Retrospective analysis of gastrointestinal pathology associated with Takayasu arteritis
https://doi.org/10.31146/1682-8658-ecg-178-6-101-105
Abstract
Background: Takayasu arteritis (TA) is a systemic vasculitis, affecting mainly large aortal branches. AT is considered to be a rare disease [1]. TA actual frequency in the general population is not estimated due to a number of objective and subjective factors [2]. Gastrointestinal (GI) diseases in TA patients are not sufficiently studied. GI involvement can be a consequence of the main pathological process as well as drug treatment complication. The need to analyze the frequency and structure associated with at lesions of the digestive system determines the relevance of this work.
Objective: in a retrospective cohort study to assess the frequency and structure of TA-associated GI pathology.
Materials and methods: a retrospective cohort study included 183 patients with verifi ed TA. All had been hospitalized and observed in the Sverdlovsk regional Clinical Hospital 1 from 1979 to 2018, and were examined according to the clinical guidelines valid by the period of hospitalization. The results of 22 fatal cases autopsies were also analyzed. The study was approved by the local Ethical Committee, the Sverdlovsk Regional Clinical Hospital 1.
Results: GI diseases were registered in 70 (38%) of the cohort 183 participants. The most frequently registered GI disease was chronic gastritis (28 cases; 40%), nonalcoholic fatty liver disease (22 cases; 31%), chronic pancreatitis (33 cases; 47%). Meanwhile, GI lesion was confi rmed in 20 cases of autopsy (87%). Moreover, 2 tumors of the stomach and hepar were revealed only postmortem.
Conclusion: the data obtained emphasize the importance of more thorough clinical and instrumental monitoring of the GI tract in TA patients.
About the Authors
I. E. Borodina
Urals State Medical University;
Sverdlovsk Regional Clinical Hospital 1
Russian Federation
Russian Federation
general practitioner,
Yekaterinburg
A. B. Spirin
Urals State Medical University;
Central City Clinical Hospital № 1 of the Oktyabrsky District
Russian Federation
Russian Federation
Cand. of Med. Sci., Associate Professor of the department of pathological anatomy and forensic medicine,
Yekaterinburg
A. A. Popov
Urals State Medical University
Russian Federation
Russian Federation
M. D., Ph. D., Head, Hospital Therapy and Emergency Medicine Department,
Yekaterinburg
N. A. Osadchaya
Urals State Medical University;
Sverdlovsk Regional Clinical Hospital 1
Russian Federation
Russian Federation
M. D., Ph. D, docent of the department of postgraduated therapy,
Yekaterinburg
A. A. Kozulin
Urals State Medical University
Russian Federation
Russian Federation
assistant of the department of postgraduated therapy,
Yekaterinburg
References
1. Bokeria L. A., Pokrovsky A. V., Sokurenko G. Yu. et al. National guidelines for the management of patients with diseases of the brachiocephalic arteries. Russian conciliation document. Moscow, 2013, 72 p.
2. Nasonov E. L., Nasonova V. A. Rheumatology. National Manual. Moscow. Publishing House “GEOTAR – Media”. 2010, PP. 539–567.
3. Beketova T. V., Nasonov E. L. Innovative Treatments For Takayasu’s Arteritis: A Focus On Interleukin-6 Inhibitors. Th e Authors’ Experience With Tocilizumab And A Review Of Literature. Rheumatology Science and Practice. 2017;55(5):536–548. (In Russ.)] https://doi. org/10.14412/1995-4484-2017-536-548
4. Vargas-Alarcón G, Soto ME, Pérez-Hernández N, Cicero-Sabido R, Ramírez E, Alvarez-León E, Reyes PA. Comparative study of the residues 63 and 67 on the HLA-B molecule in patients with Takayasu’s arteritis and tuberculosis.// Cell Biochem Funct. 2008; 26(7): 820–823.
5. Lectures on General pathological anatomy. Textbook./ Ed. by academician of RAS and RAMS, Professor M. A. Paltsev. M., 2003, 254 p. (in Rus.)
6. Mukhin NA, Smitienko IO, Novikov PI, et al. Clinical manifestations and outcomes of Takayasu arteritis in the cohort study in 128 patients. Clinical Pharmacology and Therapy = Klinicheskaya Farmakologiya i Terapiya. 2014;23(3):55–61 (In Russ.)
7. Strukov A. I., Serov V. V. Pathological anatomy: textbook. – 5th ed., stereotyped. Moscow, Litterra, 2010, 880 p. (In Rus.)
8. Sarles H, Sarles J-C, Muratore R, Guien C. Chronic inflammatory sclerosis of the pancreas – An autonomous pancreatic disease? Am J Dig Dis. 1961; 6 (7): 688–698
9. Raffaele Pezzilli. Etiology of chronic pancreatitis: Has it changed in the last decade? World J Gastroenterol. 2009; 15(38): 4737–4740.
10. Kim HJ, Byun JH, Park SH, et al. Focal fatty replacement of the pancreas: usefulness of chemical shift MRI. AJR Am J Roentgenol. 2007;188:429–32. doi: 10.2214/AJR.05.1095.
11. Pezzilli R, Calculli L. Pancreatic steatosis: is it related to either obesity or diabetes mellitus? World J Diabetes. 2014;5:415–9. doi: 10.4239/wjd.v5.i4.415.
12. Morrissey S, Tan KT, Byrne JS. Takayasu arteritis with middle aortic syndrome and mesenteric ischemia treated by aortic stenting. J Vasc Surg Cases Innov Tech. 2017 23;3(3):168–170. doi: 10.1016/j.jvscit.2017.06.004.
13. Jung Yoon Pyo, Jin Su Park, Chang Ho Song, Sang Won Lee, Yong Beom Park, and Soo Kon Lee. Takayasu arteritis associated with ulcerative colitis and optic neuritis: first case in Korea. Korean J Intern Med. 2013 Jul; 28(4): 491–496.
14. You-shi Liu, You-hong Fang, Ling-xiang Ruan, You-ming Li, Lin Li, Ling-ling Jiang. Takayasu’s arteritis associated with Crohn’s disease. J Zhejiang Univ Sci B. 2009 Aug; 10(8): 631–634.
15. Isohisa I, Ishiai S, Oda H, Sasagawa Y, Numano F, Maezawa H. A case of Takayasu disease with autoimmune hepatitis. Nihon Naika Gakkai Zasshi. 1985;74(7):939–44.
16. Alokaily F1, Bzeizi K, Al-Nori R, Alqahtani S. Takayasu’s arteritis and liver transplantation: Association and implications. Saudi J Gastroenterol. 2015;21(5):337–40. doi: 10.4103/1319-3767.166201.
Review
For citations:
Borodina I.E., Spirin A.B., Popov A.A., Osadchaya N.A., Kozulin A.A. Retrospective analysis of gastrointestinal pathology associated with Takayasu arteritis. Experimental and Clinical Gastroenterology. 2020;(6):101-105. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-178-6-101-105
Views:
466
Email this article 