Choleretic activity of dry extracts of Carthamus tinctorius L., Tagetes erecta L.Calendula officinalis L.
https://doi.org/10.31146/1682-8658-ecg-175-3-76-79
Abstract
The aim of the present work was to estimate the choleretic effect of dry extracts derived from Carthamus tinctotius L., Calendula officinalis L. and Tagetes erecta L.
Materials and methods: The experiments were carried out on white male rats weighing 180–230 g. The extracts in a single dose were introduced into the duodenum of the rats at the doses of 50, 100 and 200 mg/kg in the form of water solution.
Results: The results of the experiments have shown that the extracts from Calendula officinalis and Carthamus tinctorius have the marked choleretic effect due to the presence of biologically active substances, predominantly fl avonoids.
About the Authors
S. M. Nikolaev
State Federal Budgetary Scientific Organization Institute of General and Experimental Biology Siberian Branch Russian Academy of Science
Russian Federation
Russian Federation
Sergei M. Nikolaev, The Head of Laboratory of Experimental Pharmacology, Doctor of Sciences (Medicine), professor
Scopus Author ID: 7005282338
670047, Sakh’yanovoy Str., 6, Ulan-Ude
N. S. Badmaev
State Federal Budgetary Scientific Organization Institute of General and Experimental Biology Siberian Branch Russian Academy of Science
Russian Federation
Russian Federation
Nikita S. Badmaev, Laboratory of Experimental Pharmacology, post-graduate student
Scopus Author ID: 57200203839
670047, Sakh’yanovoy Str., 6, Ulan-Ude
Z. G. Sambueva
State Federal Budgetary Scientific Organization Institute of General and Experimental Biology Siberian Branch Russian Academy of Science
Russian Federation
Russian Federation
Zinaida G. Sambueva, Laboratory of Experimental Pharmacology, Candidate of Sciences (Biology), senior researcher
Scopus Author ID: 6602533961
670047, Sakh’yanovoy Str., 6, Ulan-Ude
D. N. Olennikov
State Federal Budgetary Scientific Organization Institute of General and Experimental Biology Siberian Branch Russian Academy of Science
Russian Federation
Russian Federation
Daniil N. Olennikov, Laboratory of Medical and Biological Research, Doctor of Sciences (Pharmacy), leading researcher
Scopus Author ID: 6506525133
670047, Sakh’yanovoy Str., 6, Ulan-Ude
N. I. Kashchenko
State Federal Budgetary Scientific Organization Institute of General and Experimental Biology Siberian Branch Russian Academy of Science
Russian Federation
Russian Federation
Nina I. Kashchenko, Laboratory of Medical and Biological Research, Candidate of Sciences (Pharmacy), researcher
Scopus Author ID: 55930999500
670047, Sakh’yanovoy Str., 6, Ulan-Ude
References
1. Nikolaev S. M. Rastitel’nye preparaty pri povrezhdeniyakh gepatobiliarnoy sistemy [Herbal remedies for injuries of the hepatobiliary system]. Novosibirsk, 1992, 155 p.
2. Nikolaev S. M. Fitofarmakoterapiya I fitifarmakoprofilaktika zabolevanii [Phytopharmacoterapy and phytopharmacoprophylaxis of diseases]. Ulan-Ude, 2012, 286 p.
3. Pradhan S.C., Girich С. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian Journal of Medical Research. – 2006. – Vol. 124. – P. 491–504.
4. Okovityi S. V., Bezborodkina N. N., Uleichik S. G., Shulenin S. N. Gepatoprotektory [Hepatoprotectors]. Moscow, 2010, 112 p.
5. Korsun E. V. Fititerapiya khonicheskogo virusnogo gepatita [Phytoterapy of chronic viral hepatitis]. Vrach – Doctor. 2006, no. 14, pp. 48–51.
6. Lesiovskaya E. E., Khossel’khort О., Frolova N. Yu. Fititerapia v reabilitatcii bol’nykh perenesshykh gepatit virusnoy etiologii [Phytoterapy in rehabilitation of patients aft er hepatitis of viral etiology]. AguaVitae. 2000, no. 3, pp. 34–37.
7. Sur S. V. Problemy I perspektivy razrabotki I vnedreniya sovremennykh lekarstvennykh sredstv rastitel’nogo proishozhdeniya [Problems and prospects for the development and implementation of modern herbal medicines]. Farmateka. 2001, no. 9–10. pp. 10–14.
8. Miroshnichenko V. P., Gromashevskaya L. L., Kasatkina M. G. et al. Opredelenie soderzhaniya zhelchnykh kislot I holesterina v zhelchi [Determination of bile acids and cholesterol in bile]. Laboratornoye Delo – Laboratory Practice. 1978, no. 3, pp. 149–153.
9. Skakun N. P., Oleinik A. N. Sravnitel’noye deistvie atropine I metacina na vneshnesekretornuyu funkciu pecheni [Comparative eff ect of atropine and metacin on exocrine liver function]. Farmakologia i Toksikologiya – Pharmacology and Toxicology. 1967, vol. 30, no. 3, pp. 334–337.
10. Olennikov D.N., Kashchenko N. I., Chirikova N. K., Tankhaeva L. M. Iridoids and flavonoids of four Siberian gentians: Chemical profi le and gastric stimulatory effect. Molecules. – 2015. – Vol. 20. – P. 19172–19188.
11. Olennikov D.N., Kashchenko N. I. New isorhamnetin glucosides and other phenolic compounds from Calendula officinalis. Chem. Nat. Comp. – 2013. – Vol. 49. P. 833–840.
12. Olennikov D.N., Kashchenko N. I. Componential profile and amylase inhibiting activity of phenolic compounds from Calendula officinalis L. leaves. Scientific World Journal. – 2014. – Vol. 2014. – Art. ID. 654193.
13. Olennikov D.N., Kashchenko N. I., Chirikova N. K., et al. Isorhamnetin and quercetin derivatives as anti-acetylcholinesterase principles of marigold (Calendula offi cinalis) flowers and preparations. Int. J. Molec. Sci. – 2017. – Vol. 18. – Art. No 1685.
14. Olennikov D.N., Kashchenko N. I., Vennos C. A new esculetin glycoside from Calendula offi cinalis (Asteraceae) and its bioactivity. Farmacia. – 2017. – Vol. 65. – P. 698– 702
15. Wagner H. Chromatographic fingerprint analysis of herbal medicines. Flos Carthami. Wien: Springer-Verlag, 2011. – P. 475–483.
16. Xu L., Chen J., Qi H., Shi Y. Phytochemicals and their biological activities of plants in Tagetes L.. Chin. Herb. Med. – 2012. – Vol. 4. – P. 103–117.
17. Miyake Y., Yamamoto K., Morimitsu Y., Osawa T. Isolation of C-glucosylfl avone from lemon peel and antioxidative activity of flavonoid compounds in lemon fruit. J. Agric. Food Chem. – 1997. – Vol. 45. – P. 4619–4623.
Review
For citations:
Nikolaev S.M., Badmaev N.S., Sambueva Z.G., Olennikov D.N., Kashchenko N.I. Choleretic activity of dry extracts of Carthamus tinctorius L., Tagetes erecta L.Calendula officinalis L.. Experimental and Clinical Gastroenterology. 2020;(3):76-79. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-175-3-76-79
Views:
496
Email this article 