Gastrointestinal symptoms of migraine in children and adolescents
https://doi.org/10.31146/1682-8658-ecg-178-6-112-118
Abstract
Objective: to study the characteristics, frequency of occurrence, and clinical signifi cance of nausea, vomiting, abdominal pain associated with a migraine attack, in children and adolescents.
Materials and methods. Included 32 patients aged 7 years to 18 years with a diagnosis of episodic migraine. All patients were carefully analyzed for nausea, vomiting, and abdominal pain accompanying a migraine attack.
Results. Nausea bothered 78% of patients, the median of its intensity corresponded to pronounced. Vomiting accompanied attacks in 68%, the median of its quantity—3 per day. Attack pain in the abdomen developed in 6% of patients. Moreover, the early onset of migraine seizures is associated with severe nausea and vomiting (p = 0,015 and p = 0,043, respectively). Among male patients, direct correlations were obtained between headache intensity and nausea intensity (rS = 0,456, p = 0,029, n = 23) and the amount of vomiting (rS = 0,417, p = 0,048, n = 23).
Conclusion.
1. With migraine in children and adolescents, nausea and vomiting are often seen as symptoms associated with an attack, while abdominal pain is a rare manifestation of a migraine attack.
2. There is a negative relationship between the age of the patient and the intensity of vomiting, the early onset of migraine attacks is often associated with severe nausea and vomiting, and in male patients, the intensity of the headache directly correlates with the intensity of nausea and the amount of vomiting.
3. There was no dependence of gastrointestinal manifestations on the patient’s gender, the presence of an aura during an attack, the frequency of attacks and the number of pain days.
About the Authors
O. V. Serousova
South-Ural State Medical University
Russian Federation
Russian Federation
Associate Professor of the Department of Nervous Diseases, Cand. of Med. Sci.,
64, Vorovskogo str., Chelyabinsk, 454092
M. I. Karpova
South-Ural State Medical University
Russian Federation
Russian Federation
Head of the Department of Nervous Diseases, MD,
64, Vorovskogo str., Chelyabinsk, 454092
A. I. Dolgushina
South-Ural State Medical University
Russian Federation
Russian Federation
Head of the Department of Hospital Therapy, MD,
64, Vorovskogo str., Chelyabinsk, 454092
D. B. Kulikova
South-Ural State Medical University
Russian Federation
Russian Federation
5 year student,
64, Vorovskogo str., Chelyabinsk, 454092
References
1. Feigin V. L., Abajobir A. A., Abate K. H. et al. Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 // The Lancet Neurology. – 2017. – Vol.16, № 11. – P. 877–897.
2. Maytal J., Young M., Shechter A., Lipton R. B. Pediatric migraine and the International Headache Society (IHS) criteria // Neurology. – 1997. –Vol. 48, № 3. –P. 602–607.
3. Lipton R. B., Buse D. C., Saiers J. et al. Frequency and Burden of Headache-Related Nausea: Results From the American Migraine Prevalence and Prevention (AMPP) Study // Headache. – 2013. – Vol. 53. – P. 93–103.
4. Osipova VV, Filatova EG, Artemenko AR, et al. Diagnosis and treatment of migraine: Recommendations of the Russian experts. S. S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S. S. Korsakova. 2017;117(1):28–42. https://doi.org/10.17116/jnevro20171171228–42.
5. Láinez M., García Casado A., Gascón C. Optimal management of severe nausea and vomiting in migraine: improving patient outcomes // Patient Related Outcome Measures. – 2013. – Vol. 4. – P. 61–73.
6. Wilcox S. L., Ludwick A. M., Lebel A., Borsook D. Age- and sex-related differences in the presentation of paediatric migraine: A retrospective cohort study // Cephalalgia. – 2017. – Vol. 38, № 6. – P. 1107–1118.
7. Headache Classification Committee of the International Headache Society (IHS) The International Classifi cation of Headache Disorders, 3rd edition // Cephalalgia. – 2018. – Vol. 38, № 1. – P. 1–211.
8. Eidlitz-Markus T., Gorali O., Haimi-Cohen Y., Zeharia A. Symptoms of Migraine in The Paediatric Population by Age Group // Cephalalgia. – 2008. – Vol. 28, № 12. – P. 1259–1263.
9. Kóbor J., Nyári T., Benedek G., Túri S. Age-related prevalence and features of migraine headache in Hungarian schoolchildren and adolescents // European Journal of Paediatric Neurology. – 2013.–Vol. 17, № 6.–P. 600–607.
10. Tarasco V., Grasso G., Versace A. et al. Epidemiological and clinical features of migraine in the pediatric population of Northern Italy // Cephalalgia. – 2015. – Vol. 36, № 6. – P. 510–517.
11. Aamodt A. H., Stovner L. J., Hagen K., Zwart J-A. Comorbidity of headache and gastrointestinal complaints. Th e Head-HUNT Study // Cephalalgia. – 2008. Vol. 28. – P. 144–151.
12. Roger K. Cady, Kathleen Farmer, J. Kent Dexter, Jessica Hall. The Bowel and Migraine: Update on Celiac Disease and Irritable Bowel Syndrome // Curr Pain Headache Rep. – 2012. – Vol. 16. – P. 278–286.
13. Lau C. I., Lin C. C., Chen W. H., Wang H. C., Kao C. H. Association between migraine and irritable bowel syndrome: a population-based retrospective cohort study // European Journal of Neurology. – 2014. – Vol. 21. – P. 1198–1204.
14. Karpova M. I., Dolgushina A. I., Serousova O. V., Vasilenko A. F., Korotkova D. G. Migraine and pathology of the gastrointestinal tract. Russian neurological journal. 2019; 24(2):12–22
15. Napthali K., Koloski N., Talley N. J. Abdominal migraine // Cephalalgia. – 2016.–Vol. 36, № 10.–P. 980–986.
16. Albers L., von Kries R., Straube A. et al. Do pre-school episodic syndromes predict migraine in primary school children? A retrospective cohort study on health care data // Cephalalgia. – 2018. Vol. 0, № 0. – P. 1–7.
17. Arruda M. A., Bigal M. E. Migraine and migraine subtypes in preadolescent children: Association with school performance // Neurology. – 2012. – Vol. 79, № 18. – P. 1881–1888.
18. Raieli V., Trapolino D., Giordano G. et al. Juvenile Migraine and Allodynia: Results of a Retrospective Study // Headache: The Journal of Head and Face Pain. – 2015. – Vol. 55, № 3. – P. 413–418.
Review
For citations:
Serousova O.V., Karpova M.I., Dolgushina A.I., Kulikova D.B. Gastrointestinal symptoms of migraine in children and adolescents. Experimental and Clinical Gastroenterology. 2020;(6):112-118. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-178-6-112-118
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