The effectiveness and safety of a polypeptide drug (Laennec) for the treatment of COVID-19
https://doi.org/10.31146/1682-8658-ecg-178-6-55-63
Abstract
Hyperferritinemia in patients with COVID-19 is associated with liver dysfunction and an increased risk of the “cytokine storm”. The polypeptide preparation Laennec (6 ml per 350 ml of 0.9% NaCl solution, iv, cap. The first 3 days, from 4 days — 6 ml per 250 ml of 0.9% NaCl solution) was used in 14 patients (age 39–86 years old, 6 men, 8 women) with a long, stagnant course of COVID-19 as a hepatoprotector and immunomodulator as part of complex therapy until a stable remission is achieved. Patients in the control group (n = 14) received only standard therapy. The use of Laennec led to positive clinical dynamics: a decrease in ferritin levels (in men by –282 mcg / l, in women by –80 mcg / l, P = 0.039), an increase in blood oxygenation to the normal range (P = 0.0029), and a decrease in the area of damage lung according to CT data (on average, —10%, P = 0.0027), an increase in the relative content of lymphocytes (+ 8%, P = 0.04), normalization of markers of liver dysfunction (AST, ALT), creatinine and systolic blood pressure (P <0.05). All patients treated with Laennec recovered within 3–15 days after the start of the drug and were discharged with a negative test for the SARS-CoV-2 virus.
About the Authors
V. A. Maksimov
FGBOU DPO RMAPO Ministry of Health of Russia
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor, Department of Dietetics and Nutritionology,
Moscow
I. Yu. Torshin
FIC IU RAS;
Center for Big Data Storage and Analysis, Moscow State University
Russian Federation
Russian Federation
candidate of physical and mathematical sciences, candidate of chemical sciences, senior researcher Institute of Pharmacoinformatics,
Moscow
A. G. Chuchalin
FGAOU IN RNIMU them. N. I. Pirogova of the Ministry of Health of Russia
Russian Federation
Russian Federation
Academician of the Russian Academy of Sciences, Head of the Department of Hospital Therapy, Pediatric Faculty, pulmonologist,
Moscow
O. N. Tkacheva
Russian Gerontological Scientific and Clinical Center at the Federal State Autonomous Educational Institution of Higher Education N. I. Pirogov
Russian Federation
Russian Federation
MD, professor, director of Clinical Center; chief freelance geriatrician of the Ministry of Health of Russia,
Moscow
I. D. Strazhesko
Russian Gerontological Scientific and Clinical Center at the Federal State Autonomous Educational Institution of Higher Education N. I. Pirogov
Russian Federation
Russian Federation
Deputy Director for Translational Medicine, Head of the Laboratory for Translational Research in Gerontology, Candidate of Medical Sciences, Cardiologist,
Moscow
O. A. Gromova
FIC IU RAS;
Center for Big Data Storage and Analysis, Moscow State University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor, Senior Researcher, Scientific Director of the Institute of Pharmacoinformatics; Leading researcher at the Center for Big Data Storage and Analysis,
Moscow
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For citations:
Maksimov V.A., Torshin I.Yu., Chuchalin A.G., Tkacheva O.N., Strazhesko I.D., Gromova O.A. The effectiveness and safety of a polypeptide drug (Laennec) for the treatment of COVID-19. Experimental and Clinical Gastroenterology. 2020;(6):55-63. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-178-6-55-63
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