Gastroesophageal reflux disease in comorbidity with obstructive sleep apnea syndrome and non-alcoholic fatty liver disease
https://doi.org/10.31146/1682-8658-ecg-180-8-34-38
Abstract
Gastroesophageal reflux disease (GERD), non-alcoholic fatty liver disease (NAFLD) and obstructive sleep apnea syndrome (OSAS) are common diseases associated with obesity, abdominal obesity and metabolic syndrome. Each of the diseases has a negative effect on other organ systems, causing cardiovascular morbidity and mortality. Due to the commonality of etiopathogenetic mechanisms, the interrelationships of GERD, NAFLD, and OSAS are of research interest. Most of the work done on this issue demonstrates a relationship between them, independent of body mass index, waist circumference, lipid and carbohydrate metabolism. At the same time, NAFLD is considered as an independent predictor of symptoms of GERD and erosive esophagitis. OSAS is signifi cantly associated with an increased risk of hepatic steatosis, its progression to steatohepatitis and liver fibrosis. GERD is associated with a more severe form of OSAS, and OSAS is associated with the development of Barrett’s esophagus and adenocarcinoma of the esophagus. Meanwhile, the numerous publications available in modern literature are controversial. The issues of combining GERD, NAFLD and OSAS from the standpoint of mutual causality and / or the impact of common risk factors have not been fully resolved. Some aspects of the influence of GERD on the possible progression of NAFLD and OSAS remain unclear.
About the Authors
B. B. Dambaeva
Irkutsk State Medical Academy of Postgraduate Education — Branch Campus of the Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Bairma B. Dambaeva - Department of Therapy, Postgraduate Student
E. V. Onuchina
Irkutsk State Medical Academy of Postgraduate Education — Branch Campus of the Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Elena V. Onuchina - Department of Therapy, Professor of the Department of Therapy, Doctor of Medical Sciences
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For citations:
Dambaeva B.B., Onuchina E.V. Gastroesophageal reflux disease in comorbidity with obstructive sleep apnea syndrome and non-alcoholic fatty liver disease. Experimental and Clinical Gastroenterology. 2020;(8):34-38. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-180-8-34-38
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