Morphofunctional estimation of the gastroprotective activity of the Ferulopsis hystrix dry extract in neurogenic ulcer
https://doi.org/10.31146/1682-8658-ecg-175-3-71-75
Abstract
The purpose of the research: morphofunctional estimation of the gastroprotective activity of the dry extract from the roots and rhizomes of Ferulopsis hystrix in neurogenic ulcer.
Materials and methods: The studies were carried out on white Wistar rats. The neurogenic ulcer was simulated by 24-hour immobilization of the animals. The gastroprotective effect of Ferulopsis hystrix was estimated taking into account the Pauls’ index which was calculated for bleedings, erosions and strip-like ulcers as well as taking into account the morphometric indices (the depth of erosions) of the stomach mucosa. The intensity of lipid free radical oxidation processes was estimated by malonic dialdehyde content (MDA); the state of the antioxidant system was estimated by the activity of catalase, superoxide dismutase and the reduced glutathione content.
Results. The Ferulopsis hystrix extract in the doses of 100 and 150 mg/kg reduces the depth of erosions by 43% and 80% respectively, thus promoting the diminishment of destructive processes in the stomach mucosa against the background of neurogenic ulcer. The Ferulopsis hystrix extract in the given doses decreased the MDA content by 37% on average; the catalase activity was twofold increased; the reduced glutathione increases 2.6 times and SOD activity — 3.8 and 2.8 times respectively.
Conclusion. Ferulopsis hystrix has the gastroprotective effect in neurogenic ulcer.
About the Authors
S. M. Salchak
Institute of General and Experimental Biology; Scientific research Institute of medical-social problems and management of the Republic of Tuva
Russian Federation
Russian Federation
Sayzana M. Salchak, Laboratory of safety of biological active substances, Post-graduate Student
eLibrary SPIN: 8464–0818
Ulan-Ude; Kyzyl
Ya. G. Razuvaeva
Institute of General and Experimental Biology
Russian Federation
Russian Federation
Yanina G. Razuvaeva, Laboratory of safety of biological active substances, Senior Research Office, Doctor of Biological Sciences
eLibrary SPIN: 8338–9336
Ulan-Ude
A. A. Toropova
Institute of General and Experimental Biology
Russian Federation
Russian Federation
Anyuta A. Toropova, Laboratory of safety of biological active substances, Research Officer, Candidate of Biological Sciences
eLibrary SPIN: 4457–1872
Ulan-Ude
K. D. Arakchaa
Scientific research Institute of medical-social problems and management of the Republic of Tuva
Russian Federation
Russian Federation
Kara-kys D. Arakchaa, Director, Candidate of Chemical Sciences
eLibrary SPIN: 7712–7510
Kyzyl
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Review
For citations:
Salchak S.M., Razuvaeva Ya.G., Toropova A.A., Arakchaa K.D. Morphofunctional estimation of the gastroprotective activity of the Ferulopsis hystrix dry extract in neurogenic ulcer. Experimental and Clinical Gastroenterology. 2020;(3):71-75. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-175-3-71-75
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