TNF-Α polymorphic G-308A variant correlation with the severity of the course of the inflammatory bowel disease in tomsk region

Abstract

The aim of the research is to study the influence of concentration of the tumor necrosis factor alpha (TNF-α) in the blood serum and polymorphic genes variants TNF-α (G-308A) on the clinical course of Crohn’s disease and Ulcerative colitis. Materials and methods. We examined 123 patients with inflammatory bowel diseases, observational group consisted of 40 healthy volunteers. Results. Findings of a study have shown that serum TNF-alpha level is increased greatly among the inflammatory bowel disease patients in comparison with the value of the observational group and correlates with the disease activity. Crohn’s disease patients had TNF-α polymorphic G-308A variant 6 times oftener than ones in the observational group. Patients with TNF-α -308A allele had a more severe disease, however no veridical relations between TNF-α polymorphic G-308A variant and the course of the Crohn’s disease were discovered.