Correction of micronutrient deficiency for the prevention of intrahepatic cholestasis in pregnant women
https://doi.org/10.31146/1682-8658-ecg-180-8-66-71
Abstract
Objective: to analyze the actual nutrition of pregnant women in order to identify the prevalence of deficiency of selenium and zinc, as well as to trace the relationship of the deficiency of these trace elements with the development of intrahepatic cholestasis.
Materials and methods. A qualitative assessment of actual nutrition during pregnancy was carried out on the basis of profi les of 417 women in the first trimester of pregnancy. The second stage of the study evaluated the serum content of selenium, zinc and vitamin D3 in 35 patients using inductively coupled plasma spectrometry, the pregnancy of which was complicated by intrahepatic cholestasis (main group) compared with women with physiological pregnancy (50 people).
Results. It was shown that a deficiency of selenium and zinc is associated with a risk of developing HCB, as evidenced by an increase in the relative risk indicator (RR = 1.456 and RR = 1.252 with a deficiency of selenium and zinc, respectively). The prevalence of vitamin D3 deficiency is currently ubiquitous, we noted lower rates in the group of patients with HCB compared with uncomplicated gestation (10.6 ± 2.1 ng / ml and 25.8 ± 1.8 ng / ml, respectively), between groups confirmed significant differences (p <0,0). However, no infl uence on the risk of developing HCB was detected (RR = 0.909).
With a combined deficiency of selenium, zinc and vitamin D3, the risk of developing intrahepatic cholestasis is significantly increased (RR = 5.694).
Findings. A promising direction for the prevention of obstetric complications, including in relation to the pathology of internal organs, and not only the placental complex, is the eff ect on the socalled controlled factors, which include the correction of nutrient deficiencies.
About the Authors
G. K. Sadykova
Perm State Medical University named after Academician E. A. Wagner (PSMU)
Russian Federation
Russian Federation
Gulnara K. Sadykova - Candidate of Medical Sciences, Associate Professor of the Department of Obstetrics and Gynecology № 1; SPIN: 8730–4583.
614000, Perm, st. Petropavlovskaya, 26
A. A. Olina
D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
Russian Federation
Russian Federation
Anna A. Olina - Doctor of Medical Sciences, Professor, First Deputy Director; SPIN: 4255–4325.
199034, St. Petersburg, Mendeleevskaya Liniya, 3
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Review
For citations:
Sadykova G.K., Olina A.A. Correction of micronutrient deficiency for the prevention of intrahepatic cholestasis in pregnant women. Experimental and Clinical Gastroenterology. 2020;(8):66-71. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-180-8-66-71
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