologies for the diagnosis and treatment of inflammatory bowel diseases in children. Bulletin of the RAMS. 2011. No. 6, pp. 36–41.
2. Kornienko, E. A. Infl ammatory bowel disease in children. Moscow. Prima Print, 2014, 208 p.
3. Vorobiev G. I., Khalif I. L. Inflammatory bowel disease. Moscow, Miklos, 2008, 424 p.
4. P. P. Potekhin, E. N. Fedulova, V. N. Kopeikin, A. R. Bogomolov, G. M. Lukoyanova, O. A. Tutin. Method for predicting the course of ulcerative colitis in children: US Pat. No. 2287817 Rus. Federation IPC G01N33 / 483 (2006.01). applicant and patentee «Nizhny Novgorod Research Institute of Pediatric Gastroenterology».
5. D. Turner, A. Levine, J C. Escher, et al. Management of pediatric ulcerative colitis: joint ECCO and ESPGHAN evidencebased consensus guidelines. JPGN. 2012;55(3):340–361.
6. Potapov A. S., Alieva E. I., Gabruzskaya T. V., et al. Clinical manifestation, diagnostics and treatment of ulcerative colitis in children: russian pediatric consensus. Current Pediatrics. 2013;12(3):18–30. (In Russ.) https://doi.org/10.15690/vsp.v12i3.677
Review
For citations:
Fedulova E.N., Tutina O.A., Medyantseva G.V. Tissue hypoxia as a cause of unsuccessful treatment of ulcerative colitis in children: markers and methods of overcoming. Experimental and Clinical Gastroenterology. 2020;(8):93-97. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-180-8-93-97
Views:
387
Email this article 