Autopsy incidence rate of fatty liver disease in the Irkutsk region
https://doi.org/10.31146/1682-8658-ecg-176-4-72-76
Abstract
The aim. To study the epidemiology of fatty liver disease among the population of the Irkutsk region.
Materials and methods. The study was conducted on the basis of “Irkutsk Regional Bureau of Forensic Medical Examination». The object of the study was medical documentation — “The act of autopsy”.
Results. The analysis of the results of 7809 autopsies performed in 2012. A total of 7246 acts of autopsy were examined. Morphological signs of fatty liver disease were detected in 1602 (22.1%) cases.
Conclusion. 1. Fatty liver disease among residents of the Irkutsk region is 22.1%, and does not depend on gender: for women, 21.8% and for men, 22.3%;
2. Fatty liver disease is signifi cantly more common in women in the age group from 25 to 59 years, in other age groups there is no diff erence between men and women. People of young, old age and long-livers are least susceptible to fatty liver disease;
3. The median life expectancy of those who died of cardiovascular diseases with steatohepatitis is 2.5 years less than with steatosis, while the DALY index with steatosis is 13.6 years, and with steatohepatitis is 13.5 years, which has no significant diff erence.
About the Authors
O. V. Tirikova
Irkutsk State Medical University
Russian Federation
MD, assistant lecturer of the Department of Faculty Therapy
664003, Irkutsk, street Krasnogo Vosstaniya, 1
Russian Federation
MD, assistant lecturer of the Department of Faculty Therapy
664003, Irkutsk, street Krasnogo Vosstaniya, 1
N. M. Kozlova
Irkutsk State Medical University
Russian Federation
MD, PhD, head of the Department of Faculty Therapy
664003, Irkutsk, street Krasnogo Vosstaniya, 1
Russian Federation
MD, PhD, head of the Department of Faculty Therapy
664003, Irkutsk, street Krasnogo Vosstaniya, 1
A. U. Tarasov
Irkutsk State Medical University
Russian Federation
MD, deputy chief doctor
664003, Irkutsk, street Krasnogo Vosstaniya, 1
Russian Federation
MD, deputy chief doctor
664003, Irkutsk, street Krasnogo Vosstaniya, 1
S. M. Eliseev
Irkutsk State Medical University
Russian Federation
MD, associate Professor
664003, Irkutsk, street Krasnogo Vosstaniya, 1
Russian Federation
MD, associate Professor
664003, Irkutsk, street Krasnogo Vosstaniya, 1
S. V. Lunenok
Irkutsk Regional Bureau of Forensic Medical Examination
Russian Federation
MD, head of forensic histology department
664022, Irkutsk, street Gagarina, 4
Russian Federation
MD, head of forensic histology department
664022, Irkutsk, street Gagarina, 4
References
1. Lazebnik L. B., Radchenko V. G., Golovanova E. V. et al. Non-alcoholic fatty liver disease: clinical presentation, diagnosis, treatment (recommendations for therapists, 2nd version). Experimental and Clinical Gastroenterology. 2017;138(02):22–37.
2. Ivashkin V. T., Ivashkina N. Yu., Baranskaya E. K. et al. Alcoholic liver disease. Rational pharmacotherapy of diseases of the digestive system. A Guide for Medical Practitioners 2nd Edition. M. “Litterra”, 2011, 844 p.
3. Kleiner DE, Brunt EM, Van Natta M et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology, 2005, vol. 41, pp. 1313–1321.
4. Bellentani S., Marino M. Epidemiology and natural history of non-alcoholic fatty liver disease (NAFLD). Annals of Hepatology. 2009, vol. 8, no. 1, pp. 4–8.
5. Vernon G., Baranova A., Younossi Z. M. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Alimentary Pharmacology and Therapeutics. 2011, vol. 34, no. 3, pp. 274–285.
6. McCullough AJ. The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin Liver Dis. 2004, no. 8, pp. 521–533.
7. Drapkina OM, Smirin V. I., Ivashkin V. T. Pathogenesis, treatment, epidemiology NAFLD – what’s new? Epidemiology of NAFLD in Russia. Russian Medical Journal. 2011, No. 28, pp. 1717–1721.
8. Ivashkin V. T., Drapkina OM, Maev I. V. The prevalence of non-alcoholic fatty liver disease in patients with outpatient practice in the Russian Federation: the results of the DIREG 2 study. Hepatology. 2015, № 6, pp. 31–41.
Review
For citations:
Tirikova O.V., Kozlova N.M., Tarasov A.U., Eliseev S.M., Lunenok S.V. Autopsy incidence rate of fatty liver disease in the Irkutsk region. Experimental and Clinical Gastroenterology. 2020;174(4):72-76. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-176-4-72-76
Views:
324
Email this article 