Microparticles of lymphocytic origin - a pathogenetic marker of necrotizing pancreatitis

Purpose: research objective was to establish interrelation between the nature of damage of a pancreas and retroperitoneal space and number of the microparticles which are formed as a result of activation and a blebbing of lymphocytes. Materials and methods. Results of the prospective cohort research which was taking place on clinical bases of department of the general surgery of the prof. M. I. Gulmana KRASGMU in 2013-2017 are presented. Group of clinical observation - 248 patients with the severe acute pancreatitis. For comparison two more groups - group of patients with not severe acute pancreatitis where 35 patients with acute pancreatitis easy and moderate severity and control group of almost healthy faces - 35 people entered were created. For visualization of necrotizing process in a pancreas and retroperitoneal space carried out on the third week of a disease (14-21 days). Blood sampling for assessment of number of lymphocytes and quantity of the circulating microparticles was performed at receipt prior to therapy. Results. The obtained data demonstrate that the microparticles of lymphocytic origin which are formed as a result of activation and a blebbing of lymphocytes can act as an early pathogenetic marker of necrotizing pancreatitis, due to high and very high correlations with a volume (rS=0,84, p <0,001) and depth (rS=0,98 p=0,007) defeats of a parenchyma of a pancreas, and prevalence of pathological process in retroperitoneal space (rS=0,82 p <0,001). Conclusion. The obtained data demonstrate that the microparticles of lymphocytic origin which are formed as a result of activation and a blebbing of lymphocytes can act as an early pathogenetic marker of necrotizing pancreatitis, due to high and very high correlations with a volume and depth of defeat of a parenchyma of a pancreas, and abundance of pathological process in retroperitoneal space.

некротизирующий панкреатит, микрочастицы, лимфоциты, блеббинг, necrotizing pancreatitis, microparticle, lymphocytes, blebbing