Features of the pancreatic histostructure in chronic pancreatitis

Abstract

Aim - to study the morphological features of the pancreas in clinical and morphological forms of chronic pancreatitis. Materials and methods. Histological preparations of the pancreas were studied in 60 patients with various forms of chronic pancreatitis. Results. Scant inflammatory infiltration of the pancreatic parenchyma (represented by lymphocytes, plasma cells), atrophic and fibrotic changes, which were characterized by unidirection, were detected. The fibrosis was of two kinds - friable and dense fibrosis, that qualitative state of the connecting tissue at the different forms of chronic pancreatitis. Friable fibrosis has been revealed at patients for mild and moderate chronic pancreatitis and dense - for severe and complete fibrosis. Conclusion The morphological picture of fibrous changes of the pancreas does not depend on the form of the disease and is characterized by a mild degree of fibrosis in 6.6% of patients, moderate - in 20.0%, severe - 16.7%, full fibrosis - 56.7%.