Acute viral gastroenteritis in pregnant women

Objective: to determine the epidemiological, clinical and laboratory features of viral acute gastroenteritis (AGE) in hospitalized pregnant women and to evaluate of the effectiveness of synbiotics in the treatment of AGE in pregnant women. Materials and methods: The study involved 482 adult patients with AGE hospitalized from February to June 2017, including 103 pregnant women aged from 21 to 37 years. Along with the generally accepted diagnostic methods, feces were studied by PCR using a set of original specific primers to detect rotaviruses of group A and group C, noroviruses of the second gene group (HNoV GII) and astroviruses. Identified virus isolates were genotyped. Results: out of 103 pregnant women with AGE, more than half of cases (53.3%) accounted for viral AGE: norovirus - 51.4% of cases, rotavirus - 1.9%. Astrovirus infection was not registered. Noroviruses of new genotypes GII.P17 / GII.17 and GII.P16 / GII.2, and rotavirus genotype G9P were detected in pregnant women with AGE. In noroviral AGE, the food route of transmission prevailed, the leading factors of transmission were salads and dairy products. The disease proceeded in moderate form and had clinical features characteristic of norovirus infection. In pregnant women with AGE of norovirus etiology and unspecified etiology, using of synbiotic “Normobact” in the combined therapy, the earlier arrest of diarrhea was noted comparing with patients receiving only pathogenetic therapy (p <0.05). Conclusion: the established high frequency of viral AGE in pregnant women shows the need for introducing into clinical practice universal test systems for diagnosing the most common viral pathogens in order to improve therapy. The effectiveness of synbiotic “Normobact” in pregnant women with viral OGE was shown in terms of earlier stopping diarrhea, which makes it possible to recommend it as part of complex therapy.

острый вирусный гастроэнтерит, норовирусы, ротавирусы, астровирусы, эпидемиология, клинические и лабораторные проявления, полимеразная цепная реакция, беременные, синбиотик, acute viral gastroenteritis, noroviruses, rotaviruses, astroviruses, epidemiology, clinical and laboratory manifestations, polymerase chain reaction, pregnant women, synbiotic